Domain-specific insight into the recognition of BH3-death motifs by the pro-survival Bcl-2 protein
Mushtaq, Ameeq Ul, Ådén, Jörgen, Ali, Katan, Gröbner, Gerhard
Published in Biophysical journal (06.12.2022)
Published in Biophysical journal (06.12.2022)
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Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts
Chorell, Erik, Andersson, Emma, Evans, Margery L, Jain, Neha, Götheson, Anna, Åden, Jörgen, Chapman, Matthew R, Almqvist, Fredrik, Wittung-Stafshede, Pernilla
Published in PloS one (2015)
Published in PloS one (2015)
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Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2‑Pyridone Polyheterocycles Binding to α‑Synuclein and Amyloid‑β Fibrils
Adolfsson, Dan E, Tyagi, Mohit, Singh, Pardeep, Deuschmann, Adrian, Ådén, Jörgen, Gharibyan, Anna L, Jayaweera, Sanduni Wasana, Lindgren, Anders E. G, Olofsson, Anders, Almqvist, Fredrik
Published in Journal of organic chemistry (06.11.2020)
Published in Journal of organic chemistry (06.11.2020)
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Pyridine-Fused 2‑Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding
Singh, Pardeep, Adolfsson, Dan E, Ådén, Jörgen, Cairns, Andrew G, Bartens, Christian, Brännström, Kristoffer, Olofsson, Anders, Almqvist, Fredrik
Published in Journal of organic chemistry (05.04.2019)
Published in Journal of organic chemistry (05.04.2019)
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Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence
Alam, Athar, Golovliov, Igor, Javed, Eram, Kumar, Rajender, Ådén, Jörgen, Sjöstedt, Anders
Published in PLoS pathogens (01.04.2020)
Published in PLoS pathogens (01.04.2020)
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A Capped Peptide of the Aggregation Prone NAC 71-82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations
Näsström, Thomas, Ådén, Jörgen, Shibata, Fumina, Andersson, Per Ola, Karlsson, Björn C G
Published in International journal of molecular sciences (27.02.2020)
Published in International journal of molecular sciences (27.02.2020)
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Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin
Jain, Neha, Ådén, Jörgen, Nagamatsu, Kanna, Evans, Margery L., Li, Xinyi, McMichael, Brennan, Ivanova, Magdalena I., Almqvist, Fredrik, Buxbaum, Joel N., Chapman, Matthew R.
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2017)
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Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation
Singh, Pardeep, Chorell, Erik, Krishnan, K. Syam, Kindahl, Tomas, Åden, Jörgen, Wittung-Stafshede, Pernilla, Almqvist, Fredrik
Published in Organic letters (18.12.2015)
Published in Organic letters (18.12.2015)
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Intra‐striatal infusion of the small molecule alpha‐synuclein aggregator, FN075, does not enhance parkinsonism in a subclinical AAV‐alpha‐synuclein rat model
Patton, Tommy, Comini, Giulia, Narasimhan, Kaushik, Cairns, Andrew G., Ådén, Jörgen, Almqvist, Fredrik, Bemelmans, Alexis, Brouillet, Emmanuel, McKernan, Declan P., Dowd, Eilís
Published in The European journal of neuroscience (01.09.2024)
Published in The European journal of neuroscience (01.09.2024)
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Journal Article
Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts
Näsström, Thomas, Dahlberg, Tobias, Malyshev, Dmitry, Ådén, Jörgen, Andersson, Per Ola, Andersson, Magnus, Karlsson, Björn C. G.
Published in International journal of molecular sciences (01.09.2021)
Published in International journal of molecular sciences (01.09.2021)
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Journal Article
Structural Topology and Activation of an Initial Adenylate Kinase–Substrate Complex
Ådén, Jörgen, Weise, Christoph F, Brännström, Kristoffer, Olofsson, Anders, Wolf-Watz, Magnus
Published in Biochemistry (Easton) (12.02.2013)
Published in Biochemistry (Easton) (12.02.2013)
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K2S2O8-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
Bharate, Jaideep B., Aden, Jorgen, Gharibyan, Anna, Adolfsson, Dan E., Jayaweera, Sanduni Wasana, Singh, Pardeep, Vielfort, Katarina, Tyagi, Mohit, Bonde, Mari, Bergstrom, Sven, Olofsson, Anders, Almqvist, Fredrik
Published in Organic & biomolecular chemistry (18.11.2021)
Published in Organic & biomolecular chemistry (18.11.2021)
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Journal Article
Viral mimetic priming enhances α-synuclein-induced degeneration: Implications for Parkinson’s disease
Olsen, Laura K., Cairns, Andrew G., Ådén, Jörgen, Moriarty, Niamh, Cabre, Silvia, Alamilla, Veronica R., Almqvist, Fredrik, Dowd, Eilís, McKernan, Declan P.
Published in Brain, behavior, and immunity (01.08.2019)
Published in Brain, behavior, and immunity (01.08.2019)
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Journal Article
The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models
Kelly, Rachel, Cairns, Andrew G, Ådén, Jörgen, Almqvist, Fredrik, Bemelmans, Alexis-Pierre, Brouillet, Emmanuel, Patton, Tommy, McKernan, Declan P, Dowd, Eilís
Published in Biomolecules (Basel, Switzerland) (12.11.2021)
Published in Biomolecules (Basel, Switzerland) (12.11.2021)
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Journal Article
Creation of distinctive Bax-lipid complexes at mitochondrial membrane surfaces drives pore formation to initiate apoptosis
Clifton, Luke A, Wacklin-Knecht, Hanna P, Ådén, Jörgen, Mushtaq, Ameeq Ul, Sparrman, Tobias, Gröbner, Gerhard
Published in Science advances (02.06.2023)
Published in Science advances (02.06.2023)
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