Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds
Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E
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Published in Chemical research in toxicology (15.10.2012)
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CYTOCHROME P450 GENE INDUCTION IN RATS EX VIVO ASSESSED BY QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (TAQMAN)
BALDWIN, Sandra J, BRAMHALL, Jo L, ASHBY, Charlotte A, LIN YUE, MURDOCK, Paul R, HOOD, Steven R, AYRTON, Andrew D, CLARKE, Stephen E
Published in Drug metabolism and disposition (01.06.2006)
Published in Drug metabolism and disposition (01.06.2006)
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Biopharmaceutics Classification System: Validation and Learnings of an in Vitro Permeability Assay
Thiel-Demby, Victoria E, Humphreys, Joan E, St. John Williams, Lisa A, Ellens, Harma M, Shah, Nipa, Ayrton, Andrew D, Polli, Joseph W
Published in Molecular pharmaceutics (02.02.2009)
Published in Molecular pharmaceutics (02.02.2009)
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Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics
Groenendaal, Dorien, Freijer, Jan, Rosier, Andrea, de Mik, Dennis, Nicholls, Glynis, Hersey, Anne, Ayrton, Andrew D., Danhof, Meindert, de Lange, Elizabeth C.M.
Published in European journal of pharmaceutical sciences (03.07.2008)
Published in European journal of pharmaceutical sciences (03.07.2008)
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Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes
Clarke, Stephen E, Baldwin, Sandra J, Bloomer, Jacqueline C, Ayrton, Andrew D, Sozio, Randall S, Chenery, Richard J
Published in Chemical research in toxicology (01.11.1994)
Published in Chemical research in toxicology (01.11.1994)
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Expression, Purification, and Biochemical Characterization of A Human Cytochrome P450 CYP2D6-NADPH Cytochrome P450 Reductase Fusion Protein
Deeni, Yusuf Y., Paine, Mark J.I., Ayrton, Andrew D., Clarke, Stephen E., Chenery, Richard, Wolf, C.Roland
Published in Archives of biochemistry and biophysics (01.12.2001)
Published in Archives of biochemistry and biophysics (01.12.2001)
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8-piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines : Potent, selective, orally bioavailable 5-HT1 receptor ligands
HEIGHTMAN, Tom D, GASTER, Laramie M, GORDON, Laurie J, HOLLAND, Vicky A, POWLES, Jenifer, RILEY, Graham J, STEAN, Tania O, TRAIL, Brenda K, UPTON, Neil, AUSTIN, Nigel E, AYRTON, Andrew D, COLEMAN, Tanya, PARDOE, Sarah L, CUTLER, Leanne, PILLEUX, Jean-Pierre, HADLEY, Michael S, MIDDLEMISS, Derek N, PRICE, Gary W, ROBERTS, Claire, SCOTT, Claire M, WATSON, Jeannette M
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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8-Piperazinyl-2,3-dihydropyrrolo[3,2- g]isoquinolines: Potent, selective, orally bioavailable 5-HT 1 receptor ligands
Heightman, Tom D., Gaster, Laramie M., Pardoe, Sarah L., Pilleux, Jean-Pierre, Hadley, Michael S., Middlemiss, Derek N., Price, Gary W., Roberts, Claire, Scott, Claire M., Watson, Jeannette M., Gordon, Laurie J., Holland, Vicky A., Powles, Jenifer, Riley, Graham J., Stean, Tania O., Trail, Brenda K., Upton, Neil, Austin, Nigel E., Ayrton, Andrew D., Coleman, Tanya, Cutler, Leanne
Published in Bioorganic & medicinal chemistry letters (2005)
Published in Bioorganic & medicinal chemistry letters (2005)
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Preferential induction of the rat hepatic P 450 I proteins by the food carcinogen 2‐amino‐3‐methyl‐imidazo[4,5‐ f ]quinoline
RODRIGUES, A. David, AYRTON, Andrew D., WILLIAMS, Elisabeth J., LEWIS, David F. V., WALKER, Ronald, IOANNIDES, Costas
Published in European journal of biochemistry (15.05.1989)
Published in European journal of biochemistry (15.05.1989)
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Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity
Ayrton, Andrew D., Lewis, David F.V., Ioannides, Costas, Walker, Ronald
Published in Biochimica et biophysica acta (18.12.1987)
Published in Biochimica et biophysica acta (18.12.1987)
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Preferential induction of the rat hepatic P450 I proteins by the food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline
Rodrigues, A.D. (University of Surrey, Guildford), Ayrton, A.D, Williams, E.J, Lewis, D.F.V, Walker, R, Ioannides, C
Published in European journal of biochemistry (15.05.1989)
Published in European journal of biochemistry (15.05.1989)
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Feprazone: an inducer of the P450 II B family of proteins in the rat
Smith, J N, Ayrton, A D, Chown, J, Lewis, D F, Ioannides, C
Published in Journal of biochemical toxicology (1990)
Published in Journal of biochemical toxicology (1990)
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