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Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects
Bian, Yicong, Zhang, Hua, Ma, Sheng, Jiao, Yongyi, Yan, Pangke, Liu, Xiao, Ma, Shiping, Xiong, Yating, Gu, Zheming, Yu, Zhenwen, Huang, Chenrong, Miao, Liyan
Published in British journal of clinical pharmacology (01.01.2021)
Published in British journal of clinical pharmacology (01.01.2021)
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Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID‐19, in Healthy Subjects
Humeniuk, Rita, Mathias, Anita, Cao, Huyen, Osinusi, Anu, Shen, Gong, Chng, Estelle, Ling, John, Vu, Amanda, German, Polina
Published in Clinical and translational science (01.09.2020)
Published in Clinical and translational science (01.09.2020)
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Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects
Lindmark, Bo, Li, Xue-Qing, Bhattacharya, Chandrali, Housler, Greggory, Heijer, Maria, Bragg, Ryan A., Gränfors, Malin, Pelay-Gimeno, Marta, Vaes, Wouter H.J., Menakuru, Somasekhara, Pizzato, Patricia Ely, Ericsson, Hans, Johansson, Susanne
Published in Drug metabolism and disposition (01.08.2023)
Published in Drug metabolism and disposition (01.08.2023)
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Acute toxicity is a dose-limiting factor for intravenous polymyxin B: A safety and pharmacokinetic study in healthy Chinese subjects
Liu, Xiaofen, Chen, Yuancheng, Yang, Haijing, Li, Jian, Yu, Jicheng, Yu, Zhenwei, Cao, Guoying, Wu, Xiaojie, Wang, Yu, Wu, Hailan, Fan, Yaxin, Wang, Jingjing, Wu, Jufang, Jin, Yi, Guo, Beining, Hu, Jiali, Bian, Xingchen, Li, Xin, Zhang, Jing
Published in The Journal of infection (01.02.2021)
Published in The Journal of infection (01.02.2021)
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Pharmacokinetics of SPR206 in Plasma, Pulmonary Epithelial Lining Fluid, and Alveolar Macrophages following Intravenous Administration to Healthy Adult Subjects
Rodvold, Keith A., Bader, Justin, Bruss, Jon B., Hamed, Kamal
Published in Antimicrobial agents and chemotherapy (18.07.2023)
Published in Antimicrobial agents and chemotherapy (18.07.2023)
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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects
Griffith, David C., Loutit, Jeffery S., Morgan, Elizabeth E., Durso, Stephanie, Dudley, Michael N.
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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First‐in‐human, randomized dose‐escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF‐06480605 in healthy subjects
Banfield, Christopher, Rudin, Dan, Bhattacharya, Indranil, Goteti, Kosalaram, Li, Gang, Hassan‐Zahraee, Mina, Brown, Lisa S., Hung, Kenneth E., Pawlak, Sylvester, Lepsy, Christopher
Published in British journal of clinical pharmacology (01.04.2020)
Published in British journal of clinical pharmacology (01.04.2020)
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Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects
Holmberg, Ann Aurell, Weidolf, Lars, Necander, Sofia, Bold, Peter, Sidhu, Sharan, Pelay-Gimeno, Marta, de Ligt, Rianne A.F., Verheij, Elwin R., Jauhiainen, Alexandra, Psallidas, Ioannis, Wählby Hamrén, Ulrika, Prothon, Susanne
Published in Drug metabolism and disposition (01.02.2022)
Published in Drug metabolism and disposition (01.02.2022)
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Pharmacokinetics, Safety, and Tolerability of Intravenous Durlobactam and Sulbactam in Subjects with Renal Impairment and Healthy Matched Control Subjects
O’Donnell, John, Preston, Richard A., Mamikonyan, Grigor, Stone, Emily, Isaacs, Robin
Published in Antimicrobial agents and chemotherapy (01.09.2019)
Published in Antimicrobial agents and chemotherapy (01.09.2019)
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Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects
Rodvold, Keith A., Gotfried, Mark H., Isaacs, Robin D., O'Donnell, John P., Stone, Emily
Published in Antimicrobial agents and chemotherapy (01.11.2018)
Published in Antimicrobial agents and chemotherapy (01.11.2018)
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Randomized, Open-Label Study of the Pharmacokinetics and Safety of Oral and Intravenous Administration of Omadacycline to Healthy Subjects
Sun, Haiying, Ting, Lillian, Machineni, Surendra, Praestgaard, Jens, Kuemmell, Andreas, Stein, Daniel S., Sunkara, Gangadhar, Kovacs, Steven J., Villano, Stephen, Tanaka, S. Ken
Published in Antimicrobial agents and chemotherapy (01.12.2016)
Published in Antimicrobial agents and chemotherapy (01.12.2016)
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Pharmacokinetics and pharmacodynamics of intravenous delafloxacin in healthy subjects: model-based dose optimization
Lv, Jiong-Xian, Huang, Yi-Huan, Kafauit, Farah, Wang, Yuan-Hui, Su, Chang, Ma, Jun-Heng, Xu, Yan, Huang, Chao-Chao, Zhang, Qing, Su, Yu-Wen
Published in Antimicrobial agents and chemotherapy (09.07.2024)
Published in Antimicrobial agents and chemotherapy (09.07.2024)
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Efficacy of Radicava® IV (intravenous edaravone) in subjects with differing trajectories of disease progression in amyotrophic lateral sclerosis: Use of a novel statistical approach for post hoc analysis of a pivotal phase 3 clinical trial
Pioro, Erik P., Brooks, Benjamin Rix, Liu, Ying, Zhang, Jeffrey, Apple, Stephen
Published in Journal of the neurological sciences (15.12.2024)
Published in Journal of the neurological sciences (15.12.2024)
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Population Pharmacokinetics of Risankizumab in Healthy Volunteers and Subjects with Moderate to Severe Plaque Psoriasis: Integrated Analyses of Phase I–III Clinical Trials
Suleiman, Ahmed A., Minocha, Mukul, Khatri, Amit, Pang, Yinuo, Othman, Ahmed A.
Published in Clinical pharmacokinetics (01.10.2019)
Published in Clinical pharmacokinetics (01.10.2019)
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Discovery of the Once-Weekly Glucagon-Like Peptide‑1 (GLP-1) Analogue Semaglutide
Lau, Jesper, Bloch, Paw, Schäffer, Lauge, Pettersson, Ingrid, Spetzler, Jane, Kofoed, Jacob, Madsen, Kjeld, Knudsen, Lotte Bjerre, McGuire, James, Steensgaard, Dorte Bjerre, Strauss, Holger Martin, Gram, Dorte X, Knudsen, Sanne Møller, Nielsen, Flemming Seier, Thygesen, Peter, Reedtz-Runge, Steffen, Kruse, Thomas
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Long-term effects of secukinumab on MRI findings in relation to clinical efficacy in subjects with active ankylosing spondylitis: an observational study
Baraliakos, Xenofon, Borah, Babul, Braun, Juergen, Baeten, Dominique, Laurent, Didier, Sieper, Joachim, Emery, Paul, McInnes, Iain B, van Laar, Jacob M, Wordsworth, Paul, Wollenhaupt, Juergen, Kellner, Herbert, Colin, Laurence, Vandenhende, Francois, Radford, Kath, Hueber, Wolfgang
Published in Annals of the rheumatic diseases (01.02.2016)
Published in Annals of the rheumatic diseases (01.02.2016)
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First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28
Poirier, Nicolas, Blancho, Gilles, Hiance, Maryvonne, Mary, Caroline, Van Assche, Tim, Lempoels, Jos, Ramael, Steven, Wang, Weirong, Thepenier, Virginie, Braudeau, Cecile, Salabert, Nina, Josien, Regis, Anderson, Ian, Gourley, Ian, Soulillou, Jean-Paul, Coquoz, Didier, Vanhove, Bernard
Published in The Journal of immunology (1950) (15.12.2016)
Published in The Journal of immunology (1950) (15.12.2016)
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Metabolism, Excretion, and Pharmacokinetics of [14C]‐Cefiderocol (S‐649266), a Siderophore Cephalosporin, in Healthy Subjects Following Intravenous Administration
Miyazaki, Shiro, Katsube, Takayuki, Shen, Helen, Tomek, Charles, Narukawa, Yukitoshi
Published in Journal of clinical pharmacology (01.07.2019)
Published in Journal of clinical pharmacology (01.07.2019)
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Pharmacokinetics, Disposition, and Biotransformation of [14C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose
Trivedi, Ashit, Wahlstrom, Jan, Mackowski, Mia, Dutta, Sandeep, Lee, Edward
Published in Drug metabolism and disposition (01.08.2021)
Published in Drug metabolism and disposition (01.08.2021)
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