Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors
Toney, Jeffrey H., Cleary, Kelly A., Hammond, Gail G., Yuan, Xiling, May, Walter J., Hutchins, Steven M., Ashton, Wallace T., Vanderwall, Dana E.
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Published in Bioorganic & medicinal chemistry letters (20.09.1999)
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9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication
Field, A K, Davies, M E, DeWitt, C, Perry, H C, Liou, R, Germershausen, J, Karkas, J D, Ashton, W T, Johnston, D B, Tolman, R L
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1983)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1983)
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Assessment of a selective inhibitor of herpes simplex virus thymidine kinase (L-653,180) as therapy for experimental recurrent genital herpes
BOURNE, N, BRAVO, F. J, ASHTON, W. T, MEURER, L. C, TOLMAN, R. L, KARKAS, J. D, STANBERRY, L. R
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Published in Antimicrobial Agents and Chemotherapy (01.09.1992)
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Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates
Ashton, Wallace T, Hutchins, Steven M, Greenlee, William J, Doss, George A, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A, Chen, Tsing Bau, Zingaro, Gloria J
Published in Journal of medicinal chemistry (12.11.1993)
Published in Journal of medicinal chemistry (12.11.1993)
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Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles
Ashton, Wallace T, Cantone, Christine L, Chang, Linda L, Hutchins, Steven M, Strelitz, Robert A, MacCoss, Malcolm, Chang, Raymond S. L, Lotti, Victor J, Faust, Kristie A
Published in Journal of medicinal chemistry (05.03.1993)
Published in Journal of medicinal chemistry (05.03.1993)
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Synthesis and antiherpetic activity of (.+-.)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds
Ashton, Wallace T, Meurer, Laura Canning, Cantone, Christine L, Field, A. Kirk, Hannah, John, Karkas, John D, Liou, Richard, Patel, Gool F, Perry, Helen C
Published in Journal of medicinal chemistry (01.12.1988)
Published in Journal of medicinal chemistry (01.12.1988)
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Inhibition of the Mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids
GRAHAM, D. W, ASHTON, W. T, BARASH, L, BROWN, J. E, BROWN, R. D, CANNING, L. F, CHEN, A, SPRINGER, J. P, ROGERS, E. F
Published in Journal of medicinal chemistry (01.06.1987)
Published in Journal of medicinal chemistry (01.06.1987)
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Renin inhibitors containing C-termini derived from mercaptoheterocycles
Ashton, Wallace T, Cantone, Christine L, Meurer, Laura C, Tolman, Richard L, Greenlee, William J, Patchett, Arthur A, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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Enzymatic phosphorylation of the antiherpetic agent 9-[(2,3-dihydroxy-1-propoxy)methyl]guanine
Karkas, J. D, Ashton, W. T, Canning, L. F, Liou, R, Germershausen, J, Bostedor, R, Arison, B, Field, A. K, Tolman, R. L
Published in Journal of medicinal chemistry (01.05.1986)
Published in Journal of medicinal chemistry (01.05.1986)
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Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity
Ashton, Wallace T., Sisco, Rosemary M., Kieczykowski, Gerard R., Yang, Yi Tien, Yudkovitz, Joel B., Cui, Jisong, Mount, George R., Ren, Rena Ning, Wu, Tsuei-Ju, Shen, Xiaolan, Lyons, Kathryn A., Mao, An-Hua, Carlin, Josephine R., Karanam, Bindhu V., Vincent, Stella H., Cheng, Kang, Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (08.10.2001)
Published in Bioorganic & medicinal chemistry letters (08.10.2001)
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Substituted Indole-5-carboxamides and -acetamides as Potent Nonpeptide GnRH Receptor Antagonists
Ashton, Wallace T., Sisco, Rosemary M., Yang, Yi Tien, Lo, Jane-Ling, Yudkovitz, Joel B., Cheng, Kang, Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids
Ashton, Wallace T, Cantone, Christine L, Tolman, Richard L, Greenlee, William J, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus
Ashton, Wallace T., Sisco, Rosemary M., Yang, Yi Tien, Lo, Jane-Ling, Yudkovitz, Joel B., Gibbons, Patrice H., Mount, George R., Ren, Rena Ning, Butler, Bridget S., Cheng, Kang, Goulet, Mark T.
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
Published in Bioorganic & medicinal chemistry letters (09.07.2001)
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Inhibition of human purine nucleoside phosphorylase by acyclic nucleosides and nucleotides
Stein, J M, Stoeckler, J D, Li, S Y, Tolman, R L, MacCoss, M, Chen, A, Karkas, J D, Ashton, W T, Parks, Jr, R E
Published in Biochemical pharmacology (15.04.1987)
Published in Biochemical pharmacology (15.04.1987)
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Triazolinone Biphenylsulfonamides as Angiotensin II Receptor Antagonists with High Affinity for Both the AT1 and AT2 Subtypes
Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Chen, Tsing-Bau, O'Malley, Stacey S, Zingaro, Gloria J, Siegl, Peter K. S, Kivlighn, Salah D, Lotti, Victor J
Published in Journal of medicinal chemistry (01.12.1994)
Published in Journal of medicinal chemistry (01.12.1994)
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In vivo pharmacology of L-159,913, a new highly potent and selective nonpeptide angiotensin II receptor antagonist
Gabel, R A, Kivlighn, S D, Zingaro, G J, Schorn, T W, Schaffer, L W, Ashton, W T, Chang, L L, Flanagan, K, Greenlee, W J, Siegl, P K
Published in Clinical and experimental hypertension (1993) (1995)
Published in Clinical and experimental hypertension (1993) (1995)
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Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity
Ashton, Wallace T, Chang, Linda L, Flanagan, Kelly L, Hutchins, Steven M, Naylor, Elizabeth M, Chakravarty, Prasun K, Patchett, Arthur A, Greenlee, William J, Chen, Tsing-Bau
Published in Journal of medicinal chemistry (01.08.1994)
Published in Journal of medicinal chemistry (01.08.1994)
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Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes
Chang, Linda L, Ashton, Wallace T, Flanagan, Kelly L, Chen, Tsing-Bau, O'Malley, Stacey S, Zingaro, Gloria J, Kivlighn, Salah D, Siegl, Peter K. S, Lotti, Victor J
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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5-Halo-6-phenyl pyrimidinones and 8-substituted guanosines: Biological response modifiers with similar effects on B cells
Wicker, Linda S., Ashton, Wallace T., Boltz, Robert C., Meurer, Laura C., Miller, Beverly J., Nichols, Elizabeth A., Sigal, Nolan H., Tolman, Richard L., Peterson, Laurence B.
Published in Cellular immunology (01.03.1988)
Published in Cellular immunology (01.03.1988)
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Synthesis and structure-activity relationships of a novel series of non-peptide AT2-selective angiotensin II receptor antagonists
WU, M. T, IKELER, T. J, ASHTON, W. T, CHANG, R. S. L, LOTTI, V. J, GREENLEE, W. J
Published in Bioorganic & medicinal chemistry letters (01.10.1993)
Published in Bioorganic & medicinal chemistry letters (01.10.1993)
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