A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
Zhang, Xu-Feng, Shieh, Char-Chang, Chapman, Mark L, Matulenko, Mark A, Hakeem, Ahmed H, Atkinson, Robert N, Kort, Michael E, Marron, Brian E, Joshi, Shailen, Honore, Prisca, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F
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Published in Neuropharmacology (01.09.2010)
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Synthesis of bridged analogs of epibatidine. 3-Chloro-5,7,8,9,9a,10-hexahydro-7,10-methanopyrrolo[1,2- b]-2,6-naphthyridine and 2-chloro-5,5a,6,7,8,10-hexahydro-5,8-methanopyrrolo[2,1- b]-1,7-naphthyridine
Brieaddy, Lawrence E, Wayne Mascarella, S, Navarro, Hernán A, Atkinson, Robert N, Damaj, M.I, Martin, Billy R, Carroll, F.Ivy
Published in Tetrahedron letters (04.06.2001)
Published in Tetrahedron letters (04.06.2001)
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Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain
Kort, Michael E, Drizin, Irene, Gregg, Robert J, Scanio, Marc J. C, Shi, Lei, Gross, Michael F, Atkinson, Robert N, Johnson, Matthew S, Pacofsky, Gregory J, Thomas, James B, Carroll, William A, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C, Murray, Bernard P, Liu, Jinrong, Werness, Stephen, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Chapman, Mark L, Marron, Brian E
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain
Scanio, Marc J C, Shi, Lei, Drizin, Irene, Gregg, Robert J, Atkinson, Robert N, Thomas, James B, Johnson, Matthew S, Chapman, Mark L, Liu, Dong, Krambis, Michael J, Liu, Yi, Shieh, Char-Chang, Zhang, Xufeng, Simler, Gricelda H, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C, Knox, Alison, Werness, Stephen, Antonio, Brett, Krafte, Douglas S, Jarvis, Michael F, Faltynek, Connie R, Marron, Brian E, Kort, Michael E
Published in Bioorganic & medicinal chemistry (15.11.2010)
Published in Bioorganic & medicinal chemistry (15.11.2010)
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Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives
Kort, Michael E, Atkinson, Robert N, Thomas, James B, Drizin, Irene, Johnson, Matthew S, Secrest, Matthew A, Gregg, Robert J, Scanio, Marc J C, Shi, Lei, Hakeem, Ahmed H, Matulenko, Mark A, Chapman, Mark L, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Marron, Brian E
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist
Thomas, James B, Atkinson, Robert N, Vinson, N. Ariane, Catanzaro, Jennifer L, Perretta, Carin L, Fix, Scott E, Mascarella, S. Wayne, Rothman, Richard B, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity
Thomas, James B, Atkinson, Robert N, Rothman, Richard B, Fix, Scott E, Mascarella, S. Wayne, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Lu, Y. -F, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain
Drizin, Irene, Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Carroll, William A., Marron, Brian E., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhu, Chang Z., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Roeloffs, Rosemarie, Werness, Stephen, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Tackling the burden of injury in Australasia: developing a binational trauma registry
Davey, Tamzyn M, Pollard, Cliff W, Aitken, Leanne M, Fitzgerald, Mark, Bellamy, Nicholas, Cass, Daniel, Danne, Peter D, Griggs, William M, Cameron, Peter A, Atkinson, Robert N, Hamill, James, Rao, Sudhakar, Richardson, Drew B, O'Connor, Christine
Published in Medical journal of Australia (06.11.2006)
Published in Medical journal of Australia (06.11.2006)
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Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of Bridged and Fused Ring Analogues of Epibatidine
Carroll, F. Ivy, Robinson, T. Philip, Brieaddy, Lawrence E, Atkinson, Robert N, Mascarella, S. Wayne, Damaj, M. Imad, Martin, Billy R, Navarro, Hernán A
Published in Journal of medicinal chemistry (13.12.2007)
Published in Journal of medicinal chemistry (13.12.2007)
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Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives
Kort, Michael E., Atkinson, Robert N., Thomas, James B., Drizin, Irene, Johnson, Matthew S., Secrest, Matthew A., Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Hakeem, Ahmed H., Matulenko, Mark A., Chapman, Mark L., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C., Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Marron, Brian E.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Successful early mobilization of major cuff repair using a suture post
Atkinson, Robert N., Comley, Andrew S., Van Essen, John, Hallam, Peter J., Ashwood, Neil, Fogg, Quentin A.
Published in Journal of shoulder and elbow surgery (01.03.2006)
Published in Journal of shoulder and elbow surgery (01.03.2006)
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Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans
Thomas, James B, Atkinson, Robert N, Namdev, Nivedita, Rothman, Richard B, Gigstad, Kenneth M, Fix, Scott E, Mascarella, S. Wayne, Burgess, Jason P, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Reactions of acyl nitroso compounds with amines: Production of nitroxyl (HNO) with the preparation of amides
Atkinson, Robert N, Storey, Bernadette M, King, S.Bruce
Published in Tetrahedron letters (23.12.1996)
Published in Tetrahedron letters (23.12.1996)
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