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Phase 1 first-in-human clinical trial of AG01, a recombinant monoclonal antibody to progranulin/glycoprotein 88 (PGRN/GP88), to determine the safety, tolerability, pharmacokinetics, and preliminary anti-tumor response in subjects with advanced solid tumor malignancies
Tkaczuk, Katherine H. R., Rosenblatt, Paula, Scilla, Katherine Ann, Mehra, Ranee, Jiang, Yixing, Hausner, Petr Frantisek, Rao, Gautham, Tait, Nancy, Yue, Binbin, Serrero, Ginette
Published in Journal of clinical oncology (01.06.2025)
Published in Journal of clinical oncology (01.06.2025)
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Population Pharmacokinetics of Sotorasib in Healthy Subjects and Advanced Solid Tumor Patients Harboring a KRAS.sup.G12C Mutation from Phase 1 and Phase 2 Studies
Nagase, Mario, Houk, Brett, Vuu, Irene, Cardona, Panli, Dutta, Sandeep, Lin, Chih-Wei
Published in The AAPS journal (01.02.2025)
Published in The AAPS journal (01.02.2025)
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Population Pharmacokinetics of Sotorasib in Healthy Subjects and Advanced Solid Tumor Patients Harboring a KRASG12C Mutation from Phase 1 and Phase 2 Studies
Nagase, Mario, Houk, Brett, Vuu, Irene, Cardona, Panli, Dutta, Sandeep, Lin, Chih-Wei
Published in The AAPS journal (13.01.2025)
Published in The AAPS journal (13.01.2025)
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Population Pharmacokinetics of Sotorasib in Healthy Subjects and Advanced Solid Tumor Patients Harboring a KRAS G12C Mutation from Phase 1 and Phase 2 Studies
Nagase, Mario, Houk, Brett, Vuu, Irene, Cardona, Panli, Dutta, Sandeep, Lin, Chih-Wei
Published in The AAPS journal (13.01.2025)
Published in The AAPS journal (13.01.2025)
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Diagnostic Accuracy of Serum Procalcitonin to Diagnose Sepsis in Advanced Solid Tumor Patients with Fever
Nelwan, Erni Juwita, Yulisar, Reza Nugraha, Adiwinata, Randy, Rinaldi, Ikhwan, Rumende, Cleopas Martin, Sinto, Robert
Published in Acta medica Indonesiana (01.04.2024)
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Published in Acta medica Indonesiana (01.04.2024)
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Development of an LC-MS/MS method for quantitative analysis of Chlorogenic acid in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor
Yang, Fen, Gong, Ji fang, Shen, Lin, Zhang, Chen, Kou, Fu rong, Gao, Jing, Li, Yan, bing Xu, Guo
Published in Journal of pharmaceutical and biomedical analysis (05.01.2020)
Published in Journal of pharmaceutical and biomedical analysis (05.01.2020)
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Phase Ia clinical trial of adoptively transferring peripheral blood-derived cytotoxic T lymphocytes targeting individual neo-antigens to treat patients with advanced solid tumor
Li, Bo, Zhang, Xiaoshi, Liu, Geng, Qiu, Si, Liang, Zhaoduan, Liu, Mingming, Gao, Yan, Xu, Rui-hua
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Abstract CT162: Trial in progress: A phase I, open-label, multicenter study of ZL-1218, an anti-CCR8 IgG1, as a single agent and as combination therapy with anti-PD-1 antibody to evaluate the safety, tolerability, and pharmacokinetics in subjects with advanced solid tumor
Garralda, Elena, Boni, Valentina, Baz, David Vincente, Chaudhry, Arvind, Bazo, Ignacio Gil, Gutierrez, Martin, Malhotra, Jyoti, Alonso, Casal Guzman, Gambardella, Valentina, Chisamore, Michael, Zhou, Renke, Tea, Maria, Doroshow, Deborah
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Population Pharmacokinetics of ABT-806, an Investigational Anti-Epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody, in Advanced Solid Tumor Types Likely to Either Over-Express Wild-Type EGFR or Express Variant III Mutant EGFR
Sharma, Shringi, Mittapalli, Rajendar K., Holen, Kyle D., Xiong, Hao
Published in Clinical pharmacokinetics (01.10.2015)
Published in Clinical pharmacokinetics (01.10.2015)
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Abstract CT193: Phase 1 clinical trial evaluating the safety, tolerability, and immunogenicity of AST-021p, a novel cancer vaccine targeting HSP90-derived epitopes in advanced solid tumor patients (CornerStone-002)
Kang, Eun Joo, Lee, Kyoungmin, Kim, In Ho, Kim, Ju Won, Kim, Jwa Hoon, Lee, Soohyeon, Lee, Jiwon, Shin, Kabsoo, Park, Sejun, Kim, Joori, Shin, Hyun Won, Park, Kyong Hwa
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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736 A phase 1/2 open-label, dose-escalation study of ST-067, a decoy-resistant IL-18 cytokine, given as a monotherapy and with pembrolizumab in advanced solid tumor malignancies
Moser, Justin C, Sullivan, Ryan, Taylor, Matthew H, Puzanov, Igor, Falchook, Gerald S, Sznol, Mario, Paton, Virginia E, Chonzi, David, Garofalo, Brage, Sonnemann, Mark, Uppal, Hirdesh, Barton, Jeremy, McQueen, Beatrice Y, Ring, Aaron M, Kluger, Harriet
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Abstract CT142: A phase I open-label, dose escalation study of a novel peptide (SOR-C13) antagonistic to the TRPV6 ion channel in patients with advanced solid tumor cancers
Fu, Siqing, Hirte, Hal H., Welch, Stephen, Ilenchuk, Toney T., Dugourd, Dominique, Lutes, Tyler, Rice, Christopher, Stewart, Jack M.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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A phase I and pharmacokinetic study of multiple schedules of ganetespib (STA-9090), a heat shock protein 90 inhibitor, in combination with docetaxel for subjects with advanced solid tumor malignancies
Kauh, John S., Harvey, R Donald, Owonikoko, Taofeek Kunle, El-Rayes, Bassel F., Shin, Dong Moon, Murali, Sujatha, Lewis, Colleen Margaret, Karol, Michael D., Teofilovici, Florentina, Du, Yuhong, Fu, Haian, Khuri, Fadlo Raja, Ramalingam, Suresh S.
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Clinical Trial: Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies
Published in US Fed News Service, Including US State News
(18.09.2019)
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