Search Results - "Aebi, D." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

by Liu, Yongfu, Wu, Jun, Zhou, Mingwei, Chen, Wenming, Li, Dongbo, Wang, Zhanguo, Hornsperger, Benoit, Aebi, Johannes D, Märki, Hans-Peter, Kuhn, Bernd, Wang, Lisha, Kuglstatter, Andreas, Benz, Jörg, Müller, Stephan, Hochstrasser, Remo, Ottaviani, Giorgio, Xin, Jian, Kirchner, Stephan, Mohr, Susanne, Verry, Philippe, Riboulet, William, Shen, Hong C, Mayweg, Alexander V, Amrein, Kurt, Tan, Xuefei
Published in Journal of medicinal chemistry (09.07.2020)

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Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

by Martin, Rainer E, Aebi, Johannes D, Hornsperger, Benoit, Krebs, Hans-Jakob, Kuhn, Bernd, Kuglstatter, Andreas, Alker, André M, Märki, Hans Peter, Müller, Stephan, Burger, Dominique, Ottaviani, Giorgio, Riboulet, William, Verry, Philippe, Tan, Xuefei, Amrein, Kurt, Mayweg, Alexander V
Published in Journal of medicinal chemistry (22.10.2015)

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Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury

Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury

by Wyss, Jean-Christophe, Kumar, Rajesh, Mikulic, Josip, Schneider, Manfred, Mary, Jean-Luc, Aebi, Johannes D., Juillerat-Jeanneret, Lucienne, Golshayan, Dela
Published in Frontiers in pharmacology (08.11.2019)

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

by Martin, Rainer E., Lehmann, Johannes, Alzieu, Thibaut, Lenz, Mario, Corrales, Marjorie A. Carnero, Aebi, Johannes D., Marki, Hans Peter, Kuhn, Bernd, Amrein, Kurt, Mayweg, Alexander V., Britton, Robert
Published in Organic & biomolecular chemistry (01.01.2016)

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Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

by Dehmlow, Henrietta, Aebi, Johannes D, Jolidon, Synèse, Ji, Yu-Hua, von der Mark, Elisabeth M, Himber, Jacques, Morand, Olivier H
Published in Journal of medicinal chemistry (17.07.2003)

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Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

by Berger, Yann, Dehmlow, Henrietta, Blum-Kaelin, Denise, Kitas, Eric A, Löffler, Bernd-Michael, Aebi, Johannes D, Juillerat-Jeanneret, Lucienne
Published in Journal of medicinal chemistry (27.01.2005)

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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

by Morand, O H, Aebi, J D, Dehmlow, H, Ji, Y H, Gains, N, Lengsfeld, H, Himber, J
Published in Journal of lipid research (01.02.1997)

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Targeted γ-secretase inhibition of Notch signaling activation in acute renal injury

Targeted γ-secretase inhibition of Notch signaling activation in acute renal injury

by Wyss, Jean-Christophe, Kumar, Rajesh, Mikulic, Josip, Schneider, Manfred, Aebi, Johannes D, Juillerat-Jeanneret, Lucienne, Golshayan, Dela
Published in American journal of physiology. Renal physiology (01.05.2018)

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A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold

A New Class of Inhibitors for the Metalloprotease Neprilysin Based on a Central Imidazole Scaffold

by Sahli, Stefan, Stump, Bernhard, Welti, Tobias, Schweizer, W. Bernd, Diederich, François, Blum-Kaelin, Denise, Aebi, Johannes D., Böhm, Hans-Joachim
Published in Helvetica chimica acta (01.04.2005)

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A Novel Inhibitor of Oxidosqualene:Lanosterol Cyclase Inhibits Very Low–Density Lipoprotein Apolipoprotein B100 (ApoB100) Production and Enhances Low-Density Lipoprotein ApoB100 Catabolism Through Marked Reduction in Hepatic Cholesterol Content

A Novel Inhibitor of Oxidosqualene:Lanosterol Cyclase Inhibits Very Low–Density Lipoprotein Apolipoprotein B100 (ApoB100) Production and Enhances Low-Density Lipoprotein ApoB100 Catabolism Through Marked Reduction in Hepatic Cholesterol Content

by Telford, Dawn E, Lipson, Sara M, Barrett, P Hugh R, Sutherland, Brian G, Edwards, Jane Y, Aebi, Johannes D, Dehmlow, Henrietta, Morand, Olivier H, Huff, Murray W
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2005)

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Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-Ray Crystal-Structure Analysis

Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-Ray Crystal-Structure Analysis

by Sahli, Stefan, Frank, Brian, Schweizer, W. Bernd, Diederich, François, Blum-Kaelin, Denise, Aebi, Johannes D., Böhm, Hans-Joachim, Oefner, Christian, Dale, Glenn E.
Published in Helvetica chimica acta (01.04.2005)

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Targeted γ‑Secretase Inhibition To Control the Notch Pathway in Renal Diseases

Targeted γ‑Secretase Inhibition To Control the Notch Pathway in Renal Diseases

by Juillerat-Jeanneret, Lucienne, Flohr, Alexander, Schneider, Manfred, Walter, Isabelle, Wyss, Jean-Christophe, Kumar, Rajesh, Golshayan, Dela, Aebi, Johannes D
Published in Journal of medicinal chemistry (22.10.2015)

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Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071

Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071

by Liang, Yayun, Besch-Williford, Cynthia, Aebi, Johannes D., Mafuvadze, Benford, Cook, Matthew T., Zou, Xiaoqin, Hyder, Salman M.
Published in Breast cancer research and treatment (01.07.2014)

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Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

by Staedler, Davide, Chapuis-Bernasconi, Catherine, Dehmlow, Henrietta, Fischer, Holger, Juillerat-Jeanneret, Lucienne, Aebi, Johannes D
Published in Journal of medicinal chemistry (14.06.2012)

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Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

by Lenhart, Alexander, Reinert, Dirk J, Aebi, Johannes D, Dehmlow, Henrietta, Morand, Oliver H, Schulz, Georg E
Published in Journal of medicinal chemistry (22.05.2003)

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Structure-Based Design, Synthesis, and in vitro Evaluation of Nonpeptidic Neprilysin Inhibitors

Structure-Based Design, Synthesis, and in vitro Evaluation of Nonpeptidic Neprilysin Inhibitors

by Sahli, Stefan, Stump, Bernhard, Welti, Tobias, Blum-Kaelin, Denise, Aebi, Johannes D, Oefner, Christian, Böhm, Hans-Joachim, Diederich, François
Published in Chembiochem : a European journal of chemical biology (05.07.2004)

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A fluorine scan of non-peptidic inhibitors of neprilysin: Fluorophobic and fluorophilic regions in an enzyme active site

A fluorine scan of non-peptidic inhibitors of neprilysin: Fluorophobic and fluorophilic regions in an enzyme active site

by Morgenthaler, Martin, Aebi, Johannes D., Grüninger, Fiona, Mona, Daniel, Wagner, Björn, Kansy, Manfred, Diederich, François
Published in Journal of fluorine chemistry (01.09.2008)

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Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

by Liang, Yayun, Mafuvadze, Benford, Aebi, Johannes D, Hyder, Salman M
Published in OncoTargets and therapy (01.01.2016)

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Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

by Muller, Dominik N, Mullally, Alexander, Dechend, Ralf, Park, Joon-Keun, Fiebeler, Anette, Pilz, Bernhard, Löffler, Bernd-Michael, Blum-Kaelin, Denise, Masur, Stefan, Dehmlow, Henrietta, Aebi, Johannes D, Haller, Hermann, Luft, Friedrich C
Published in Hypertension (Dallas, Tex. 1979) (01.12.2002)

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Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors

Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors

by Kitas, Eric A, Löffler, Bernd-Michael, Daetwyler, Stefan, Dehmlow, Henrietta, Aebi, Johannes D
Published in Bioorganic & medicinal chemistry letters (08.07.2002)

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