Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases
Caldwell, Richard D, Qiu, Hui, Askew, Ben C, Bender, Andrew T, Brugger, Nadia, Camps, Montserrat, Dhanabal, Mohanraj, Dutt, Vikram, Eichhorn, Thomas, Gardberg, Anna S, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Healey, Brian, Hodous, Brian L, Huck, Bayard R, Johnson, Theresa L, Jones, Christopher, Jones, Reinaldo C, Mochalkin, Igor, Morandi, Federica, Nguyen, Ngan, Meyring, Michael, Potnick, Justin R, Santos, Dusica Cvetinovic, Schmidt, Ralf, Sherer, Brian, Shutes, Adam, Urbahns, Klaus, Follis, Ariele Viacava, Wegener, Ansgar A, Zimmerli, Simone C, Liu-Bujalski, Lesley
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered α v β 3 Integrin Antagonist, for the Treatment of Retinal Diseases
Askew, Ben C, Furuya, Takeru, Edwards, D Scott
Published in The Journal of pharmacology and experimental therapeutics (01.08.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2018)
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Nonpeptide α vβ 3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone
Whitman, David B., Askew, Ben C., Duong, Le T., Fernandez-Metzler, Carmen, Halczenko, Wasyl, Hartman, George D., Hutchinson, John H., Leu, Chih-Tai, Prueksaritanont, Thomayant, Rodan, Gideon A., Rodan, Sevgi B., Duggan, Mark E.
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
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FLUORINATED INTEGRIN ANTAGONISTS
EDWARDS D. SCOTT, ASKEW BEN C, HEIDEBRECHT RICHARD W, DUGGAN MARK E, FURUYA TAKERU
Year of Publication 14.10.2015
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Year of Publication 14.10.2015
Patent
Non-peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-amino acids as aspartic acid replacements
COLEMAN, Paul J, BRASHEAR, Karen M, RODAN, Gideon A, LEU, Chih-Tai, PRUEKSARITANONT, Thomayant, FERNANDEZ-METZLER, Carmen, MA, Bennett, LIBBY, Laura A, MERKLE, Kara M, STUMP, Gary L, WALLACE, Audrey A, LYNCH, Joseph J, HUNT, Cecilia A, LYNCH, Robert, DUGGAN, Mark E, HOFFMAN, William F, HUTCHINSON, John H, BRESLIN, Michael J, MCVEAN, Carol A, ASKEW, Ben C, HARTMAN, George D, RODAN, Sevgi B
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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Journal Article
Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone
WHITMAN, David B, ASKEW, Ben C, RODAN, Sevgi B, DUGGAN, Mark E, DUONG, Le T, FERNANDEZ-METZLER, Carmen, HALCZENKO, Wasyl, HARTMAN, George D, HUTCHINSON, John H, LEU, Chih-Tai, PRUEKSARITANONT, Thomayant, RODAN, Gideon A
Published in Bioorganic & medicinal chemistry letters (01.09.2004)
Published in Bioorganic & medicinal chemistry letters (01.09.2004)
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Nonpeptide αvβ3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent αvβ3 Antagonists for the Prevention and Treatment of Osteoporosis
Coleman, Paul J, Brashear, Karen M, Askew, Ben C, Hutchinson, John H, McVean, Carol A, Duong, Le T, Feuston, Bradley P, Fernandez-Metzler, Carmen, Gentile, Michael A, Hartman, George D, Kimmel, Donald B, Leu, Chih-Tai, Lipfert, Lorraine, Merkle, Kara, Pennypacker, Brenda, Prueksaritanont, Thomayant, Rodan, Gideon A, Wesolowski, Gregg A, Rodan, Sevgi B, Duggan, Mark E
Published in Journal of medicinal chemistry (23.09.2004)
Published in Journal of medicinal chemistry (23.09.2004)
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Journal Article
Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered αvβ3 Integrin Antagonist, for the Treatment of Retinal Diseases
Askew, Ben C, Furuya, Takeru, Edwards, D Scott
Published in The Journal of pharmacology and experimental therapeutics (01.08.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2018)
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Nonpeptide Glycoprotein IIb/IIIa Inhibitors. 15. Antithrombotic Efficacy of L-738,167, a Long-Acting GPIIb/IIIa Antagonist, Correlates with Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation but not with Bleeding Time Prolongation
Cook, J J, Sitko, G R, Holahan, M A, Stranieri, M T, Glass, J D, Askew, B C, McIntyre, C J, Claremon, D A, Baldwin, J J, Hartman, G D, Gould, R J, Lynch, Jr, J J
Published in The Journal of pharmacology and experimental therapeutics (01.05.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.05.1997)
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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors
Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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