MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans
Atack, J R, Wafford, K A, Street, L J, Dawson, G R, Tye, S, Van Laere, K, Bormans, G, Sanabria-Bohórquez, S M, De Lepeleire, I, de Hoon, J N, Van Hecken, A, Burns, H D, McKernan, R M, Murphy, M G, Hargreaves, R J
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
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Journal Article
Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist
Atack, J R, Hallett, D J, Tye, S, Wafford, K A, Ryan, C, Sanabria-Bohórquez, S M, Eng, Wai-Si, Gibson, R E, Burns, H D, Dawson, G R, Carling, R W, Street, L J, Pike, A, De Lepeleire, I, Van Laere, K, Bormans, G, de Hoon, J N, Van Hecken, A, McKernan, R M, Murphy, M G, Hargreaves, R J
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
Published in Journal of psychopharmacology (Oxford) (01.03.2011)
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Journal Article
Structure of Inositol Monophosphatase, the Putative Target of Lithium Therapy
Bone, Roger, Springer, James P., Atack, John R.
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.1992)
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Journal Article
Both α2 and α3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm
Morris, H. V., Dawson, G. R., Reynolds, D. S., Atack, J. R., Stephens, D. N.
Published in The European journal of neuroscience (01.05.2006)
Published in The European journal of neuroscience (01.05.2006)
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Journal Article
Inositol monophosphatase — a putative target for Li + in the treatment of bipolar disorder
Atack, John R., Broughton, Howard B., Pollack, Scott J.
Published in Trends in Neurosciences (01.08.1995)
Published in Trends in Neurosciences (01.08.1995)
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Journal Article
Cerebrospinal fluid production is reduced in healthy aging
May, C, Kaye, J A, Atack, J R, Schapiro, M B, Friedland, R P, Rapoport, S I
Published in Neurology (01.03.1990)
Published in Neurology (01.03.1990)
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Journal Article
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease
Perry, E K, Curtis, M, Dick, D J, Candy, J M, Atack, J R, Bloxham, C A, Blessed, G, Fairbairn, A, Tomlinson, B E, Perry, R H
Published in Journal of neurology, neurosurgery and psychiatry (01.05.1985)
Published in Journal of neurology, neurosurgery and psychiatry (01.05.1985)
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Journal Article
cDNA cloning of human and rat brain myo-inositol monophosphatase : expression and characterization of the human recombinant enzyme
MCALLISTER, G, WHITING, P, HAMMOND, E. A, KNOWLES, M. R, ATACK, J., BAILEY, F. J, MAIGETTER, R, RAGAN, C. I
Published in Biochemical journal (15.06.1992)
Published in Biochemical journal (15.06.1992)
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Journal Article
Pharmacological evaluation of the cholinergic system in progressive supranuclear palsy
Litvan, I, Blesa, R, Clark, K, Nichelli, P, Atack, J R, Mouradian, M M, Grafman, J, Chase, T N
Published in Annals of neurology (01.07.1994)
Published in Annals of neurology (01.07.1994)
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Journal Article
Alpha2-containing GABA A receptors are involved in mediating stimulant effects of cocaine
Morris, H.V., Dawson, G.R., Reynolds, D.S., Atack, J.R., Rosahl, T.W., Stephens, D.N.
Published in Pharmacology, biochemistry and behavior (01.07.2008)
Published in Pharmacology, biochemistry and behavior (01.07.2008)
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Journal Article
Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers
Atack, J R, Prior, A M, Fletcher, S R, Quirk, K, McKernan, R, Ragan, C I
Published in The Journal of pharmacology and experimental therapeutics (01.07.1994)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1994)
Journal Article
GABAA α1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment
REYNOLDS, D. S, O'MEARA, G. F, NEWMAN, R. J, BROMIDGE, F. A, ATACK, J. R, WHITING, P. J, ROSAHL, T. W, DAWSON, G. R
Published in Neuropharmacology (01.02.2003)
Published in Neuropharmacology (01.02.2003)
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