Progress towards a public chemogenomic set for protein kinases and a call for contributions
Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M
Published in PloS one (02.08.2017)
Published in PloS one (02.08.2017)
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Journal Article
CDK16: the pick of the understudied PCTAIRE kinases
Axtman, Alison, Drewry, David, Wells, Carrow
Published in Nature reviews. Drug discovery (01.07.2019)
Published in Nature reviews. Drug discovery (01.07.2019)
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Journal Article
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
Wells, Carrow I., Drewry, David H., Pickett, Julie E., Tjaden, Amelie, Krämer, Andreas, Müller, Susanne, Gyenis, Laszlo, Menyhart, Daniel, Litchfield, David W., Knapp, Stefan, Axtman, Alison D.
Published in Cell chemical biology (15.04.2021)
Published in Cell chemical biology (15.04.2021)
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Journal Article
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
Bashore, Frances M., Marquez, Ariana B., Chaikuad, Apirat, Howell, Stefanie, Dunn, Andrea S., Beltran, Alvaro A., Smith, Jeffery L., Drewry, David H., Beltran, Adriana S., Axtman, Alison D.
Published in Scientific reports (14.04.2023)
Published in Scientific reports (14.04.2023)
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Journal Article
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration
Drewry, David H., Annor-Gyamfi, Joel K., Wells, Carrow, Pickett, Julie E., Dederer, Verena, Preuss, Franziska, Mathea, Sebastian, Axtman, Alison D.
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Journal Article
Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Mircroglial Model
Mishra, Swati, Kinoshita, Chizuru, Axtman, Alison D, Young, Jessica E
Published in Frontiers in molecular neuroscience (14.06.2022)
Published in Frontiers in molecular neuroscience (14.06.2022)
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Journal Article
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1
Jamieson, Sam A, Ruan, Zheng, Burgess, Abigail E, Curry, Jack R, McMillan, Hamish D, Brewster, Jodi L, Dunbier, Anita K, Axtman, Alison D, Kannan, Natarajan, Mace, Peter D
Published in Science signaling (25.09.2018)
Published in Science signaling (25.09.2018)
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Journal Article
Fused Tetrahydroquinolines Are Interfering with Your Assay
Bashore, Frances M., Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G., Frye, Stephen V., Pearce, Kenneth H., Fu, Haian, Willson, Timothy M., Drewry, David H., Axtman, Alison D.
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Journal Article
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
Agajanian, Megan J., Walker, Matthew P., Axtman, Alison D., Ruela-de-Sousa, Roberta R., Serafin, D. Stephen, Rabinowitz, Alex D., Graham, David M., Ryan, Meagan B., Tamir, Tigist, Nakamichi, Yuko, Gammons, Melissa V., Bennett, James M., Couñago, Rafael M., Drewry, David H., Elkins, Jonathan M., Gileadi, Carina, Gileadi, Opher, Godoi, Paulo H., Kapadia, Nirav, Müller, Susanne, Santiago, André S., Sorrell, Fiona J., Wells, Carrow I., Fedorov, Oleg, Willson, Timothy M., Zuercher, William J., Major, Michael B.
Published in Cell reports (Cambridge) (02.01.2019)
Published in Cell reports (Cambridge) (02.01.2019)
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Journal Article
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
Wells, Carrow I, Al-Ali, Hassan, Andrews, David M, Asquith, Christopher R M, Axtman, Alison D, Dikic, Ivan, Ebner, Daniel, Ettmayer, Peter, Fischer, Christian, Frederiksen, Mathias, Futrell, Robert E, Gray, Nathanael S, Hatch, Stephanie B, Knapp, Stefan, Lücking, Ulrich, Michaelides, Michael, Mills, Caitlin E, Müller, Susanne, Owen, Dafydd, Picado, Alfredo, Saikatendu, Kumar S, Schröder, Martin, Stolz, Alexandra, Tellechea, Mariana, Turunen, Brandon J, Vilar, Santiago, Wang, Jinhua, Zuercher, William J, Willson, Timothy M, Drewry, David H
Published in International journal of molecular sciences (08.01.2021)
Published in International journal of molecular sciences (08.01.2021)
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Journal Article
Illuminating function of the understudied druggable kinome
Gomez, Shawn M., Axtman, Alison D., Willson, Timothy M., Major, Michael B., Townsend, Reid R., Sorger, Peter K., Johnson, Gary L.
Published in Drug discovery today (01.03.2024)
Published in Drug discovery today (01.03.2024)
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Journal Article
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
Asquith, Christopher R.M., East, Michael P., Laitinen, Tuomo, Alamillo-Ferrer, Carla, Hartikainen, Erkka, Wells, Carrow I., Axtman, Alison D., Drewry, David H., Tizzard, Graham J., Poso, Antti, Willson, Timothy M., Johnson, Gary L.
Published in European journal of medicinal chemistry (05.05.2024)
Published in European journal of medicinal chemistry (05.05.2024)
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM
Bashore, Frances M, Katis, Vittorio L, Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J, Rygiel, Karolina A, Leisner, Tina M, Chalk, Rod, Mishra, Swati, Williams, C Andrew, Gileadi, Opher, Brennan, Paul E, Wiley, Jesse C, Gockley, Jake, Cary, Gregory A, Carter, Gregory W, Young, Jessica E, Pearce, Kenneth H, Fu, Haian, Axtman, Alison D
Published in PloS one (15.02.2024)
Published in PloS one (15.02.2024)
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Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
Ong, Han Wee, Yang, Xuan, Smith, Jeffery L, Taft-Benz, Sharon, Howell, Stefanie, Dickmander, Rebekah J, Havener, Tammy M, Sanders, Marcia K, Brown, Jason W, Couñago, Rafael M, Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J, Heise, Mark, Axtman, Alison D, Drewry, David H, Willson, Timothy M
Published in Molecules (Basel, Switzerland) (02.09.2024)
Published in Molecules (Basel, Switzerland) (02.09.2024)
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Journal Article
Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling
Agajanian, Megan J., Potjewyd, Frances M., Bowman, Brittany M., Solomon, Smaranda, LaPak, Kyle M., Bhatt, Dhaval P., Smith, Jeffery L., Goldfarb, Dennis, Axtman, Alison D., Major, Michael B.
Published in The Journal of biological chemistry (01.06.2022)
Published in The Journal of biological chemistry (01.06.2022)
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Journal Article
Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model
Mishra, Swati, Kinoshita, Chizuru, Axtman, Alison D, Young, Jessica E
Published in Frontiers in molecular neuroscience (2022)
Published in Frontiers in molecular neuroscience (2022)
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