Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat
Stemp, Geoffrey, Ashmeade, Tracey, Branch, Clive L, Hadley, Michael S, Hunter, A. Jacqueline, Johnson, Christopher N, Nash, David J, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Avenell, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Routledge, Carole, Wood, Martyn
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
Get full text
Journal Article
Evidence for antagonist activity of the dopamine D3 receptor partial agonist, BP 897, at human dopamine D3 receptor
Wood, Martyn D, Boyfield, Izzy, Nash, David J, Jewitt, Frances R, Avenell, Kim Y, Riley, Graham J
Published in European journal of pharmacology (27.10.2000)
Published in European journal of pharmacology (27.10.2000)
Get full text
Journal Article
Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor
AUSTIN, Nigel E, AVENELL, Kim Y, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, WOOD, Martyn D, BOYFIELD, Izzy, BRANCH, Clive L, HADLEY, Michael S, JEFFREY, Phillip, JOHNSON, Christopher N, MACDONALD, Gregor J, NASH, David J, RILEY, Graham J
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Get full text
Journal Article
Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor
AUSTIN, Nigel E, AVENELL, Kim Y, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, WOOD, Martyn, BOYFIELD, Izzy, BRANCH, Clive L, HADLEY, Michael S, JEFFREY, Phillip, JOHNSON, Christopher N, MACDONALD, Gregor J, NASH, David J, RILEY, Graham J
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Get full text
Journal Article
Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A
Charlie Reavill, Stephen G. Taylor, Martyn D. Wood, Tracey Ashmeade, Nigel E. Austin, Kim Y. Avenell, Izzy Boyfield, Clive L. Branch, Jackie Cilia, Martyn C. Coldwell, Michael S. Hadley, A. Jackie Hunter, Phil Jeffrey, Frances Jewitt, Christopher N. Johnson, Declan N. C. Jones, Andrew D. Medhurst, Derek N. Middlemiss, David J. Nash, Graham J. Riley, Carol Routledge, Geoff Stemp, Kevin M. Thewlis, Brenda Trail, Antonio K. K. Vong, Jim J. Hagan
Published in The Journal of pharmacology and experimental therapeutics (01.09.2000)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.09.2000)
Journal Article
Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D-3 receptor antagonist with high oral bioavailability and CNS penetration in the rat
Stemp, G, Ashmeade, T, Branch, CL, Hadley, MS, Hunter, AJ, Johnson, CN, Nash, DJ, Thewlis, KM, Vong, AKK, Austin, NE, Jeffrey, P, Avenell, KY, Boyfield, Hagan, JJ, Middlemiss, DN, Reavill, C, Riley, GJ, Routledge, C, Wood, M
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
Get full text
Journal Article
Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D 3 receptor
Avenell, Kim Y, Boyfield, Izzy, Hadley, Michael S, Johnson, Christopher N, Nash, David J, Riley, Graham J, Stemp, Geoffrey
Published in Bioorganic & medicinal chemistry letters (20.09.1999)
Published in Bioorganic & medicinal chemistry letters (20.09.1999)
Get full text
Journal Article
Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor
Austin, N E, Avenell, K Y, Boyfield, I, Branch, C L, Coldwell, M C, Hadley, M S, Jeffrey, P, Johns, A, Johnson, C N, Nash, D J, Riley, G J, Smith, S A, Stacey, R C, Stemp, G, Thewlis, K M, Vong, A K
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Get full text
Journal Article
Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D 3 receptor
Austin, Nigel E., Avenell, Kim Y., Boyfield, Izzy, Branch, Clive L., Coldwell, Martyn C., Hadley, Michael S., Jeffrey, Phillip, Johns, Amana, Johnson, Christopher N., Nash, David J., Riley, Graham J., Smith, Stephen A., Stacey, Rachel C., Stemp, Geoffrey, Thewlis, Kevin M., Vong, Antonio K.K.
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Get full text
Journal Article
Novel 2,3,4,5-tetrahydro-1 H-3-benzazepines with high affinity and selectivity for the dopamine D 3 receptor
Austin, Nigel E, Avenell, Kim Y, Boyfield, Izzy, Branch, Clive L, Hadley, Michael S, Jeffrey, Phillip, Johnson, Christopher N, Macdonald, Gregor J, Nash, David J, Riley, Graham J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K.K, Wood, Martyn
Published in Bioorganic & medicinal chemistry letters (2000)
Published in Bioorganic & medicinal chemistry letters (2000)
Get full text
Journal Article
Design and synthesis of novel 2,3-dihydro-1 H-isoindoles with high affinity and selectivity for the dopamine D 3 receptor
Austin, Nigel E, Avenell, Kim Y, Boyfield, Izzy, Branch, Clive L, Hadley, Michael S, Jeffrey, Phillip, Johnson, Christopher N, Macdonald, Gregor J, Nash, David J, Riley, Graham J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K.K, Wood, Martyn D
Published in Bioorganic & medicinal chemistry letters (2001)
Published in Bioorganic & medicinal chemistry letters (2001)
Get full text
Journal Article
Fused aminotetralins: novel antagonists with high selectivity for the dopamine D 3 receptor
Avenell, Kim Y., Boyfield, Izzy, Coldwell, Martyn C., Hadley, Michael S., Healy, Maureen A.M., Jeffrey, Philip M., Johnson, Christopher N., Nash, David J., Riley, Graham J., Scott, Emma E., Smith, Stephen A., Stacey, Rachel, Stemp, Geoffrey, Thewlis, Kevin M.
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Get full text
Journal Article
Fused aminotetralins : Novel antagonists with high selectivity for the dopamine D3 receptor
AVENELL, K. Y, BOYFIELD, I, SMITH, S. A, STACEY, R, STEMP, G, THEWLIS, K. M, COLDWELL, M. C, HADLEY, M. S, HEALY, M. A. M, JEFFREY, P. M, JOHNSON, C. N, NASH, D. J, RILEY, G. J, SCOTT, E. E
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Get full text
Journal Article