Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability: Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Group of α-Aminoacyl-l-cis-4,5-methanoprolinenitrile-Based Inhibitors
Magnin, David R, Robl, Jeffrey A, Sulsky, Richard B, Augeri, David J, Huang, Yanting, Simpkins, Ligaya M, Taunk, Prakash C, Betebenner, David A, Robertson, James G, Abboa-Offei, Benoni E, Wang, Aiying, Cap, Michael, Xin, Li, Tao, Li, Sitkoff, Doree F, Malley, Mary F, Gougoutas, Jack Z, Khanna, Ashish, Huang, Qi, Han, Song-Ping, Parker, Rex A, Hamann, Lawrence G
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Dual Metalloprotease Inhibitors: Mercaptoacetyl-Based Fused Heterocyclic Dipeptide Mimetics as Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase
Robl, Jeffrey A, Sun, Chong-Qing, Stevenson, Jay, Ryono, Denis E, Simpkins, Ligaya M, Cimarusti, Maria P, Dejneka, Tamara, Slusarchyk, William A, Chao, Sam, Stratton, Leslie, Misra, Raj N, Bednarz, Mark S, Asaad, Magdi M, Cheung, Hong Son, Abboa-Offei, Benoni E, Smith, Patricia L, Mathers, Parker D, Fox, Maxine, Schaeffer, Thomas R, Seymour, Andrea A, Trippodo, Nick C
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
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Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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Potentiation of natriuretic peptides by neutral endopeptidase inhibitors
Seymour, A A, Abboa-Offei, B E, Smith, P L, Mathers, P D, Asaad, M M, Rogers, W L
Published in Clinical and experimental pharmacology & physiology (01.01.1995)
Published in Clinical and experimental pharmacology & physiology (01.01.1995)
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Sodium loads enhance the natriuretic responses to atrial natriuretic peptide and neutral endopeptidase inhibitors in conscious cynomolgus monkeys
Seymour, A A, Asaad, M M, Abboa-Offei, B, Smith, P L, Rogers, W L
Published in Clinical and experimental pharmacology & physiology (01.11.1994)
Published in Clinical and experimental pharmacology & physiology (01.11.1994)
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Renal and depressor activities of inhibitors of neutral endopeptidase and angiotensin converting enzyme in monkeys infused with angiotensin II
Seymour, A A, Asaad, M M, Abboa-Offei, B E, Smith, P L, Mathers, P D, Rogers, W L, Dorso, C R
Published in Journal of cardiovascular pharmacology (01.11.1996)
Published in Journal of cardiovascular pharmacology (01.11.1996)
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Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Bisaha, Sharon, Spergel, Steve, Girotra, Ravi, Lee, Ving G, Lloyd, John, Misra, Raj N, Schmidt, Joan, Mathur, Arvind, Stratton, Leslie, Kelly, Yolanda F, Bird, Eileen, Waldron, Tom, Liu, Eddie C.-K, Zhang, Rongan, Lee, Helen, Serafino, Randy, Abboa-Offei, Benoni, Mathers, Parker, Giancarli, Mary, Seymour, Andrea Ann, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C, Hunt, John T
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Determinants of in vivo activity of neutral endopeptidase 3.4.24.11 and angiotensin converting enzyme inhibitors
Seymour, A A, Asaad, M M, Abboa-Offei, B E, Smith, P L, Rogers, W L, Dorso, C R
Published in The Journal of pharmacology and experimental therapeutics (01.02.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.02.1996)
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