The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Published in Nature structural & molecular biology (01.06.2017)
Published in Nature structural & molecular biology (01.06.2017)
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Journal Article
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Nature communications (18.06.2019)
Published in Nature communications (18.06.2019)
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Journal Article
A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix
Owen, Leanna M, Adhikari, Arjun S, Patel, Mohak, Grimmer, Peter, Leijnse, Natascha, Kim, Min Cheol, Notbohm, Jacob, Franck, Christian, Dunn, Alexander R
Published in Molecular biology of the cell (07.07.2017)
Published in Molecular biology of the cell (07.07.2017)
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Journal Article
Mechanical Load Induces a 100-Fold Increase in the Rate of Collagen Proteolysis by MMP-1
Adhikari, Arjun S., Chai, Jack, Dunn, Alexander R.
Published in Journal of the American Chemical Society (16.02.2011)
Published in Journal of the American Chemical Society (16.02.2011)
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Journal Article
Molecular Tension Sensors Report Forces Generated by Single Integrin Molecules in Living Cells
Morimatsu, Masatoshi, Mekhdjian, Armen H, Adhikari, Arjun S, Dunn, Alexander R
Published in Nano letters (11.09.2013)
Published in Nano letters (11.09.2013)
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Journal Article
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Adhikari, Arjun S., Kooiker, Kristina B., Sarkar, Saswata S., Liu, Chao, Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.
Published in Cell reports (Cambridge) (13.12.2016)
Published in Cell reports (Cambridge) (13.12.2016)
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Journal Article
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
Spudich, James A, Aksel, Tural, Bartholomew, Sadie R, Nag, Suman, Kawana, Masataka, Yu, Elizabeth Choe, Sarkar, Saswata S, Sung, Jongmin, Sommese, Ruth F, Sutton, Shirley, Cho, Carol, Adhikari, Arjun S, Taylor, Rebecca, Liu, Chao, Trivedi, Darshan, Ruppel, Kathleen M
Published in Journal of experimental biology (01.01.2016)
Published in Journal of experimental biology (01.01.2016)
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Journal Article
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
Sarkar, Saswata S, Trivedi, Darshan V, Morck, Makenna M, Adhikari, Arjun S, Pasha, Shaik N, Ruppel, Kathleen M, Spudich, James A
Published in Science advances (01.04.2020)
Published in Science advances (01.04.2020)
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Journal Article
Strain Tunes Proteolytic Degradation and Diffusive Transport in Fibrin Networks
Adhikari, Arjun S, Mekhdjian, Armen H, Dunn, Alexander R
Published in Biomacromolecules (13.02.2012)
Published in Biomacromolecules (13.02.2012)
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Journal Article
Multiplexed single-molecule force proteolysis measurements using magnetic tweezers
Adhikari, Arjun S, Chai, Jack, Dunn, Alexander R
Published in Journal of visualized experiments (25.07.2012)
Published in Journal of visualized experiments (25.07.2012)
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Journal Article
Hypertrophic Cardiomyopathy Mutations Disrupt Human Beta Cardiac Myosin Intramolecular Interactions Leading to Increased Myosin Activity
Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Ruppel, Kathleen M., James, Spudich A.
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Journal Article
On the Functional Assessment of Hypertrophic Cardiomyopathy-Causing Mutations in Human β-Cardiac Myosin and the Role of Myosin Binding Protein-C
Trivedi, Darshan V., Sarkar, Saswata S., Adhikari, Arjun S., Morck, Makenna M., Kooiker, Kristina B., Bernstein, Daniel, Ruppel, Kathleen M., Spudich, James A.
Published in Biophysical journal (15.02.2019)
Published in Biophysical journal (15.02.2019)
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Journal Article
Uncovering the Molecular Interactions that Maintain the Sequestered State of Myosin and their Implication in Hypertrophic Cardiomyopathy
Trivedi, Darshan V., Nag, Suman, Sarkar, Saswata S., Adhikari, Arjun S., Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.
Published in Biophysical journal (03.02.2017)
Published in Biophysical journal (03.02.2017)
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Journal Article
Actomyosin Dynamics in 3D Traction Force Generation
Owen, Leanna M., Adhikari, Arjun S., Kim, Min Cheol, Leijnse, Natascha, Dunn, Alex R.
Published in Biophysical journal (27.01.2015)
Published in Biophysical journal (27.01.2015)
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Journal Article
The Effect of Pediatric Specific Hypertrophic Cardiomyopathy Mutations on the Biomechanics of Beta Cardiac Myosin
Adhikari, Arjun S., Bezold Kooiker, Kristina, Sutton, Shirley, Bernstein, Daniel, Leinwand, Leslie A., Ruppel, Kathleen M., Spudich, James A.
Published in Biophysical journal (16.02.2016)
Published in Biophysical journal (16.02.2016)
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Journal Article