Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity
Otsomaa, Leena, Levijoki, Jouko, Wohlfahrt, Gerd, Chapman, Hugh, Koivisto, Ari‐Pekka, Syrjänen, Kaisa, Koskelainen, Tuula, Peltokorpi, Saara‐Elisa, Finckenberg, Piet, Heikkilä, Aira, Abi‐Gerges, Najah, Ghetti, Andre, Miller, Paul E., Page, Guy, Mervaala, Eero, Nagy, Norbert, Kohajda, Zsófia, Jost, Norbert, Virág, László, Varró, András, Papp, Julius Gy
Published in British journal of pharmacology (01.12.2020)
Published in British journal of pharmacology (01.12.2020)
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Journal Article
Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
Ton, Anh Tuan, Nguyen, William, Sweat, Katrina, Miron, Yannick, Hernandez, Eduardo, Wong, Tiara, Geft, Valentyna, Macias, Andrew, Espinoza, Ana, Truong, Ky, Rasoul, Lana, Stafford, Alexa, Cotta, Tamara, Mai, Christina, Indersmitten, Tim, Page, Guy, Miller, Paul E., Ghetti, Andre, Abi-Gerges, Najah
Published in Scientific reports (08.06.2021)
Published in Scientific reports (08.06.2021)
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Journal Article
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm
Fermini, Bernard, Hancox, Jules C, Abi-Gerges, Najah, Bridgland-Taylor, Matthew, Chaudhary, Khuram W, Colatsky, Thomas, Correll, Krystle, Crumb, William, Damiano, Bruce, Erdemli, Gul, Gintant, Gary, Imredy, John, Koerner, John, Kramer, James, Levesque, Paul, Li, Zhihua, Lindqvist, Anders, Obejero-Paz, Carlos A, Rampe, David, Sawada, Kohei, Strauss, David G, Vandenberg, Jamie I
Published in Journal of biomolecular screening (01.01.2016)
Published in Journal of biomolecular screening (01.01.2016)
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Journal Article
Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes
Abi Gerges, Najah, Stafford, Alexa, Truong, Ky, Miron, Yannick, Winrow, Bryce, Krause, Brian, Page, Guy, Ghetti, Andre
Published in Journal of visualized experiments (09.08.2022)
Published in Journal of visualized experiments (09.08.2022)
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Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk
Nguyen, Nathalie, Nguyen, William, Nguyenton, Brynna, Ratchada, Phachareeya, Page, Guy, Miller, Paul E, Ghetti, Andre, Abi-Gerges, Najah
Published in Frontiers in physiology (19.12.2017)
Published in Frontiers in physiology (19.12.2017)
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Journal Article
Multiparametric Mechanistic Profiling of Inotropic Drugs in Adult Human Primary Cardiomyocytes
Abi-Gerges, Najah, Indersmitten, Tim, Truong, Ky, Nguyen, William, Ratchada, Phachareeya, Nguyen, Nathalie, Page, Guy, Miller, Paul E, Ghetti, Andre
Published in Scientific reports (06.05.2020)
Published in Scientific reports (06.05.2020)
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Journal Article
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
Havel, Václav, Kruegel, Andrew C, Bechand, Benjamin, McIntosh, Scot, Stallings, Leia, Hodges, Alana, Wulf, Madalee G, Nelson, Mel, Hunkele, Amanda, Ansonoff, Michael, Pintar, John E, Hwu, Christopher, Ople, Rohini S, Abi-Gerges, Najah, Zaidi, Saheem A, Katritch, Vsevolod, Yang, Mu, Javitch, Jonathan A, Majumdar, Susruta, Hemby, Scott E, Sames, Dalibor
Published in Nature communications (20.09.2024)
Published in Nature communications (20.09.2024)
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Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability
Britton, Oliver J, Abi-Gerges, Najah, Page, Guy, Ghetti, Andre, Miller, Paul E, Rodriguez, Blanca
Published in Frontiers in physiology (18.08.2017)
Published in Frontiers in physiology (18.08.2017)
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Journal Article
Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes
Schmid, Christina, Abi-Gerges, Najah, Leitner, Michael Georg, Zellner, Dietmar, Rast, Georg
Published in Cells (Basel, Switzerland) (30.11.2021)
Published in Cells (Basel, Switzerland) (30.11.2021)
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Journal Article
Prediction of Thorough QT study results using action potential simulations based on ion channel screens
Mirams, Gary R., Davies, Mark R., Brough, Stephen J., Bridgland-Taylor, Matthew H., Cui, Yi, Gavaghan, David J., Abi-Gerges, Najah
Published in Journal of pharmacological and toxicological methods (01.11.2014)
Published in Journal of pharmacological and toxicological methods (01.11.2014)
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hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment
DI VEROLI, GIOVANNI Y., DAVIES, MARK R., ZHANG, HENGGUI, ABI-GERGES, NAJAH, BOYETT, MARK R.
Published in Journal of cardiovascular electrophysiology (01.02.2014)
Published in Journal of cardiovascular electrophysiology (01.02.2014)
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Journal Article
Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae
Qu, Yusheng, Page, Guy, Abi-Gerges, Najah, Miller, Paul E, Ghetti, Andre, Vargas, Hugo M
Published in Frontiers in physiology (05.01.2018)
Published in Frontiers in physiology (05.01.2018)
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Journal Article
Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century
Hill, Adam P., Perry, Matthew D., Abi‐Gerges, Najah, Couderc, Jean‐Philippe, Fermini, Bernard, Hancox, Jules C., Knollmann, Bjorn C., Mirams, Gary R., Skinner, Jon, Zareba, Wojciech, Vandenberg, Jamie I.
Published in The Journal of physiology (01.12.2016)
Published in The Journal of physiology (01.12.2016)
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Journal Article
Human ex-vivo action potential model for pro-arrhythmia risk assessment
Page, Guy, Ratchada, Phachareeya, Miron, Yannick, Steiner, Guido, Ghetti, Andre, Miller, Paul E., Reynolds, Jack A., Wang, Ken, Greiter-Wilke, Andrea, Polonchuk, Liudmila, Traebert, Martin, Gintant, Gary A., Abi-Gerges, Najah
Published in Journal of pharmacological and toxicological methods (01.09.2016)
Published in Journal of pharmacological and toxicological methods (01.09.2016)
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