A cellular census of human lungs identifies novel cell states in health and in asthma
Vieira Braga, Felipe A, Kar, Gozde, Berg, Marijn, Carpaij, Orestes A, Polanski, Krzysztof, Simon, Lukas M, Brouwer, Sharon, Gomes, Tomás, Hesse, Laura, Jiang, Jian, Fasouli, Eirini S, Efremova, Mirjana, Vento-Tormo, Roser, Talavera-López, Carlos, Jonker, Marnix R, Affleck, Karen, Palit, Subarna, Strzelecka, Paulina M, Firth, Helen V, Mahbubani, Krishnaa T, Cvejic, Ana, Meyer, Kerstin B, Saeb-Parsy, Kourosh, Luinge, Marjan, Brandsma, Corry-Anke, Timens, Wim, Angelidis, Ilias, Strunz, Maximilian, Koppelman, Gerard H, van Oosterhout, Antoon J, Schiller, Herbert B, Theis, Fabian J, van den Berge, Maarten, Nawijn, Martijn C, Teichmann, Sarah A
Published in Nature medicine (01.07.2019)
Published in Nature medicine (01.07.2019)
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Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33
Saikumar Jayalatha, Akshaya Keerthi, Jonker, Marnix R, Carpaij, Orestes A, van den Berge, Maarten, Affleck, Karen X, Koppelman, Gerard H, Nawijn, Martijn C
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2024)
Published in American journal of physiology. Lung cellular and molecular physiology (01.01.2024)
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P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation
Salcman, Barbora, Affleck, Karen, Bulfone-Paus, Silvia
Published in Cells (Basel, Switzerland) (02.09.2021)
Published in Cells (Basel, Switzerland) (02.09.2021)
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The Effects of the Novel, Reversible Epidermal Growth Factor Receptor/ErbB-2 Tyrosine Kinase Inhibitor, GW2016, on the Growth of Human Normal and Tumor-derived Cell Lines in Vitro and in Vivo
Rusnak, D W, Lackey, K, Affleck, K, Wood, E R, Alligood, K J, Rhodes, N, Keith, B R, Murray, D M, Knight, W B, Mullin, R J, Gilmer, T M
Published in Molecular cancer therapeutics (01.12.2001)
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Published in Molecular cancer therapeutics (01.12.2001)
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Regulatory T-cell–intrinsic amphiregulin is dispensable for suppressive function
Carney, Katharine, PhD, Chang, Yu-Mei (Ruby), CStat, PhD, Wilson, Stephen, BSc, Calnan, Clare, PhD, Reddy, Pala S., MSc, Chan, Win-Yan, MSc, Gilmartin, Timothy, SB, Hernandez, Gilberto, MS, Schaffer, Lana, MS, Head, Steven R., MS, Morley, Joanne, BSc, de Mestre, Amanda, PhD, MRCVS, Affleck, Karen, PhD, Garden, Oliver A., PhD, MRCVS
Published in Journal of allergy and clinical immunology (01.06.2016)
Published in Journal of allergy and clinical immunology (01.06.2016)
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Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents
Hamann, Martine, Gibson, Adele, Davies, Noel, Jowett, Amanda, Walhin, Jean Philippe, Partington, Leanne, Affleck, Karen, Trezise, Derek, Main, Martin
Published in The Journal of physiology (15.05.2009)
Published in The Journal of physiology (15.05.2009)
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Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue
Patou, Joke, Holtappels, Gabriele, Affleck, Karen, Gevaert, Philippe, Perez-Novo, Claudina, Van Cauwenberge, Paul, Bachert, Claus
Published in Journal of inflammation (London, England) (20.04.2009)
Published in Journal of inflammation (London, England) (20.04.2009)
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Identification of asthma-associated microRNAs in bronchial biopsies
Roffel, Mirjam P, Boudewijn, Ilse M, van Nijnatten, Jos L L, Faiz, Alen, Vermeulen, Corneel J, van Oosterhout, Antoon J, Affleck, Karen, Timens, Wim, Bracke, Ken R, Maes, Tania, Heijink, Irene H, Brandsma, Corry-Anke, van den Berge, Maarten
Published in The European respiratory journal (01.03.2022)
Published in The European respiratory journal (01.03.2022)
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Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission
Vermeulen, Cornelis J, Xu, Cheng-Jian, Vonk, Judith M, Ten Hacken, Nick H T, Timens, Wim, Heijink, Irene H, Nawijn, Martijn C, Boekhoudt, Jeunard, van Oosterhout, Antoon J, Affleck, Karen, Weckmann, Markus, Koppelman, Gerard H, van den Berge, Maarten
Published in The European respiratory journal (01.02.2020)
Published in The European respiratory journal (01.02.2020)
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Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma Exacerbations In Vivo : A Clinical Trial
Dhariwal, Jaideep, Cameron, Aoife, Wong, Ernie, Paulsen, Malte, Trujillo-Torralbo, Maria-Belen, Del Rosario, Ajerico, Bakhsoliani, Eteri, Kebadze, Tatiana, Almond, Mark, Farne, Hugo, Gogsadze, Leila, Aniscenko, Julia, Rana, Batika M J, Hansel, Trevor T, Jackson, David J, Kon, Onn Min, Edwards, Michael R, Solari, Roberto, Cousins, David J, Walton, Ross P, Johnston, Sebastian L
Published in American journal of respiratory and critical care medicine (01.12.2021)
Published in American journal of respiratory and critical care medicine (01.12.2021)
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IL1RAP expression and the enrichment of IL‐33 activation signatures in severe neutrophilic asthma
Badi, Yusef Eamon, Salcman, Barbora, Taylor, Adam, Rana, Batika, Kermani, Nazanin Zounemat, Riley, John H., Worsley, Sally, Mumby, Sharon, Dahlen, Sven‐Eric, Cousins, David, Bulfone‐Paus, Silvia, Affleck, Karen, Chung, Kian Fan, Bates, Stewart, Adcock, Ian M.
Published in Allergy (Copenhagen) (01.01.2023)
Published in Allergy (Copenhagen) (01.01.2023)
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Targeting phosphoinositide 3-kinase δ for allergic asthma
Rowan, Wendy C, Smith, Janet L, Affleck, Karen, Amour, Augustin
Published in Biochemical Society transactions (01.02.2012)
Published in Biochemical Society transactions (01.02.2012)
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Isolation and Characterisation of a Prenylated p-Terphenyl Metabolite of Aspergillus candidus Possessing Potent and Selective Cytotoxic Activity; Studies on Mechanism of Action
AFFLECK, KAREN, SIDEBOTTOMC, PHILIP J., SIDEBOTTOM, PHILIP J., TAYLOR, NICHOLAS L., DRAKE, CHRISTOPHER S., TODD, MARTIN, JOWETT, AMANDA, WEBB, GRAHAM
Published in Journal of antibiotics (01.02.1999)
Published in Journal of antibiotics (01.02.1999)
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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors
Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Orai and TRPC channel characterization in FcεRI‐mediated calcium signaling and mediator secretion in human mast cells
Wajdner, Hannah E., Farrington, Jasmine, Barnard, Claire, Peachell, Peter T., Schnackenberg, Christine G., Marino, Joseph P., Xu, Xiaoping, Affleck, Karen, Begg, Malcolm, Seward, Elizabeth P.
Published in Physiological reports (01.03.2017)
Published in Physiological reports (01.03.2017)
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Topological data analysis (TDA) of U-BIOPRED paediatric peripheral blood gene expression identified asthma phenotypes characterised by alternative splicing of glucocorticoid receptor (GR) mRNA
Schofield, James P. R., Bigler, Jeanette, Boedigheimer, Michael, Affleck, Karen, Taylor, Adam, Pavlidis, Stelios, Riley, John H., Strazzeri, Fabio, Roberts, Graham, Brandsma, Joost, Bansal, Aruna, Nicholas, Ben, Xian, Yang, Rowe, Anthony, Corfield, Julie, Wilson, Susan, Ward, Jonathan, Lutter, Rene, Fleming, Louise, Shaw, Dominick, Per, Bakke, Caruso, Massimo, Dahlen, Sven-Erik, Fowler, Stephen, Hashimoto, Simone, Horvath, Ildiko, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Singer, Florian, Sun, Kai, Pandis, Ioannis, Auffray, Charles, de Meulder, Bertrand, Lefaudeux, Diane, Knowles, Richard, Fitch, Neil, Sousa, Ana, Adcock, Ian, Chung, Kian Fan, Sterk, Peter, Skipp, Paul, Djukanovic, Ratko
Published in EUROPEAN RESPIRATORY JOURNAL (2018)
Published in EUROPEAN RESPIRATORY JOURNAL (2018)
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Syk-kinase inhibition prevents mast cell activation in nasal polyps
Patou, Joke, Holtappels, Gabriele, Affleck, Karen, van Cauwenberge, Paul, Bachert, Claus
Published in Rhinology (01.03.2011)
Published in Rhinology (01.03.2011)
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Journal Article
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J
Published in Cancer research (Chicago, Ill.) (01.10.2001)
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Published in Cancer research (Chicago, Ill.) (01.10.2001)
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