The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE−/− and LDLr−/− Mice by a Mechanism That Includes Inflammatory Pathways
Rakipovski, Günaj, PhD, Rolin, Bidda, DVM, Nøhr, Jane, PhD, Klewe, Ib, PhD, Frederiksen, Klaus S., PhD, Augustin, Robert, PhD, Hecksher-Sørensen, Jacob, PhD, Ingvorsen, Camilla, PhD, Polex-Wolf, Joseph, PhD, Knudsen, Lotte Bjerre, DMSc
Published in JACC. Basic to translational science (01.12.2018)
Published in JACC. Basic to translational science (01.12.2018)
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Journal Article
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
Zimmermann, Tina, Thomas, Leo, Baader-Pagler, Tamara, Haebel, Peter, Simon, Eric, Reindl, Wolfgang, Bajrami, Besnik, Rist, Wolfgang, Uphues, Ingo, Drucker, Daniel J., Klein, Holger, Santhanam, Rakesh, Hamprecht, Dieter, Neubauer, Heike, Augustin, Robert
Published in Molecular metabolism (Germany) (01.12.2022)
Published in Molecular metabolism (Germany) (01.12.2022)
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Journal Article
The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice
Hutch, Chelsea R., Roelofs, Karen, Haller, April, Sorrell, Joyce, Leix, Kyle, D’Alessio, David D., Augustin, Robert, Seeley, Randy J., Klein, Thomas, Sandoval, Darleen A.
Published in Diabetologia (01.10.2019)
Published in Diabetologia (01.10.2019)
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Journal Article
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application
Löffler, Mona C., Betz, Matthias J., Blondin, Denis P., Augustin, Robert, Sharma, Anand K., Tseng, Yu-Hua, Scheele, Camilla, Zimdahl, Heike, Mark, Michael, Hennige, Anita M., Wolfrum, Christian, Langhans, Wolfgang, Hamilton, Bradford S., Neubauer, Heike
Published in Molecular metabolism (Germany) (01.09.2021)
Published in Molecular metabolism (Germany) (01.09.2021)
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Journal Article
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans
Chae, Heeyoung, Augustin, Robert, Gatineau, Eva, Mayoux, Eric, Bensellam, Mohammed, Antoine, Nancy, Khattab, Firas, Lai, Bao-Khanh, Brusa, Davide, Stierstorfer, Birgit, Klein, Holger, Singh, Bilal, Ruiz, Lucie, Pieper, Michael, Mark, Michael, Herrera, Pedro L., Gribble, Fiona M., Reimann, Frank, Wojtusciszyn, Anne, Broca, Christophe, Rita, Nano, Piemonti, Lorenzo, Gilon, Patrick
Published in Molecular metabolism (Germany) (01.12.2020)
Published in Molecular metabolism (Germany) (01.12.2020)
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Journal Article
GTPase ARFRP1 Is Essential for Normal Hepatic Glycogen Storage and Insulin-Like Growth Factor 1 Secretion
Hesse, Deike, Jaschke, Alexander, Kanzleiter, Timo, Witte, Nicole, Augustin, Robert, Hommel, Angela, Püschel, Gerhard Paul, Petzke, Klaus-Jürgen, Joost, Hans-Georg, Schupp, Michael, Schürmann, Annette
Published in Molecular and Cellular Biology (01.11.2012)
Published in Molecular and Cellular Biology (01.11.2012)
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Journal Article
TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling
Beaton, Nigel, Rudigier, Carla, Moest, Hansjörg, Müller, Sebastian, Mrosek, Nadja, Röder, Eva, Rudofsky, Gottfried, Rülicke, Thomas, Ukropec, Jozef, Ukropcova, Barbara, Augustin, Robert, Neubauer, Heike, Wolfrum, Christian
Published in Molecular metabolism (Germany) (01.11.2015)
Published in Molecular metabolism (Germany) (01.11.2015)
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Journal Article
GLUT8 Contains a [DE]XXXL[LI] Sorting Motif and Localizes to a Late Endosomal/Lysosomal Compartment
Augustin, Robert, Riley, Joan, Moley, Kelle H.
Published in Traffic (Copenhagen, Denmark) (01.12.2005)
Published in Traffic (Copenhagen, Denmark) (01.12.2005)
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Journal Article
Ablation of the Cholesterol Transporter Adenosine Triphosphate-Binding Cassette Transporter G1 Reduces Adipose Cell Size and Protects against Diet-Induced Obesity
Buchmann, Jana, Meyer, Christoph, Neschen, Susanne, Augustin, Robert, Schmolz, Katja, Kluge, Reinhart, Al-Hasani, Hadi, Jürgens, Hella, Eulenberg, Karsten, Wehr, Roland, Dohrmann, Cord, Joost, Hans-Georg, Schürmann, Annette
Published in Endocrinology (Philadelphia) (01.04.2007)
Published in Endocrinology (Philadelphia) (01.04.2007)
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Journal Article
The apical sorting signal for human GLUT9b resides in the N-terminus
Bibee, Kristin P., Augustin, Robert, Gazit, Vered, Moley, Kelle H.
Published in Molecular and cellular biochemistry (01.04.2013)
Published in Molecular and cellular biochemistry (01.04.2013)
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Journal Article
ADP-ribosylation Factor-like GTPase ARFRP1 Is Required for Trans-Golgi to Plasma Membrane Trafficking of E-cadherin
Zahn, Claudia, Jaschke, Alexander, Weiske, Jörg, Hommel, Angela, Hesse, Deike, Augustin, Robert, Lu, Lei, Hong, Wanjin, Florian, Simone, Scheepers, Andrea, Joost, Hans-Georg, Huber, Otmar, Schürmann, Annette
Published in The Journal of biological chemistry (03.10.2008)
Published in The Journal of biological chemistry (03.10.2008)
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Journal Article
Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos
Augustin, Robert, Pocar, Paola, Navarrete-Santos, Anne, Wrenzycki, Christine, Gandolfi, Fulvio, Niemann, Heiner, Fischer, Bernd
Published in Molecular reproduction and development (01.11.2001)
Published in Molecular reproduction and development (01.11.2001)
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Journal Article
Perspectives in weight control in diabetes – Survodutide
Klein, Thomas, Augustin, Robert, Hennige, Anita M.
Published in Diabetes research and clinical practice (01.01.2024)
Published in Diabetes research and clinical practice (01.01.2024)
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Journal Article
The dual GCGR/GLP‐1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection
Thomas, Leo, Martel, Eric, Rist, Wolfgang, Uphues, Ingo, Hamprecht, Dieter, Neubauer, Heike, Augustin, Robert
Published in Diabetes, obesity & metabolism (01.06.2024)
Published in Diabetes, obesity & metabolism (01.06.2024)
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Journal Article
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
Zhang, Qian, Delessa, Challa Tenagne, Augustin, Robert, Bakhti, Mostafa, Colldén, Gustav, Drucker, Daniel J., Feuchtinger, Annette, Caceres, Cristina Garcia, Grandl, Gerald, Harger, Alexandra, Herzig, Stephan, Hofmann, Susanna, Holleman, Cassie Lynn, Jastroch, Martin, Keipert, Susanne, Kleinert, Maximilian, Knerr, Patrick J., Kulaj, Konxhe, Legutko, Beata, Lickert, Heiko, Liu, Xue, Luippold, Gerd, Lutter, Dominik, Malogajski, Emilija, Medina, Marta Tarquis, Mowery, Stephanie A., Blutke, Andreas, Perez-Tilve, Diego, Salinno, Ciro, Sehrer, Laura, DiMarchi, Richard D., Tschöp, Matthias H., Stemmer, Kerstin, Finan, Brian, Wolfrum, Christian, Müller, Timo D.
Published in Cell metabolism (06.04.2021)
Published in Cell metabolism (06.04.2021)
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Journal Article
749-P: Selection of BI 456906 as a Dual GCGR/GLP-1R Agonist Based on In Vitro Potency and In Vivo Target Engagement Biomarkers
AUGUSTIN, ROBERT, THOMAS, LEO, ZIMMERMANN, TINA, SIMON, ERIC, RIST, WOLFGANG, UPHUES, INGO, REINDL, WOLFGANG, KLEIN, THOMAS, NEUBAUER, HEIKE
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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Journal Article