Biased Opioid Ligands
Faouzi, Abdelfattah, Varga, Balazs R, Majumdar, Susruta
Published in Molecules (Basel, Switzerland) (16.09.2020)
Published in Molecules (Basel, Switzerland) (16.09.2020)
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Journal Article
Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
Bhowmik, Srijita, Galeta, Juraj, Havel, Václav, Nelson, Melissa, Faouzi, Abdelfattah, Bechand, Benjamin, Ansonoff, Mike, Fiala, Tomas, Hunkele, Amanda, Kruegel, Andrew C, Pintar, John E, Majumdar, Susruta, Javitch, Jonathan A, Sames, Dalibor
Published in Nature communications (22.06.2021)
Published in Nature communications (22.06.2021)
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Journal Article
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
Uprety, Rajendra, Che, Tao, Zaidi, Saheem A, Grinnell, Steven G, Varga, Balázs R, Faouzi, Abdelfattah, Slocum, Samuel T, Allaoa, Abdullah, Varadi, András, Nelson, Melissa, Bernhard, Sarah M, Kulko, Elizaveta, Le Rouzic, Valerie, Eans, Shainnel O, Simons, Chloe A, Hunkele, Amanda, Subrath, Joan, Pan, Ying Xian, Javitch, Jonathan A, McLaughlin, Jay P, Roth, Bryan L, Pasternak, Gavril W, Katritch, Vsevolod, Majumdar, Susruta
Published in eLife (08.02.2021)
Published in eLife (08.02.2021)
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Journal Article
Think Big, Start Small: How Nanomedicine Could Alleviate the Burden of Rare CNS Diseases
Faouzi, Abdelfattah, Roullin, Valérie Gaëlle
Published in Pharmaceuticals (Basel, Switzerland) (30.01.2021)
Published in Pharmaceuticals (Basel, Switzerland) (30.01.2021)
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Journal Article
Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit
Do, Cong Viet, Faouzi, Abdelfattah, Barette, Caroline, Farce, Amaury, Fauvarque, Marie-Odile, Colomb, Evelyne, Catry, Laura, Berthier-Vergnes, Odile, Haftek, Marek, Barret, Roland, Lomberget, Thierry
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Journal Article
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR
Ople, Rohini S., Ramos-Gonzalez, Nokomis, Li, Qiongyu, Sobecks, Briana L., Aydin, Deniz, Powers, Alexander S., Faouzi, Abdelfattah, Polacco, Benjamin J., Bernhard, Sarah M., Appourchaux, Kevin, Sribhashyam, Sashrik, Eans, Shainnel O., Tsai, Bowen A., Dror, Ron O., Varga, Balazs R., Wang, Haoqing, Hüttenhain, Ruth, McLaughlin, Jay P., Majumdar, Susruta
Published in ACS central science (28.08.2024)
Published in ACS central science (28.08.2024)
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Journal Article
Structure-based design of bitopic ligands for the µ-opioid receptor
Faouzi, Abdelfattah, Wang, Haoqing, Zaidi, Saheem A, DiBerto, Jeffrey F, Che, Tao, Qu, Qianhui, Robertson, Michael J, Madasu, Manish K, El Daibani, Amal, Varga, Balazs R, Zhang, Tiffany, Ruiz, Claudia, Liu, Shan, Xu, Jin, Appourchaux, Kevin, Slocum, Samuel T, Eans, Shainnel O, Cameron, Michael D, Al-Hasani, Ream, Pan, Ying Xian, Roth, Bryan L, McLaughlin, Jay P, Skiniotis, Georgios, Katritch, Vsevolod, Kobilka, Brian K, Majumdar, Susruta
Published in Nature (London) (26.01.2023)
Published in Nature (London) (26.01.2023)
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Journal Article
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects
Chakraborty, Soumen, DiBerto, Jeffrey F, Faouzi, Abdelfattah, Bernhard, Sarah M, Gutridge, Anna M, Ramsey, Steven, Zhou, Yuchen, Provasi, Davide, Nuthikattu, Nitin, Jilakara, Rahul, Nelson, Melissa N. F, Asher, Wesley B, Eans, Shainnel O, Wilson, Lisa L, Chintala, Satyanarayana M, Filizola, Marta, van Rijn, Richard M, Margolis, Elyssa B, Roth, Bryan L, McLaughlin, Jay P, Che, Tao, Sames, Dalibor, Javitch, Jonathan A, Majumdar, Susruta
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies
Faouzi, Abdelfattah, Arnaud, Alexandre, Bancet, Alexandre, Barette, Caroline, Preto, Jordane, Do, Cong Viet, Jordheim, Lars Petter, Bousfiha, Zineb, Nguyen, Thi Thanh Binh, Verrière, Marion, Farce, Amaury, Fauvarque, Marie-Odile, Barret, Roland, Lomberget, Thierry
Published in European journal of medicinal chemistry (05.04.2021)
Published in European journal of medicinal chemistry (05.04.2021)
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Journal Article
A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects
Chakraborty, Soumen, Diberto, Jeffrey F, Abdelfattah Faouzi, Bernhard, Sarah M, Gutridge, Anna M, Ramsey, Steven, Zhou, Yuchen, Provasi, Davide, Nuthikattu, Nitin, Jilakara, Rahul, Nelson, Melissa, Asher, Wesley B, Eans, Shainnel O, Wilson, Lisa L, Chintala, Satyanarayana M, Filizola, Marta, Van Rijn, Richard M, Margolis, Elyssa B, Roth, Bryan L, Mclaughlin, Jay P, Javitch, Jonathan A, Che, Tao, Majumdar, Susruta
Published in bioRxiv (22.04.2021)
Published in bioRxiv (22.04.2021)
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