Diazepam is not a direct allosteric modulator of α 1 -adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4
Williams, Lisa M, He, Xiaoji, Vaid, Tasneem M, Abdul-Ridha, Alaa, Whitehead, Alice R, Gooley, Paul R, Bathgate, Ross A D, Williams, Spencer J, Scott, Daniel J
Published in Pharmacology research & perspectives (01.02.2019)
Published in Pharmacology research & perspectives (01.02.2019)
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Journal Article
Diazepam is not a direct allosteric modulator of α1‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4
Williams, Lisa M., He, Xiaoji, Vaid, Tasneem M., Abdul‐Ridha, Alaa, Whitehead, Alice R., Gooley, Paul R., Bathgate, Ross A.D., Williams, Spencer J., Scott, Daniel J.
Published in Pharmacology research & perspectives (01.02.2019)
Published in Pharmacology research & perspectives (01.02.2019)
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Journal Article
Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches
Wu, Feng-Jie, Williams, Lisa M., Abdul-Ridha, Alaa, Gunatilaka, Avanka, Vaid, Tasneem M., Kocan, Martina, Whitehead, Alice R., Griffin, Michael D.W., Bathgate, Ross A.D., Scott, Daniel J., Gooley, Paul R.
Published in The Journal of biological chemistry (22.05.2020)
Published in The Journal of biological chemistry (22.05.2020)
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Journal Article
Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs
van der Peet, Phillip L., Gunawan, Christian, Abdul-Ridha, Alaa, Ma, Sherie, Scott, Daniel J., Gundlach, Andrew L., Bathgate, Ross A.D., White, Jonathan M., Williams, Spencer J.
Published in MethodsX (01.01.2018)
Published in MethodsX (01.01.2018)
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The 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist
Betrie, Ashenafi H., Abdul-Ridha, Alaa, Hartono, Herodion, Chalmers, David K., Wright, Christine E., Scott, Daniel J., Angus, James A., Ayton, Scott
Published in Biochemical pharmacology (01.04.2024)
Published in Biochemical pharmacology (01.04.2024)
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Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor
Abdul-Ridha, Alaa, Lane, J.Robert, Mistry, Shailesh N., López, Laura, Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur, Canals, Meritxell
Published in The Journal of biological chemistry (28.11.2014)
Published in The Journal of biological chemistry (28.11.2014)
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Journal Article
Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor
Abdul-Ridha, Alaa, López, Laura, Keov, Peter, Thal, David M., Mistry, Shailesh N., Sexton, Patrick M., Lane, J. Robert, Canals, Meritxell, Christopoulos, Arthur
Published in The Journal of biological chemistry (28.02.2014)
Published in The Journal of biological chemistry (28.02.2014)
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Journal Article
Identification of a Novel Subtype-Selective α 1B -Adrenoceptor Antagonist
Abdul-Ridha, Alaa, de Zhang, Lazarus A, Betrie, Ashenafi Haileyesus, Deluigi, Mattia, Vaid, Tasneem M, Whitehead, Alice, Zhang, Yifan, Davis, Ben, Harris, Richard, Simmonite, Heather, Hubbard, Roderick E, Gooley, Paul R, Plückthun, Andreas, Bathgate, Ross A D, Chalmers, David K, Scott, Daniel J
Published in ACS chemical neuroscience (07.02.2024)
Published in ACS chemical neuroscience (07.02.2024)
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Journal Article
Regulation of G Protein-Coupled Receptors by Allosteric Ligands
Lane, J. Robert, Abdul-Ridha, Alaa, Canals, Meritxell
Published in ACS chemical neuroscience (17.04.2013)
Published in ACS chemical neuroscience (17.04.2013)
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Journal Article
Novel Irreversible Agonists Acting at the A1 Adenosine Receptor
Jörg, Manuela, Glukhova, Alisa, Abdul-Ridha, Alaa, Vecchio, Elizabeth A, Nguyen, Anh T. N, Sexton, Patrick M, White, Paul J, May, Lauren T, Christopoulos, Arthur, Scammells, Peter J
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Journal Article
Allosteric modulation of a chemogenetically modified G protein-coupled receptor
Abdul-Ridha, Alaa, Lane, J Robert, Sexton, Patrick M, Canals, Meritxell, Christopoulos, Arthur
Published in Molecular pharmacology (01.02.2013)
Published in Molecular pharmacology (01.02.2013)
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Journal Article
Identification of a Novel Subtype-Selective α1B-Adrenoceptor Antagonist
Abdul-Ridha, Alaa, de Zhang, Lazarus A., Betrie, Ashenafi Haileyesus, Deluigi, Mattia, Vaid, Tasneem M., Whitehead, Alice, Zhang, Yifan, Davis, Ben, Harris, Richard, Simmonite, Heather, Hubbard, Roderick E., Gooley, Paul R., Plückthun, Andreas, Bathgate, Ross A.D., Chalmers, David K., Scott, Daniel J.
Published in ACS chemical neuroscience (07.02.2024)
Published in ACS chemical neuroscience (07.02.2024)
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Journal Article
Novel Irreversible Agonists Acting at the A 1 Adenosine Receptor
Jörg, Manuela, Glukhova, Alisa, Abdul-Ridha, Alaa, Vecchio, Elizabeth A, Nguyen, Anh T N, Sexton, Patrick M, White, Paul J, May, Lauren T, Christopoulos, Arthur, Scammells, Peter J
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Journal Article
Probing the correlation between ligand efficacy and conformational diversity at the α 1A -adrenoreceptor reveals allosteric coupling of its microswitches
Wu, Feng-Jie, Williams, Lisa M, Abdul-Ridha, Alaa, Gunatilaka, Avanka, Vaid, Tasneem M, Kocan, Martina, Whitehead, Alice R, Griffin, Michael D W, Bathgate, Ross A D, Scott, Daniel J, Gooley, Paul R
Published in The Journal of biological chemistry (22.05.2020)
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Published in The Journal of biological chemistry (22.05.2020)
Journal Article
Probing the correlation between ligand efficacy and conformational diversity at the α 1A -adrenoreceptor reveals allosteric coupling of its microswitches
Wu, Feng-Jie, Williams, Lisa M, Abdul-Ridha, Alaa, Gunatilaka, Avanka, Vaid, Tasneem M, Kocan, Martina, Whitehead, Alice R, Griffin, Michael D W, Bathgate, Ross A D, Scott, Daniel J, Gooley, Paul R
Published in The Journal of biological chemistry (22.05.2020)
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Published in The Journal of biological chemistry (22.05.2020)
Journal Article
α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism
Gooley, Paul R, Wu, Fengjie, Williams, Lisa M, Abdul-Ridha, Alaa, Gunatilaka, Avanka, Vaid, Tasneem M, Kocan, Martina, Whitehead, Alice R, Griffin, Mike, Ross Ad Bathgate, Scott, Daniel J
Published in bioRxiv (07.12.2019)
Published in bioRxiv (07.12.2019)
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