Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis
Latham, Amanda S, Geer, Charlize E, Ackart, David F, Anderson, Isla K, Vittoria, Kaley M, Podell, Brendan K, Basaraba, Randall J, Moreno, Julie A
Published in Frontiers in neuroscience (19.05.2023)
Published in Frontiers in neuroscience (19.05.2023)
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Journal Article
2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain
Jeon, Albert Byungyun, Ackart, David F, Li, Wei, Jackson, Mary, Melander, Roberta J, Melander, Christian, Abramovitch, Robert B, Chicco, Adam J, Basaraba, Randall J, Obregón-Henao, Andrés
Published in Scientific reports (06.02.2019)
Published in Scientific reports (06.02.2019)
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Journal Article
Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis
Frenkel, Jessica D Haugen, Ackart, David F, Todd, Alexandra K, DiLisio, James E, Hoffman, Siana, Tanner, Samantha, Kiran, Dilara, Murray, Megan, Chicco, Adam, Obregón-Henao, Andrés, Podell, Brendan K, Basaraba, Randall J
Published in Scientific reports (01.10.2020)
Published in Scientific reports (01.10.2020)
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Journal Article
A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
Podell, Brendan K, Ackart, David F, Richardson, Michael A, DiLisio, James E, Pulford, Bruce, Basaraba, Randall J
Published in Disease models & mechanisms (01.02.2017)
Published in Disease models & mechanisms (01.02.2017)
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Journal Article
2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability
Jeon, Albert B, Obregón-Henao, Andrés, Ackart, David F, Podell, Brendan K, Belardinelli, Juan M, Jackson, Mary, Nguyen, Tuan V, Blackledge, Meghan S, Melander, Roberta J, Melander, Christian, Johnson, Benjamin K, Abramovitch, Robert B, Basaraba, Randall J
Published in PloS one (27.07.2017)
Published in PloS one (27.07.2017)
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Journal Article
Uptake and accumulation of oxidized low-density lipoprotein during Mycobacterium tuberculosis infection in guinea pigs
Palanisamy, Gopinath S, Kirk, Natalie M, Ackart, David F, Obregón-Henao, Andrés, Shanley, Crystal A, Orme, Ian M, Basaraba, Randall J
Published in PloS one (30.03.2012)
Published in PloS one (30.03.2012)
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Journal Article
Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection
Butler, Molly, Chotiwan, Nunya, Brewster, Connie D, DiLisio, James E, Ackart, David F, Podell, Brendan K, Basaraba, Randall J, Perera, Rushika, Quackenbush, Sandra L, Rovnak, Joel
Published in Viruses (17.06.2020)
Published in Viruses (17.06.2020)
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Journal Article
An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis
Sefat, K M Samiur Rahman, Kumar, Monish, Kehl, Stephanie, Kulkarni, Rohan, Leekha, Ankita, Paniagua, Melisa-Martinez, Ackart, David F., Jones, Nicole, Spencer, Charles, Podell, Brendan K, Ouellet, Hugues, Varadarajan, Navin
Published in Vaccine (17.09.2024)
Published in Vaccine (17.09.2024)
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Journal Article
The Impact of Vitamin A Deficiency on Tuberculosis Progression
Podell, Brendan K, Aibana, Omowunmi, Huang, Chuan-Chin, DiLisio, James E, Harris, Macallister C, Ackart, David F, Armann, Kody, Grover, Alexander, Severe, Patrice, Juste, Marc Antoine Jean, Dupnik, Kathryn, Basaraba, Randall J, Murray, Megan B
Published in Clinical infectious diseases (19.12.2022)
Published in Clinical infectious diseases (19.12.2022)
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Journal Article
Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity
Podell, Brendan K, Ackart, David F, Obregon-Henao, Andres, Eck, Sarah P, Henao-Tamayo, Marcela, Richardson, Michael, Orme, Ian M, Ordway, Diane J, Basaraba, Randall J
Published in The American journal of pathology (01.04.2014)
Published in The American journal of pathology (01.04.2014)
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Journal Article
The Discovery of 2‐Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β‐Lactam Antibiotics in a Pattern Distinct from β‐Lactamase Inhibitors
Nguyen, T. Vu, Blackledge, Meghan S., Lindsey, Erick A., Minrovic, Bradley M., Ackart, David F., Jeon, Albert B., Obregón‐Henao, Andrés, Melander, Roberta J., Basaraba, Randall J., Melander, Christian
Published in Angewandte Chemie International Edition (27.03.2017)
Published in Angewandte Chemie International Edition (27.03.2017)
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Journal Article
Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis
Ackart, David F., Hascall-Dove, Laurel, Caceres, Silvia M., Kirk, Natalie M., Podell, Brendan K., Melander, Christian, Orme, Ian M., Leid, Jeff G., Nick, Jerry A., Basaraba, Randall J.
Published in Pathogens and disease (01.04.2014)
Published in Pathogens and disease (01.04.2014)
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Journal Article
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules
Ackart, David F., Lindsey, Erick A., Podell, Brendan K., Melander, Roberta J., Basaraba, Randall J., Melander, Christian
Published in Pathogens and disease (01.04.2014)
Published in Pathogens and disease (01.04.2014)
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Journal Article
Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis
Brackett, Sara M, Cox, Karlie E, Barlock, Samantha L, Huggins, William M, Ackart, David F, Bassaraba, Randall J, Melander, Roberta J, Melander, Christian
Published in MedChemComm (01.01.2020)
Published in MedChemComm (01.01.2020)
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Journal Article
Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers
Furlani, Robert E., Richardson, Mike A., Podell, Brendan K., Ackart, David F., Haugen, Jessica D., Melander, Roberta J., Basaraba, Randall J., Melander, Christian
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Journal Article
Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives
Richardson, Mike A., Furlani, Robert E., Podell, Brendan K., Ackart, David F., Haugen, Jessica D., Melander, Roberta J., Melander, Christian, Basaraba, Randall J.
Published in Tetrahedron letters (03.06.2015)
Published in Tetrahedron letters (03.06.2015)
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Journal Article
Increased Severity of Tuberculosis in Guinea Pigs with Type 2 Diabetes
Podell, Brendan K, Ackart, David F, Obregon-Henao, Andres, Eck, Sarah P, Henao-Tamayo, Marcela, Richardson, Michael, Orme, Ian M, Ordway, Diane J, Basaraba, Randall J
Published in The American journal of pathology (01.04.2014)
Published in The American journal of pathology (01.04.2014)
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Journal Article
The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M.tuberculosis to beta -Lactam Antibiotics in a Pattern Distinct from beta -Lactamase Inhibitors
Nguyen, TVu, Blackledge, Meghan S, Lindsey, Erick A, Minrovic, Bradley M, Ackart, David F, Jeon, Albert B, Obregon-Henao, Andres, Melander, Roberta J, Basaraba, Randall J, Melander, Christian
Published in Angewandte Chemie International Edition (01.03.2017)
Published in Angewandte Chemie International Edition (01.03.2017)
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