Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague–Dawley rats: A locomotor activity and gene induction study
Kalinichev, Mikhail, Robbins, Melanie J., Hartfield, Elizabeth M., Maycox, Peter R., Moore, Susan H., Savage, Kevin M., Austin, Nigel E., Jones, Declan N.C.
Published in Progress in neuro-psychopharmacology & biological psychiatry (15.02.2008)
Published in Progress in neuro-psychopharmacology & biological psychiatry (15.02.2008)
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Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist
Macdonald, Gregor J, Branch, Clive L, Hadley, Michael S, Johnson, Christopher N, Nash, David J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Winborn, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Watson, Jeannette M, Wood, Martyn, Parker, Steve G, Ashby, Charles R
Published in Journal of medicinal chemistry (06.11.2003)
Published in Journal of medicinal chemistry (06.11.2003)
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Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators
Ward, Simon E, Harries, Mark, Aldegheri, Laura, Austin, Nigel E, Ballantine, Stuart, Ballini, Elisa, Bradley, Daniel M, Bax, Benjamin D, Clarke, Brian P, Harris, Andrew J, Harrison, Stephen A, Melarange, Rosemary A, Mookherjee, Claudette, Mosley, Julie, Dal Negro, Gianni, Oliosi, Beatrice, Smith, Kathrine J, Thewlis, Kevin M, Woollard, Patrick M, Yusaf, Shahnaz P
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology
Schneider, Eric L., Ashley, Gary W., Dillen, Lieve, Stoops, Bart, Austin, Nigel E., Malcolm, Bruce A., Santi, Daniel V.
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2015)
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2015)
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The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat
Large, Charles H, Kalinichev, Mikhail, Lucas, Adam, Carignani, Corrado, Bradford, Andrea, Garbati, Nicoletta, Sartori, Ilaria, Austin, Nigel E, Ruffo, Alberto, Jones, Declan N.C, Alvaro, Giuseppe, Read, Kevin D
Published in Epilepsy research (01.07.2009)
Published in Epilepsy research (01.07.2009)
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Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1‐receptor antagonist in the rat
Kalinichev, Mikhail, Bradford, Andrea, Bison, Silvia, Lucas, Adam, Sartori, Ilaria, Garbati, Nicoletta, Andreetta, Filippo, Bate, Simon, Austin, Nigel E., Jones, Declan N. C., Read, Kevin D., Alvaro, Giuseppe, Large, Charles H.
Published in Epilepsia (Copenhagen) (01.08.2010)
Published in Epilepsia (Copenhagen) (01.08.2010)
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Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat
Stemp, Geoffrey, Ashmeade, Tracey, Branch, Clive L, Hadley, Michael S, Hunter, A. Jacqueline, Johnson, Christopher N, Nash, David J, Thewlis, Kevin M, Vong, Antonio K. K, Austin, Nigel E, Jeffrey, Phillip, Avenell, Kim Y, Boyfield, Izzy, Hagan, Jim J, Middlemiss, Derek N, Reavill, Charlie, Riley, Graham J, Routledge, Carole, Wood, Martyn
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
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The design of 8,8-Dimethyl[1,6]naphthyridines as potential anticonvulsant agents
Austin, Nigel E, Hadley, Michael S, Harling, John D, Harrington, Frank P, Macdonald, Gregor J, Mitchell, Darren J, Riley, Graham J, Stean, Tania O, Stemp, Geoffrey, Stratton, Sharon C, Thompson, Mervyn, Upton, Neil
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
Published in Bioorganic & medicinal chemistry letters (19.05.2003)
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8-piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines : Potent, selective, orally bioavailable 5-HT1 receptor ligands
HEIGHTMAN, Tom D, GASTER, Laramie M, GORDON, Laurie J, HOLLAND, Vicky A, POWLES, Jenifer, RILEY, Graham J, STEAN, Tania O, TRAIL, Brenda K, UPTON, Neil, AUSTIN, Nigel E, AYRTON, Andrew D, COLEMAN, Tanya, PARDOE, Sarah L, CUTLER, Leanne, PILLEUX, Jean-Pierre, HADLEY, Michael S, MIDDLEMISS, Derek N, PRICE, Gary W, ROBERTS, Claire, SCOTT, Claire M, WATSON, Jeannette M
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor
AUSTIN, Nigel E, AVENELL, Kim Y, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, WOOD, Martyn D, BOYFIELD, Izzy, BRANCH, Clive L, HADLEY, Michael S, JEFFREY, Phillip, JOHNSON, Christopher N, MACDONALD, Gregor J, NASH, David J, RILEY, Graham J
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor
AUSTIN, Nigel E, AVENELL, Kim Y, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, WOOD, Martyn, BOYFIELD, Izzy, BRANCH, Clive L, HADLEY, Michael S, JEFFREY, Phillip, JOHNSON, Christopher N, MACDONALD, Gregor J, NASH, David J, RILEY, Graham J
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
Published in Bioorganic & medicinal chemistry letters (20.11.2000)
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Journal Article
Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A
Charlie Reavill, Stephen G. Taylor, Martyn D. Wood, Tracey Ashmeade, Nigel E. Austin, Kim Y. Avenell, Izzy Boyfield, Clive L. Branch, Jackie Cilia, Martyn C. Coldwell, Michael S. Hadley, A. Jackie Hunter, Phil Jeffrey, Frances Jewitt, Christopher N. Johnson, Declan N. C. Jones, Andrew D. Medhurst, Derek N. Middlemiss, David J. Nash, Graham J. Riley, Carol Routledge, Geoff Stemp, Kevin M. Thewlis, Brenda Trail, Antonio K. K. Vong, Jim J. Hagan
Published in The Journal of pharmacology and experimental therapeutics (01.09.2000)
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Published in The Journal of pharmacology and experimental therapeutics (01.09.2000)
Journal Article
Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NKI -receptor antagonist in the rat
KALINICHEV, Mikhail, BRADFORD, Andrea, READ, Kevin D, ALVARO, Giuseppe, LARGE, Charles H, BISON, Silvia, LUCAS, Adam, SARTORI, Ilaria, GARBATI, Nicoletta, ANDREETTA, Filippo, BATE, Simon, AUSTIN, Nigel E, JONES, Declan N. C
Published in Epilepsia (Copenhagen) (2010)
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Published in Epilepsia (Copenhagen) (2010)
Journal Article
Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D-3 receptor antagonist with high oral bioavailability and CNS penetration in the rat
Stemp, G, Ashmeade, T, Branch, CL, Hadley, MS, Hunter, AJ, Johnson, CN, Nash, DJ, Thewlis, KM, Vong, AKK, Austin, NE, Jeffrey, P, Avenell, KY, Boyfield, Hagan, JJ, Middlemiss, DN, Reavill, C, Riley, GJ, Routledge, C, Wood, M
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
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Journal Article
8-Piperazinyl-2,3-dihydropyrrolo[3,2- g]isoquinolines: Potent, selective, orally bioavailable 5-HT 1 receptor ligands
Heightman, Tom D., Gaster, Laramie M., Pardoe, Sarah L., Pilleux, Jean-Pierre, Hadley, Michael S., Middlemiss, Derek N., Price, Gary W., Roberts, Claire, Scott, Claire M., Watson, Jeannette M., Gordon, Laurie J., Holland, Vicky A., Powles, Jenifer, Riley, Graham J., Stean, Tania O., Trail, Brenda K., Upton, Neil, Austin, Nigel E., Ayrton, Andrew D., Coleman, Tanya, Cutler, Leanne
Published in Bioorganic & medicinal chemistry letters (2005)
Published in Bioorganic & medicinal chemistry letters (2005)
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Journal Article
Design and Synthesis of trans -3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1 H -3-benzazepine (SB-414796): A Potent and Selective Dopamine D 3 Receptor Antagonist
Macdonald, Gregor J., Branch, Clive L., Hadley, Michael S., Johnson, Christopher N., Nash, David J., Smith, Alexander B., Stemp, Geoffrey, Thewlis, Kevin M., Vong, Antonio K. K., Austin, Nigel E., Jeffrey, Phillip, Winborn, Kim Y., Boyfield, Izzy, Hagan, Jim J., Middlemiss, Derek N., Reavill, Charlie, Riley, Graham J., Watson, Jeannette M., Wood, Martyn, Parker, Steve G., Ashby, Charles R.
Published in Journal of medicinal chemistry (01.11.2003)
Published in Journal of medicinal chemistry (01.11.2003)
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Journal Article
Design and synthesis of trans-3-2-4-3-(3-(5-methyl-1,2,4-oxadiazolyl))-phenylcarboxamidocyclohexyl ethyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): A potent and selective dopamine D3 receptor antagonist
MACDONALD, Gregor J, BRANCH, Clive L, JEFFREY, Phillip, WINBORN, Kim Y, BOYFIELD, Izzy, HAGAN, Jim J, MIDDLEMISS, Derek N, REAVILL, Charlie, RILEY, Graham J, WATSON, Jeannette M, WOOD, Martyn, PARKER, Steve G, HADLEY, Michael S, ASHBY, Charles R, JOHNSON, Christopher N, NASH, David J, SMITH, Alexander B, STEMP, Geoffrey, THEWLIS, Kevin M, VONG, Antonio K. K, AUSTIN, Nigel E
Published in Journal of medicinal chemistry (2003)
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Published in Journal of medicinal chemistry (2003)
Journal Article
Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D 3 receptor
Austin, Nigel E., Avenell, Kim Y., Boyfield, Izzy, Branch, Clive L., Coldwell, Martyn C., Hadley, Michael S., Jeffrey, Phillip, Johns, Amana, Johnson, Christopher N., Nash, David J., Riley, Graham J., Smith, Stephen A., Stacey, Rachel C., Stemp, Geoffrey, Thewlis, Kevin M., Vong, Antonio K.K.
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
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Journal Article
Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor
Austin, N E, Avenell, K Y, Boyfield, I, Branch, C L, Coldwell, M C, Hadley, M S, Jeffrey, P, Johns, A, Johnson, C N, Nash, D J, Riley, G J, Smith, S A, Stacey, R C, Stemp, G, Thewlis, K M, Vong, A K
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
Published in Bioorganic & medicinal chemistry letters (18.01.1999)
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Journal Article
Novel 2,3,4,5-tetrahydro-1 H-3-benzazepines with high affinity and selectivity for the dopamine D 3 receptor
Austin, Nigel E, Avenell, Kim Y, Boyfield, Izzy, Branch, Clive L, Hadley, Michael S, Jeffrey, Phillip, Johnson, Christopher N, Macdonald, Gregor J, Nash, David J, Riley, Graham J, Smith, Alexander B, Stemp, Geoffrey, Thewlis, Kevin M, Vong, Antonio K.K, Wood, Martyn
Published in Bioorganic & medicinal chemistry letters (2000)
Published in Bioorganic & medicinal chemistry letters (2000)
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