Reactions of acyl nitroso compounds with amines: Production of nitroxyl (HNO) with the preparation of amides
Atkinson, Robert N, Storey, Bernadette M, King, S.Bruce
Published in Tetrahedron letters (23.12.1996)
Published in Tetrahedron letters (23.12.1996)
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Factors Influencing Agonist Potency and Selectivity for the Opioid δ Receptor Are Revealed in Structure−Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides
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Published in Journal of medicinal chemistry (15.03.2001)
Published in Journal of medicinal chemistry (15.03.2001)
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HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
WOLF GOUVEIA LILLI ANN, CHRISTOS THOMAS EUGENE, AMATO GEORGE S, SUTO MARK J, ATKINSON ROBERT N, BAROLLI MARIA GRACIELA
Year of Publication 30.04.2010
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Year of Publication 30.04.2010
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Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Na(v)1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain
Kort, Michael E., Drizin, Irene, Gregg, Robert J., Scanio, Marc J. C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Johnson, Matthew S., Pacofsky, Gregory J., Thomas, James B., Carroll, William A., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C., Murray, Bernard P., Liu, Jinrong, Werness, Stephen, Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Chapman, Mark L., Marron, Brian E.
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine
Carroll, F. Ivy, Robinson, T. Philip, Brieaddy, Lawrence E., Atkinson, Robert N., Mascarella, S. Wayne, Damaj, M. Imad, Martin, Billy R., Navarro, Hernan A.
Published in Journal of medicinal chemistry (13.12.2007)
Published in Journal of medicinal chemistry (13.12.2007)
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A-887826 is a structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Zhang, Xu-Feng, Shieh, Char-Chang, Chapman, Mark L., Matulenko, Mark A., Hakeem, Ahmed H., Atkinson, Robert N., Kort, Michael E., Marron, Brian E., Joshi, Shailen, Honore, Prisca, Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F.
Published in Neuropharmacology (01.09.2010)
Published in Neuropharmacology (01.09.2010)
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Journal Article
A-887826 is a structurally novel, potent and voltage-dependent Na sub(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Zhang, Xu-Feng, Shieh, Char-Chang, Chapman, Mark L, Matulenko, Mark A, Hakeem, Ahmed H, Atkinson, Robert N, Kort, Michael E, Marron, Brian E, Joshi, Shailen, Honore, Prisca, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F
Published in Neuropharmacology (01.09.2010)
Published in Neuropharmacology (01.09.2010)
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Journal Article
A-887826 is a structurally novel, potent and voltage-dependent Na v1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Zhang, Xu-Feng, Shieh, Char-Chang, Chapman, Mark L., Matulenko, Mark A., Hakeem, Ahmed H., Atkinson, Robert N., Kort, Michael E., Marron, Brian E., Joshi, Shailen, Honore, Prisca, Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F.
Published in Neuropharmacology (2010)
Published in Neuropharmacology (2010)
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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na v1.8 sodium channel with efficacy in a model of neuropathic pain
Scanio, Marc J.C., Shi, Lei, Drizin, Irene, Gregg, Robert J., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Liu, Yi, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda H., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Knox, Alison, Werness, Stephen, Antonio, Brett, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Marron, Brian E., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (2010)
Published in Bioorganic & medicinal chemistry (2010)
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Journal Article
Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Na v 1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain
Kort, Michael E., Drizin, Irene, Gregg, Robert J., Scanio, Marc J. C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Johnson, Matthew S., Pacofsky, Gregory J., Thomas, James B., Carroll, William A., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C., Murray, Bernard P., Liu, Jinrong, Werness, Stephen, Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Chapman, Mark L., Marron, Brian E.
Published in Journal of medicinal chemistry (01.02.2008)
Published in Journal of medicinal chemistry (01.02.2008)
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Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist
Thomas, James B, Atkinson, Robert N, Vinson, N Ariane, Catanzaro, Jennifer L, Perretta, Carin L, Fix, Scott E, Mascarella, S Wayne, Rothman, Richard B, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F Ivy
Published in Journal of medicinal chemistry (03.07.2003)
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Published in Journal of medicinal chemistry (03.07.2003)
Journal Article
Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidiny l]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide as a novel potent and selective opioid K receptor antagonist
THOMAS, James B, ATKINSON, Robert N, CANTRELL, Buddy E, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, VINSON, N. Ariane, CATANZARO, Jennifer L, PERRETTA, Carin L, FIX, Scott E, MASCARELLA, S. Wayne, ROTHMAN, Richard B, HENG XU, DERSCH, Christina M
Published in Journal of medicinal chemistry (2003)
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Published in Journal of medicinal chemistry (2003)
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Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans
Thomas, James B, Atkinson, Robert N, Namdev, Nivedita, Rothman, Richard B, Gigstad, Kenneth M, Fix, Scott E, Mascarella, S Wayne, Burgess, Jason P, Vinson, N Ariane, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F Ivy
Published in Journal of medicinal chemistry (01.08.2002)
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Published in Journal of medicinal chemistry (01.08.2002)
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Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase
Atkinson, Robert N., King, S. Bruce
Published in Bioorganic & medicinal chemistry letters (18.10.1999)
Published in Bioorganic & medicinal chemistry letters (18.10.1999)
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Journal Article
Identification of the first trans-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid k receptor antagonist activity
THOMAS, James B, ATKINSON, Robert N, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, ROTHMAN, Richard B, FIX, Scott E, MASCARELLA, S. Wayne, VINSON, N. Ariane, HENG XU, DERSCH, Christina M, LU, Y.-F, CANTRELL, Buddy E
Published in Journal of medicinal chemistry (2001)
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Published in Journal of medicinal chemistry (2001)
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Discovery of an opioid κK receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphans
THOMAS, James B, ATKINSON, Robert N, DERSCH, Christina M, CANTRELL, Buddy E, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, NAMDEV, Nivedita, ROTHMAN, Richard B, GIGSTAD, Kenneth M, FIX, Scott E, MASCARELLA, S. Wayne, BURGESS, Jason P, VINSON, N. Ariane, HENG XU
Published in Journal of medicinal chemistry (2002)
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Published in Journal of medicinal chemistry (2002)
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