Improving the human hazard characterization of chemicals: a Tox21 update
Tice, Raymond R, Austin, Christopher P, Kavlock, Robert J, Bucher, John R
Published in Environmental health perspectives (01.07.2013)
Published in Environmental health perspectives (01.07.2013)
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Journal Article
Therapies for rare diseases: therapeutic modalities, progress and challenges ahead
Tambuyzer, Erik, Vandendriessche, Benjamin, Austin, Christopher P, Brooks, Philip J, Larsson, Kristina, Miller Needleman, Katherine I, Valentine, James, Davies, Kay, Groft, Stephen C, Preti, Robert, Oprea, Tudor I, Prunotto, Marco
Published in Nature reviews. Drug discovery (01.02.2020)
Published in Nature reviews. Drug discovery (01.02.2020)
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Journal Article
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization
Huang, Ruili, Xia, Menghang, Sakamuru, Srilatha, Zhao, Jinghua, Shahane, Sampada A, Attene-Ramos, Matias, Zhao, Tongan, Austin, Christopher P, Simeonov, Anton
Published in Nature communications (26.01.2016)
Published in Nature communications (26.01.2016)
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The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics
Huang, Ruili, Grishagin, Ivan, Wang, Yuhong, Zhao, Tongan, Greene, Jon, Obenauer, John C, Ngan, Deborah, Nguyen, Dac-Trung, Guha, Rajarshi, Jadhav, Ajit, Southall, Noel, Simeonov, Anton, Austin, Christopher P
Published in Frontiers in pharmacology (26.04.2019)
Published in Frontiers in pharmacology (26.04.2019)
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Journal Article
Bisphenol A affects androgen receptor function via multiple mechanisms
Teng, Christina, Goodwin, Bonnie, Shockley, Keith, Xia, Menghang, Huang, Ruili, Norris, John, Merrick, B. Alex, Jetten, Anton M., Austin, Christopher P., Tice, Raymond R.
Published in Chemico-biological interactions (25.05.2013)
Published in Chemico-biological interactions (25.05.2013)
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The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality
Attene-Ramos, Matias S., Miller, Nicole, Huang, Ruili, Michael, Sam, Itkin, Misha, Kavlock, Robert J., Austin, Christopher P., Shinn, Paul, Simeonov, Anton, Tice, Raymond R., Xia, Menghang
Published in Drug discovery today (01.08.2013)
Published in Drug discovery today (01.08.2013)
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A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells
Chen, Yu, Tristan, Carlos A, Chen, Lu, Jovanovic, Vukasin M, Malley, Claire, Chu, Pei-Hsuan, Ryu, Seungmi, Deng, Tao, Ormanoglu, Pinar, Tao, Dingyin, Fang, Yuhong, Slamecka, Jaroslav, Hong, Hyenjong, LeClair, Christopher A, Michael, Sam, Austin, Christopher P, Simeonov, Anton, Singeç, Ilyas
Published in Nature methods (01.05.2021)
Published in Nature methods (01.05.2021)
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Journal Article
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
FISKUS, Warren, SABA, Nakhle, AUSTIN, Christopher P, MADDOCKS, Kami, BYRD, John, MELNICK, Ari, PENG HUANG, WIESTNER, Adrian, BHALLA, Kapil N, MIN SHEN, GHIAS, Mondana, JINYUN LIU, DAS GUPTA, Soumyasri, CHAUHAN, Lata, RAO, Rekha, GUNEWARDENA, Sumedha, SCHORNO, Kevin
Published in Cancer research (Chicago, Ill.) (01.05.2014)
Published in Cancer research (Chicago, Ill.) (01.05.2014)
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Journal Article
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
Huang, Ruili, Southall, Noel, Wang, Yuhong, Yasgar, Adam, Shinn, Paul, Jadhav, Ajit, Nguyen, Dac-Trung, Austin, Christopher P
Published in Science translational medicine (27.04.2011)
Published in Science translational medicine (27.04.2011)
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Journal Article
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells
Griner, Lesley A. Mathews, Guha, Rajarshi, Shinn, Paul, Young, Ryan M., Keller, Jonathan M., Liu, Dongbo, Goldlust, Ian S., Yasgar, Adam, McKnight, Crystal, Boxer, Matthew B., Duveau, Damien Y., Jiang, Jian-Kang, Michael, Sam, Mierzwa, Tim, Huang, Wenwei, Walsh, Martin J., Mott, Bryan T., Patel, Paresma, Leister, William, Maloney, David J., Leclair, Christopher A., Rai, Ganesha, Jadhav, Ajit, Peyser, Brian D., Austin, Christopher P., Martin, Scott E., Simeonov, Anton, Ferrer, Marc, Staudt, Louis M., Thomas, Craig J.
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (11.02.2014)
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Journal Article
Quantitative High-Throughput Screening: A Titration-Based Approach That Efficiently Identifies Biological Activities in Large Chemical Libraries
Inglese, James, Auld, Douglas S., Jadhav, Ajit, Johnson, Ronald L., Simeonov, Anton, Yasgar, Adam, Zheng, Wei, Austin, Christopher P.
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.2006)
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Journal Article
High-throughput screening assays for the identification of chemical probes
Inglese, James, Johnson, Ronald L, Simeonov, Anton, Xia, Menghang, Zheng, Wei, Austin, Christopher P, Auld, Douglas S
Published in Nature chemical biology (01.08.2007)
Published in Nature chemical biology (01.08.2007)
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Journal Article
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
Huang, Ruili, Sakamuru, Srilatha, Martin, Matt T, Reif, David M, Judson, Richard S, Houck, Keith A, Casey, Warren, Hsieh, Jui-Hua, Shockley, Keith R, Ceger, Patricia, Fostel, Jennifer, Witt, Kristine L, Tong, Weida, Rotroff, Daniel M, Zhao, Tongan, Shinn, Paul, Simeonov, Anton, Dix, David J, Austin, Christopher P, Kavlock, Robert J, Tice, Raymond R, Xia, Menghang
Published in Scientific reports (11.07.2014)
Published in Scientific reports (11.07.2014)
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Journal Article
Future of Rare Diseases Research 2017–2027: An IRDiRC Perspective
Austin, Christopher P., Cutillo, Christine M., Lau, Lilian P.L., Jonker, Anneliene H., Rath, Ana, Julkowska, Daria, Thomson, David, Terry, Sharon F., Montleau, Béatrice, Ardigò, Diego, Hivert, Virginie, Boycott, Kym M., Baynam, Gareth, Kaufmann, Petra, Taruscio, Domenica, Lochmüller, Hanns, Suematsu, Makoto, Incerti, Carlo, Draghia‐Akli, Ruxandra, Norstedt, Irene, Wang, Lu, Dawkins, Hugh J.S.
Published in Clinical and translational science (01.01.2018)
Published in Clinical and translational science (01.01.2018)
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Journal Article
Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors
Huang, Ruili, Xia, Menghang, Cho, Ming-Hsuang, Sakamuru, Srilatha, Shinn, Paul, Houck, Keith A., Dix, David J., Judson, Richard S., Witt, Kristine L., Kaylock, Robert J., Tice, Raymond R., Austin, Christopher P.
Published in Environmental health perspectives (01.08.2011)
Published in Environmental health perspectives (01.08.2011)
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Journal Article
The International Rare Diseases Research Consortium: Policies and Guidelines to maximize impact
Lochmüller, Hanns, Torrent I Farnell, Josep, Le Cam, Yann, Jonker, Anneliene H, Lau, Lilian Pl, Baynam, Gareth, Kaufmann, Petra, Dawkins, Hugh Js, Lasko, Paul, Austin, Christopher P, Boycott, Kym M
Published in European journal of human genetics : EJHG (01.12.2017)
Published in European journal of human genetics : EJHG (01.12.2017)
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Journal Article
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
Austin, Christopher P, Williams, David L, Sayed, Ahmed A, Simeonov, Anton, Thomas, Craig J, Inglese, James
Published in Nature medicine (01.04.2008)
Published in Nature medicine (01.04.2008)
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