Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
Yeh, Tzu-Lan, Leissing, Thomas M, Abboud, Martine I, Thinnes, Cyrille C, Atasoylu, Onur, Holt-Martyn, James P, Zhang, Dong, Tumber, Anthony, Lippl, Kerstin, Lohans, Christopher T, Leung, Ivanhoe K H, Morcrette, Helen, Clifton, Ian J, Claridge, Timothy D W, Kawamura, Akane, Flashman, Emily, Lu, Xin, Ratcliffe, Peter J, Chowdhury, Rasheduzzaman, Pugh, Christopher W, Schofield, Christopher J
Published in Chemical science (Cambridge) (2017)
Published in Chemical science (Cambridge) (2017)
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Journal Article
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Chowdhury, Rasheduzzaman, Leung, Ivanhoe K. H., Tian, Ya-Min, Abboud, Martine I., Ge, Wei, Domene, Carmen, Cantrelle, François-Xavier, Landrieu, Isabelle, Hardy, Adam P., Pugh, Christopher W., Ratcliffe, Peter J., Claridge, Timothy D. W., Schofield, Christopher J.
Published in Nature communications (26.08.2016)
Published in Nature communications (26.08.2016)
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Journal Article
Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors
Reinbold, Raphael, Hvinden, Ingvild C., Rabe, Patrick, Herold, Ryan A., Finch, Alina, Wood, James, Morgan, Melissa, Staudt, Maximillian, Clifton, Ian J., Armstrong, Fraser A., McCullagh, James S. O., Redmond, Jo, Bardella, Chiara, Abboud, Martine I., Schofield, Christopher J.
Published in Nature communications (15.08.2022)
Published in Nature communications (15.08.2022)
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Journal Article
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Cockman, Matthew E, Lippl, Kerstin, Tian, Ya-Min, Pegg, Hamish B, Figg, Jnr, William D, Abboud, Martine I, Heilig, Raphael, Fischer, Roman, Myllyharju, Johanna, Schofield, Christopher J, Ratcliffe, Peter J
Published in eLife (10.09.2019)
Published in eLife (10.09.2019)
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Journal Article
Targeting Protein-Protein Interactions in the HIF System
Wilkins, Sarah E., Abboud, Martine I., Hancock, Rebecca L., Schofield, Christopher J.
Published in ChemMedChem (19.04.2016)
Published in ChemMedChem (19.04.2016)
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Journal Article
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
Abboud, Martine I, McAllister, Tom E, Leung, Ivanhoe K. H, Chowdhury, Rasheduzzaman, Jorgensen, Christian, Domene, Carmen, Mecinovi, Jasmin, Lippl, Kerstin, Hancock, Rebecca L, Hopkinson, Richard J, Kawamura, Akane, Claridge, Timothy D. W, Schofield, Christopher J
Published in Chemical communications (Cambridge, England) (2018)
Published in Chemical communications (Cambridge, England) (2018)
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Journal Article
Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2
Chowdhury, Rasheduzzaman, Abboud, Martine I., McAllister, Tom E., Banerji, Biswadip, Bhushan, Bhaskar, Sorensen, John L., Kawamura, Akane, Schofield, Christopher J.
Published in Scientific reports (15.12.2020)
Published in Scientific reports (15.12.2020)
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Journal Article
Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells
Walsby-Tickle, John, Gannon, Joan, Hvinden, Ingvild, Bardella, Chiara, Abboud, Martine I., Nazeer, Areesha, Hauton, David, Pires, Elisabete, Cadoux-Hudson, Tom, Schofield, Christopher J., McCullagh, James S. O.
Published in Communications biology (20.05.2020)
Published in Communications biology (20.05.2020)
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Journal Article
The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases
Roatsch, Martin, Hoffmann, Inga, Abboud, Martine I, Hancock, Rebecca L, Tarhonskaya, Hanna, Hsu, Kuo-Feng, Wilkins, Sarah E, Yeh, Tzu-Lan, Lippl, Kerstin, Serrer, Kerstin, Moneke, Isabelle, Ahrens, Theresa D, Robaa, Dina, Wenzler, Sandra, Barthes, Nicolas P. F, Franz, Henriette, Sippl, Wolfgang, Lassmann, Silke, Diederichs, Sven, Schleicher, Erik, Schofield, Christopher J, Kawamura, Akane, Schüle, Roland, Jung, Manfred
Published in ACS chemical biology (16.08.2019)
Published in ACS chemical biology (16.08.2019)
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Journal Article
Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
Liu, Shuang, Abboud, Martine I., John, Tobias, Mikhailov, Victor, Hvinden, Ingvild, Walsby-Tickle, John, Liu, Xiao, Pettinati, Ilaria, Cadoux-Hudson, Tom, McCullagh, James S. O., Schofield, Christopher J.
Published in Communications biology (01.11.2021)
Published in Communications biology (01.11.2021)
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Journal Article
Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes
Chong, MuiPhin, Toh, LeeRoy, Tumber, Anthony, Chan, YanYing, Chan, MunChiang, Abboud, Martine I., Schofield, Christopher J., Yeoh, KarKheng
Published in Medicinal chemistry research (01.04.2021)
Published in Medicinal chemistry research (01.04.2021)
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Journal Article
Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease
Liu, Haotian, Xie, Yong, Wang, Xia, Abboud, Martine I., Ma, Chao, Ge, Wei, Schofield, Christopher J.
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Interaction of Avibactam with Class B Metallo-β-Lactamases
Abboud, Martine I, Damblon, Christian, Brem, Jürgen, Smargiasso, Nicolas, Mercuri, Paola, Gilbert, Bernard, Rydzik, Anna M, Claridge, Timothy D W, Schofield, Christopher J, Frère, Jean-Marie
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant
Herold, Ryan A, Reinbold, Raphael, Megarity, Clare F, Abboud, Martine I, Schofield, Christopher J, Armstrong, Fraser A
Published in The journal of physical chemistry letters (08.07.2021)
Published in The journal of physical chemistry letters (08.07.2021)
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Journal Article
Carcinogenic and neurotoxic risks of acrylamide consumed through bread, kaak, toast, and crackers among the Lebanese Population
El-Zakhem Naous, Ghada, Merhi, Areej, Daher, Ralph, Mroueh, Mohamad, Abboud, Martine I., Taleb, Robin I.
Published in Regulatory toxicology and pharmacology (01.07.2022)
Published in Regulatory toxicology and pharmacology (01.07.2022)
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Journal Article
In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors
Cain, Ricky, Brem, Jürgen, Zollman, David, McDonough, Michael A, Johnson, Rachel M, Spencer, James, Makena, Anne, Abboud, Martine I, Cahill, Samuel, Lee, Sook Y, McHugh, Peter J, Schofield, Christopher J, Fishwick, Colin W. G
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
NMR-filtered virtual screening leads to non-metal chelating metallo-beta-lactamase inhibitors
Li, Guo-Bo, Abboud, Martine I., Brem, Jurgen, Someya, Hidenori, Lohans, Christopher T., Yang, Sheng-Yong, Spencer, James, Wareham, David W., McDonough, Michael A., Schofield, Christopher J.
Published in Chemical science (Cambridge) (01.02.2017)
Published in Chemical science (Cambridge) (01.02.2017)
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