Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice
Sacino, Amanda N., Brooks, Mieu, Thomas, Michael A., McKinney, Alex B., Lee, Sooyeon, Regenhardt, Robert W., McGarvey, Nicholas H., Ayers, Jacob I., Notterpek, Lucia, Borchelt, David R., Golde, Todd E., Giasson, Benoit I.
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2014)
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Journal Article
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J, Galaleldeen, Ahmad, Cashman, Neil R, Borchelt, David R, Ayers, Jacob I
Published in PloS one (30.01.2020)
Published in PloS one (30.01.2020)
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Journal Article
Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts
Ayers, Jacob I, Riffe, Cara J, Sorrentino, Zachary A, Diamond, Jeffrey, Fagerli, Eric, Brooks, Mieu, Galaleldeen, Ahmad, Hart, P John, Giasson, Benoit I
Published in Journal of virology (15.09.2018)
Published in Journal of virology (15.09.2018)
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Journal Article
Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice
Ayers, Jacob I, Xu, Guilian, Lu, Qing, Dillon, Kristy, Fromholt, Susan, Borchelt, David R
Published in Viruses (26.08.2023)
Published in Viruses (26.08.2023)
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Journal Article
Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS
Ayers, Jacob I., Diamond, Jeffrey, Sari, Adriana, Fromholt, Susan, Galaleldeen, Ahmad, Ostrow, Lyle W., Glass, Jonathan D., Hart, P. John, Borchelt, David R.
Published in Acta neuropathologica (01.12.2016)
Published in Acta neuropathologica (01.12.2016)
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Journal Article
The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease
Ayers, Jacob I, Schutt, Charles R, Shikiya, Ronald A, Aguzzi, Adriano, Kincaid, Anthony E, Bartz, Jason C
Published in PLoS pathogens (17.03.2011)
Published in PLoS pathogens (17.03.2011)
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Journal Article
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease
Ayers, Jacob I, Schutt, Charles R, Shikiya, Ronald A, Aguzzi, Adriano, Kincaid, Anthony E, Bartz, Jason C
Published in PLoS pathogens (01.03.2011)
Published in PLoS pathogens (01.03.2011)
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Journal Article
Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models
Crosby, Keith, Crown, Anthony M, Roberts, Brittany L, Brown, Hilda, Ayers, Jacob I, Borchelt, David R
Published in PloS one (06.11.2018)
Published in PloS one (06.11.2018)
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Journal Article
Coinfecting Prion Strains Compete for a Limiting Cellular Resource
Shikiya, Ronald A, Ayers, Jacob I, Schutt, Charles R, Kincaid, Anthony E, Bartz, Jason C
Published in Journal of Virology (01.06.2010)
Published in Journal of Virology (01.06.2010)
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Journal Article
Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
Ayers, Jacob I, Xu, Guilian, Dillon, Kristy, Lu, Qing, Chen, Zhijuan, Beckman, John, Moreno-Romero, Alma K, Zamora, Diana L, Galaleldeen, Ahmad, Borchelt, David R
Published in Acta neuropathologica communications (20.05.2021)
Published in Acta neuropathologica communications (20.05.2021)
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Journal Article
Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis
Crown, Anthony M, Roberts, Brittany L, Crosby, Keith, Brown, Hilda, Ayers, Jacob I, Hart, P John, Borchelt, David R
Published in G3 : genes - genomes - genetics (01.03.2019)
Published in G3 : genes - genomes - genetics (01.03.2019)
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Journal Article
ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons
Osking, Zachary, Ayers, Jacob I., Hildebrandt, Ryan, Skruber, Kristen, Brown, Hilda, Ryu, Daniel, Eukovich, Amanda R., Golde, Todd E., Borchelt, David R., Read, Tracy-Ann, Vitriol, Eric A.
Published in iScience (25.01.2019)
Published in iScience (25.01.2019)
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Journal Article
Prion-like Spreading in Tauopathies
Ayers, Jacob I, Giasson, Benoit I, Borchelt, David R
Published in Biological psychiatry (1969) (15.02.2018)
Published in Biological psychiatry (1969) (15.02.2018)
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Journal Article
ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons
Osking, Zachary, Ayers, Jacob I., Hildebrandt, Ryan, Skruber, Kristen, Brown, Hilda, Ryu, Daniel, Eukovich, Amanda R., Golde, Todd E., Borchelt, David R., Read, Tracy-Ann, Vitriol, Eric A.
Published in iScience (27.09.2019)
Published in iScience (27.09.2019)
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Journal Article
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy
Ayers, Jacob I, Lee, Joanne, Monteiro, Octovia, Woerman, Amanda L, Lazar, Ann A, Condello, Carlo, Paras, Nick A, Prusiner, Stanley B
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (08.02.2022)
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Journal Article
Prion Interference Is Due to a Reduction in Strain-Specific PrPSc Levels
BARTZ, Jason C, KRAMER, Michelle L, SHEEHAN, Meghan H, HUTTER, Jessica A. L, AYERS, Jacob I, BESSEN, Richard A, KINCAID, Anthony E
Published in Journal of Virology (01.01.2007)
Published in Journal of Virology (01.01.2007)
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