Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections
Spletstoser, Jared T., Dreabit, Jason, Knox, Andrew N., Benowitz, Andrew, Campobasso, Nino, Ward, Paris, Cui, Guanglei, Lewandowski, Thomas, McCloskey, Lynn, Aubart, Kelly M.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Get full text
Journal Article
Comparative Analysis of the Antibacterial Activity of a Novel Peptide Deformylase Inhibitor, GSK1322322
O'DWYER, Karen, HACKEL, Meredith, HIGHTOWER, Sarah, HOBAN, Daryl, BOUCHILLON, Samuel, DONGHUI QIN, AUBART, Kelly, ZALACAIN, Magdalena, BUTLER, Deborah
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Get full text
Journal Article
Potent Sub-MIC Effect of GSK1322322 and Other Peptide Deformylase Inhibitors on In Vitro Growth of Staphylococcus aureus
BUTLER, Deborah, DONGZHAO CHEN, O'DWYER, Karen, LEWANDOWSKI, Thomas, AUBART, Kelly, ZALACAIN, Magdalena
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
Published in Antimicrobial Agents and Chemotherapy (01.01.2014)
Get full text
Journal Article
Staphylococcus aureus Formyl-Methionyl Transferase Mutants Demonstrate Reduced Virulence Factor Production and Pathogenicity
Lewandowski, Thomas, Huang, Jianzhong, Fan, Frank, Rogers, Shannon, Gentry, Daniel, Holland, Reannon, Demarsh, Peter, Aubart, Kelly, Zalacain, Magdalena
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Get full text
Journal Article
Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors
Totoritis, Rachel, Duraiswami, Chaya, Taylor, Amy N, Kerrigan, John J, Campobasso, Nino, Smith, Katherine J, Ward, Paris, King, Bryan W, Murrayz-Thompson, Monique, Jones, Amber D, Van Aller, Glenn S, Aubart, Kelly M, Zalacain, Magdalena, Thrall, Sara H, Meek, Thomas D, Schwartz, Benjamin
Published in Biochemistry (Easton) (09.08.2011)
Published in Biochemistry (Easton) (09.08.2011)
Get full text
Journal Article
Phylogenomic and Biochemical Characterization of Three Legionella pneumophila Polypeptide Deformylases
Huang, Jianzhong, Van Aller, Glenn S, Taylor, Amy N, Kerrigan, John J, Liu, Wu-Schyong, Trulli, Janice M, Lai, Zhihong, Holmes, David, Aubart, Kelly M, Brown, James R, Zalacain, Magdalena
Published in Journal of Bacteriology (01.07.2006)
Published in Journal of Bacteriology (01.07.2006)
Get full text
Journal Article
Mechanism of Time-Dependent Inhibition of Polypeptide Deformylase by Actinonin
Van Aller, Glenn S, Nandigama, Ravi, Petit, Chantal M, DeWolf, Walt E, Quinn, Chad J, Aubart, Kelly M, Zalacain, Magdalena, Christensen, Siegfried B, Copeland, Robert A, Lai, Zhihong
Published in Biochemistry (Easton) (11.01.2005)
Published in Biochemistry (Easton) (11.01.2005)
Get full text
Journal Article
Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection
Hoover, Jennifer, Lewandowski, Thomas, Straub, Robert J, Novick, Steven J, DeMarsh, Peter, Aubart, Kelly, Rittenhouse, Stephen, Zalacain, Magdalena
Published in Antimicrobial agents and chemotherapy (01.01.2016)
Published in Antimicrobial agents and chemotherapy (01.01.2016)
Get full text
Journal Article
In vitro and intracellular activities of peptide deformylase inhibitor GSK1322322 against Legionella pneumophila isolates
Dubois, Jacques, Dubois, Maïtée, Martel, Jean-François, Aubart, Kelly, Butler, Deborah
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Get full text
Journal Article
Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
Min, Sharon, Ingraham, Karen, Huang, Jianzhong, McCloskey, Lynn, Rilling, Sarah, Windau, Anne, Pizzollo, Jason, Butler, Deborah, Aubart, Kelly, Miller, Linda A, Zalacain, Magdalena, Holmes, David J, O'Dwyer, Karen
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Published in Antimicrobial agents and chemotherapy (01.08.2015)
Get full text
Journal Article
Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase
Arat, Seda, Spivak, Aaron, Van Horn, Stephanie, Thomas, Elizabeth, Traini, Christopher, Sathe, Ganesh, Livi, George P, Ingraham, Karen, Jones, Lori, Aubart, Kelly, Holmes, David J, Naderer, Odin, Brown, James R
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Get full text
Journal Article
Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors
Shi, Wei, Ma, Haikun, Duan, Yuejiao, Aubart, Kelly, Fang, Yuhong, Zonis, Rimma, Yang, Liping, Hu, Wenhao
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Get full text
Journal Article
PEPTIDE DEFORMYLASE INHIBITORS
MCKEOWN ROBERT RAHN, GILLIAN JASON MICHAEL, AUBART KELLY MARSHALL, WILLIAMS GLENN R, QIN DONGHUI
Year of Publication 06.08.2014
Get full text
Year of Publication 06.08.2014
Patent
PEPTIDE DEFORMYLASE INHIBITORS
DREABIT JASON CHRISTOPHER, FANG YUHONG, AUBART KELLY M, KNOX ANDREW NICHOLSON, CHRISTENSEN SIEGFRIED BENJAMIN IV, LEE, JIN HWA, BENOWITZ ANDREW B, QIN DONGHUI, NORTON BETH, LIAO XIANGMIN
Year of Publication 12.04.2016
Get full text
Year of Publication 12.04.2016
Patent
Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species
Smith, Kathrine J., Petit, Chantal M., Aubart, Kelly, Smyth, Martin, McManus, Edward, Jones, Jo, Fosberry, Andrew, Lewis, Ceri, Lonetto, Michael, Christensen, Siegfried B.
Published in Protein science (01.02.2003)
Published in Protein science (01.02.2003)
Get full text
Journal Article
PEPTIDE DEFORMYLASE INHIBITORS
FANG YUHONG, AUBART KELLY M, HOFFMAN JAMES, KNOX ANDREW NICHOLSON, SPLETSTOSER JARED T, SHI DONGCHUAN, BENOWITZ ANDREW B, KARPINSKI JOSEPH M, QIN DONGHUI, LIAO XIANGMIN
Year of Publication 28.01.2014
Get full text
Year of Publication 28.01.2014
Patent
PEPTIDE DEFORMYLASE INHIBITORS
CHRISTENSEN SIEGFRIED B. IV, AUBART KELLY M, LEE, JIN HWA, BENOWITZ ANDREW B, KARPINSKI JOSEPH M, SILVA DOMINGOS J
Year of Publication 17.11.2010
Get full text
Year of Publication 17.11.2010
Patent