Revisiting the hERG safety margin after 20 years of routine hERG screening
Leishman, Derek J., Abernathy, Matthew M., Wang, Evan B.
Published in Journal of pharmacological and toxicological methods (01.09.2020)
Published in Journal of pharmacological and toxicological methods (01.09.2020)
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The failure to detect drug-induced sensory loss in standard preclinical studies
Gauvin, David V., Abernathy, Matthew M., Tapp, Rachel L., Yoder, Joshua D., Dalton, Jill A., Baird, Theodore J.
Published in Journal of pharmacological and toxicological methods (01.07.2015)
Published in Journal of pharmacological and toxicological methods (01.07.2015)
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Journal Article
Return to SENDer: The Submitted Electronic Data for Nonclinical Cardiovascular Studies is Not Facilitating Transparency, Translation or Innovation
Abernathy, Matthew M, Best, Derek D, Leishman, Derek J
Published in Clinical pharmacology and therapeutics (01.11.2024)
Published in Clinical pharmacology and therapeutics (01.11.2024)
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Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation
Holdsworth, David, Best, Derek D., Haist, Katarina, O'Donohue, Kyle, Phillips, Anson, Abernathy, Matthew M., Roche, Brian, Leishman, Derek J.
Published in Journal of pharmacological and toxicological methods (01.03.2023)
Published in Journal of pharmacological and toxicological methods (01.03.2023)
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Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure
Verdino, Petra, Lee, Stacey L., Cooper, Fariba N., Cottle, Steven R., Grealish, Patrick F., Hu, Charlie C., Meyer, Catalina M., Lin, Joanne, Copeland, Victoria, Porter, Gina, Schroeder, Richard L., Thompson, Tyran D., Porras, Leah L., Dey, Asim, Zhang, Hong Y., Beebe, Emily C., Matkovich, Scot J., Coskun, Tamer, Balciunas, Aldona M., Ferrante, Andrea, Siegel, Robert, Malherbe, Laurent, Bivi, Nicoletta, Paavola, Chad D., Hansen, Ryan J., Abernathy, Matthew M., Nwosu, Sylvia O., Carr, Molly C., Heuer, Josef G., Wang, Xiaojun
Published in British journal of pharmacology (01.08.2023)
Published in British journal of pharmacology (01.08.2023)
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The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis
Boulay, Emmanuel, Miraucourt, Loïs S., Pugsley, Michael K., Abernathy, Matthew M., Chui, Ray, Dalton, Jill, Demers, Marjorie, Dybdal, Noel, Gazaille, Elissa, Greiter-Wilke, Andrea, Hoffmann, Peter, Huang, Hai, LaDuke, Carrie, Norton, Kevin, Pierson, Jennifer B., Reeves, Isabelle, Roche, Brian, Rossman, Eric I., Schultze, Albert E., Tang, Hai-Ming, Wisialowski, Todd, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.05.2023)
Published in Journal of pharmacological and toxicological methods (01.05.2023)
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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective
Reynolds, Vincent L., Butler, Paul, Abernathy, Matthew M., Aschenbrenner, Laura, Best, Derek D., Blank, Jim, Crosby, Meredith, Custer, Laura, Escobar, Patricia A., Kolaja, Kyle, Moggs, Jonathan, Shuey, Dana, Snyder, Chelsea, Van Vleet, Terry, Zhou, Junguo, Hart, Timothy K.
Published in Regulatory toxicology and pharmacology (01.11.2020)
Published in Regulatory toxicology and pharmacology (01.11.2020)
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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium
Boulay, Emmanuel, Abernathy, Matthew M, Chui, Ray, Friedrichs, Gregory S, Gendron-Parra, Nicolas, Greiter-Wilke, Andrea, Guillon, Jean-Michel, Koerner, John E, Menard, Ariane, Steidl-Nichols, Jill, Pierson, Jennifer, Pugsley, Michael K, Rossman, Eric I, Strauss, David, Troncy, Eric, Valentin, Jean-Pierre, Wisialowski, Todd, Authier, Simon
Published in International journal of toxicology (01.01.2019)
Published in International journal of toxicology (01.01.2019)
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An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation
Authier, Simon, Abernathy, Matthew M, Correll, Krystle, Chui, Ray W, Dalton, Jill, Foley, C Michael, Friedrichs, Gregory S, Koerner, John E, Kallman, Mary-Jeanne, Pannirselvam, Malar, Redfern, William S, Urmaliya, Vijay, Valentin, Jean-Pierre, Wisialowski, Todd, Zabka, Tanja S, Pugsley, Michael K
Published in International journal of toxicology (01.07.2020)
Published in International journal of toxicology (01.07.2020)
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A sub-peritoneal approach to telemetry implantation in minipigs: Impact on body temperature and the QTc/CBT relationship
Dalton, Jill A., Moddrelle, David S., O'Donohue, Kyle P., Galbraith, Brandon M., Ward, Scott W., Abernathy, Matthew M., Phillips, Anson L., Baird, Theodore J.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
An evaluation of staining procedures for cytocochleogram analysis of middle ear organ of corti surface preparations
Tapp, Rachel L., Abernathy, Matthew M., Yoder, Joshua D., Koch, Andrea A., Tack, Stephanie M., Voci, Richard N., Toman, Brett L., Cole, Phaedra I., Gregorich, Derek J., Gauvin, David V., Baird, Theodore J.
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
A comparison of baseline cardiovascular parameters and the sensitivity to detect changes in systemic blood pressure and heart rate in beagle dogs using DSI M11 disposable telemetry devices
Sadekova, Nataliya, Abernathy, Matthew M., Leishman, Derek, Norton, Kevin
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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