Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents
Gamage, Swarna A, Spicer, Julie A, Atwell, Graham J, Finlay, Graeme J, Baguley, Bruce C, Denny, William A
Published in Journal of medicinal chemistry (01.07.1999)
Published in Journal of medicinal chemistry (01.07.1999)
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Journal Article
Structure−Activity Relationships for 4-Nitrobenzyl Carbamates of 5-Aminobenz[e]indoline Minor Groove Alkylating Agents as Prodrugs for GDEPT in Conjunction with E. coli Nitroreductase
HAY, Michael P., ATWELL, Graham J., WILSON, William R., PULLEN, Susan M., DENNY, William A.
Published in Journal of medicinal chemistry (05.06.2003)
Published in Journal of medicinal chemistry (05.06.2003)
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Journal Article
DNA-Directed Alkylating Agents. 7. Synthesis, DNA Interaction, and Antitumor Activity of Bis(hydroxymethyl)- and Bis(carbamate)-Substituted Pyrrolizines and Imidazoles
Atwell, Graham J, Fan, Jun-Yao, Tan, Karin, Denny, William A
Published in Journal of medicinal chemistry (19.11.1998)
Published in Journal of medicinal chemistry (19.11.1998)
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Journal Article
Aziridinyldinitrobenzamides: Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase
Helsby, Nuala A, Atwell, Graham J, Yang, Shangjin, Palmer, Brian D, Anderson, Robert F, Pullen, Susan M, Ferry, Dianne M, Hogg, Alison, Wilson, William R, Denny, William A
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Journal Article
Synthesis and Cytotoxicity of 5-Amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2- dihydro-3H-benz[e]indole (Amino-s eco-CBI-TMI) and Related 5-Alkylamino Analogues: New DNA Minor Groove Alkylating Agents
Atwell, Graham J, Tercel, Moana, Boyd, Maruta, Wilson, William R, Denny, William A
Published in Journal of organic chemistry (11.12.1998)
Published in Journal of organic chemistry (11.12.1998)
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Journal Article
An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
Atwell, Graham J, Yang, Shangjin, Denny, William A
Published in European journal of medicinal chemistry (01.10.2002)
Published in European journal of medicinal chemistry (01.10.2002)
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Journal Article
Structure−Activity Relationships for Acridine-Substituted Analogues of the Mixed Topoisomerase I/II Inhibitor N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
Spicer, Julie A, Gamage, Swarna A, Atwell, Graham J, Finlay, Graeme J, Baguley, Bruce C, Denny, William A
Published in Journal of medicinal chemistry (06.06.1997)
Published in Journal of medicinal chemistry (06.06.1997)
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Journal Article
5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: Relationships between Structure and Cytotoxicity for Analogues Bearing Different DNA Minor Groove Binding Subunits
Atwell, Graham J, Milbank, Jared J. B, Wilson, William R, Hogg, Alison, Denny, William A
Published in Journal of medicinal chemistry (26.08.1999)
Published in Journal of medicinal chemistry (26.08.1999)
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Journal Article
Synthesis of 1-Substituted 3-(Chloromethyl)-6-aminoindoline (6-Amino-seco-CI) DNA Minor Groove Alkylating Agents and Structure−Activity Relationships for Their Cytotoxicity
Milbank, Jared B. J, Tercel, Moana, Atwell, Graham J, Wilson, William R, Hogg, Alison, Denny, William A
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
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Journal Article
N-Substituted 2-(2,6-Dinitrophenylamino)propanamides: Novel Prodrugs That Release a Primary Amine via Nitroreduction and Intramolecular Cyclization
Sykes, Bridget M, Atwell, Graham J, Hogg, Alison, Wilson, William R, O'Connor, Charmian J, Denny, William A
Published in Journal of medicinal chemistry (11.02.1999)
Published in Journal of medicinal chemistry (11.02.1999)
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Journal Article
Synthesis and cytotoxicity of amino analogues of the potent DNA alkylating agent seco-CBI-TMI
Atwell, G.J., Wilson, W.R., Denny, W.A.
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
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Journal Article
Hypoxia-Selective Antitumor Agents. 15. Modification of Rate of Nitroreduction and Extent of Lysosomal Uptake by Polysubstitution of 4-(Alkylamino)-5-nitroquinoline Bioreductive Drugs
Siim, Bronwyn G, Atwell, Graham J, Anderson, Robert F, Wardman, Peter, Pullen, Susan M, Wilson, William R, Denny, William A
Published in Journal of medicinal chemistry (25.04.1997)
Published in Journal of medicinal chemistry (25.04.1997)
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Journal Article
Relationships between structure and kinetics of cyclization of 2-aminoaryl amides: potential prodrugs of cyclization-activated aromatic mustards
Atwell, Graham J, Sykes, Bridget M, O'Connor, Charmian J, Denny, William A
Published in Journal of medicinal chemistry (01.02.1994)
Published in Journal of medicinal chemistry (01.02.1994)
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Journal Article
Hypoxia-Selective Antitumor Agents. 9. Structure-Activity Relationships for Hypoxia-Selective Cytotoxicity among Analogs of 5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
Palmer, Brian D, Wilson, William R, Atwell, Graham J, Schultz, Diane, Xu, Xing Z, Denny, William A
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
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Journal Article
Hypoxia-selective antitumor agents. 6. 4-(Alkylamino)nitroquinolines: a new class of hypoxia-selective cytotoxins
Denny, William A, Atwell, Graham J, Roberts, Peter B, Anderson, Robert F, Boyd, Maruta, Lock, Colin J. L, Wilson, William R
Published in Journal of medicinal chemistry (01.12.1992)
Published in Journal of medicinal chemistry (01.12.1992)
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Journal Article
Synthesis, DNA interactions and biological activity of DNA minor groove targeted polybenzamide-linked nitrogen mustards
Atwell, Graham J., Yaghi, Basma M., Turner, Paul R., Boyd, Maruta, O'Connor, Charmian J., Ferguson, Lynnette R., Baguley, Bruce C., Denny, William A.
Published in Bioorganic & medicinal chemistry (01.06.1995)
Published in Bioorganic & medicinal chemistry (01.06.1995)
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Journal Article