A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding
NAKAYAMA, Shintaro, ATSUMI, Ryo, TAKAKUSA, Hideo, KOBAYASHI, Yoshimasa, KURIHARA, Atsushi, NAGAI, Yoko, NAKAI, Daisuke, OKAZAKI, Osamu
Published in Drug metabolism and disposition (01.09.2009)
Published in Drug metabolism and disposition (01.09.2009)
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Journal Article
Identification of Influx Transporter for the Quinolone Antibacterial Agent Levofloxacin
Maeda, Tomoji, Takahashi, Koichi, Ohtsu, Naoko, Oguma, Toshihiro, Ohnishi, Toshimasa, Atsumi, Ryo, Tamai, Ikumi
Published in Molecular pharmaceutics (01.01.2007)
Published in Molecular pharmaceutics (01.01.2007)
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Journal Article
Metabolism of Ticlopidine in Rats: Identification of the Main Biliary Metabolite as a Glutathione Conjugate of Ticlopidine S-Oxide
SHIMIZU, Shinji, ATSUMI, Ryo, NAKAZAWA, Tsunenori, FUJIMAKI, Yuko, SUDO, Kenichi, OKAZAKI, Osamu
Published in Drug metabolism and disposition (01.09.2009)
Published in Drug metabolism and disposition (01.09.2009)
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Journal Article
Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice
Arakawa, Shingo, Maejima, Takanori, Fujimoto, Kazunori, Yamaguchi, Takashi, Yagi, Masae, Sugiura, Tomomi, Atsumi, Ryo, Yamazoe, Yasushi
Published in Journal of toxicological sciences (2012)
Published in Journal of toxicological sciences (2012)
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Journal Article
Establishment and functional characterization of an in vitro model of the blood–brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes
Gaillard, Pieter Jaap, Voorwinden, Levina Helena, Nielsen, Jette Lyngholm, Ivanov, Alexei, Atsumi, Ryo, Engman, Helena, Ringbom, Carina, de Boer, Albertus Gerrit, Breimer, Douwe Durk
Published in European journal of pharmaceutical sciences (2001)
Published in European journal of pharmaceutical sciences (2001)
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Journal Article
DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
Ogitani, Yusuke, Aida, Tetsuo, Hagihara, Katsunobu, Yamaguchi, Junko, Ishii, Chiaki, Harada, Naoya, Soma, Masako, Okamoto, Hiromi, Oitate, Masataka, Arakawa, Shingo, Hirai, Takehiro, Atsumi, Ryo, Nakada, Takashi, Hayakawa, Ichiro, Abe, Yuki, Agatsuma, Toshinori
Published in Clinical cancer research (15.10.2016)
Published in Clinical cancer research (15.10.2016)
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Journal Article
Synthesis and Antitumor Activity of Novel Pyrimidinyl Pyrazole Derivatives. III. Synthesis and Antitumor Activity of 3-Phenylpiperazinyl-1-trans-propenes
Naito, Hiroyuki, Ohsuki, Satoru, Atsumi, Ryo, Minami, Megumi, Mochizuki, Mineko, Hirotani, Kenji, Kumazawa, Eiji, Ejima, Akio
Published in Chemical & pharmaceutical bulletin (01.02.2005)
Published in Chemical & pharmaceutical bulletin (01.02.2005)
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Journal Article
Validation study of a method for assaying DE-310, a macromolecular carrier conjugate containing an anti-tumor camptothecin derivative, and the free drug in human plasma by HPLC and LC/MS/MS
OGUMA, Toshihiro, CICCI, Dino, GAUDETTE, Fleur, GAUTHIER-DUBOIS, Ginette, GUILBAUD, Rudolf, ATSUMI, Ryo
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (25.04.2005)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (25.04.2005)
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Journal Article
Synthesis and Antitumor Activity of Novel Pyrimidinyl Pyrazole Derivatives. II. Optimization of the Phenylpiperazine Moiety of 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes
Naito, Hiroyuki, Ohsuki, Satoru, Sugimori, Masamichi, Atsumi, Ryo, Minami, Megumi, Nakamura, Yoshihide, Ishii, Mineko, Hirotani, Kenji, Kumazawa, Eiji, Ejima, Akio
Published in Chemical & pharmaceutical bulletin (01.04.2002)
Published in Chemical & pharmaceutical bulletin (01.04.2002)
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Journal Article
Identification of dominant genetic markers relevant to male sex determination in mulberry (Morus alba L.)
Atsumi, Ryo, Nishihara, Rio, Tarora, Kazuhiko, Urasaki, Naoya, Matsumura, Hideo
Published in Euphytica (01.11.2019)
Published in Euphytica (01.11.2019)
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Journal Article
Liquid chromatographic assays for DE-310, a novel camptothecin analog, and two major enzymatic products in human matrices
Soepenberg, Otto, de Bruijn, Peter, Verweij, Jaap, Atsumi, Ryo, Sparreboom, Alex
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (05.01.2004)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (05.01.2004)
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Journal Article
First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (ATL)
Morishima, Satoko, Ishitsuka, Kenji, Izutsu, Koji, Kusumoto, Shigeru, Makiyama, Junya, Utsunomiya, Atae, Nosaka, Kisato, Ishida, Takashi, Imaizumi, Yoshitaka, Yamauchi, Nobuhiko, Araki, Kazushi, Adachi, Nobuaki, Yamashita, Tomonari, Atsumi, Ryo, Tsukasaki, Kunihiro, Tobinai, Kensei
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Population Pharmacokinetic and Exposure-Response Modeling for the EZH1/2 Dual Inhibitor DS-3201b in Patients with Non-Hodgkin Lymphomas
Atsumi, Ryo, Yoshiba, Satoshi, Maruyama, Dai, Tobinai, Kensei, Ishida, Takashi, Ishitsuka, Kenji, Imaizumi, Yoshitaka, Takeuchi, Shogo, Tsukasaki, Kunihiro, Adachi, Nobuaki, Fujitani, Sumiaki, Tachibana, Masaya, Yoshihara, Kazutaka, Ishizuka, Hitoshi
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice
Shimizu, Shinji, Atsumi, Ryo, Itokawa, Kenichi, Iwasaki, Masaru, Aoki, Takanori, Ono, Chiho, Izumi, Takashi, Sudo, Kenichi, Okazaki, Osamu
Published in Archives of toxicology (01.07.2009)
Published in Archives of toxicology (01.07.2009)
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Journal Article
Metabolism of Irinotecan to SN-38 in a Tissue-Isolated Tumor Model
ATSUMI, Ryo, OKAZAKI, Osamu, HAKUSUI, Hideo
Published in Biological & pharmaceutical bulletin (1995)
Published in Biological & pharmaceutical bulletin (1995)
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Journal Article
Abstract A145: DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a potent anti-tumor efficacy with differentiation from T-DM1 in preclinical studies
Ogitani, Yusuke, Yamaguchi, Junko, Ishii, Chiaki, Hirai, Takehiro, Atsumi, Ryo, Morita, Koji, Hayakawa, Ichiro, Naito, Hiroyuki, Masuda, Takeshi, Nakada, Takashi, Jikoh, Takahiro
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model
Shimizu, Shinji, Atsumi, Ryo, Nakazawa, Tsunenori, Izumi, Takashi, Sudo, Kenichi, Okazaki, Osamu, Saji, Hideo
Published in Archives of toxicology (01.04.2011)
Published in Archives of toxicology (01.04.2011)
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Journal Article
Pharmacokinetics of SN-38 ((+)-(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)-indolizino(1,2-b)quinoline-3,14(4H,12H)-dione), an Active Metabolite of Irinotecan, after a Single Intravenous Dosing of 14C-SN-38 to Rats
ATSUMI, Ryo, OKAZAKI, Osamu, HAKUSUI, Hideo
Published in Biological & pharmaceutical bulletin (1995)
Published in Biological & pharmaceutical bulletin (1995)
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