Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours
Mowday, Alexandra M, Dubois, Ludwig J, Kubiak, Aleksandra M, Chan-Hyams, Jasmine V E, Guise, Christopher P, Ashoorzadeh, Amir, Lambin, Philippe, Ackerley, David F, Smaill, Jeff B, Minton, Nigel P, Theys, Jan, Patterson, Adam V
Published in Cancer gene therapy (01.02.2022)
Published in Cancer gene therapy (01.02.2022)
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Journal Article
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug
Rich, Michelle H., Sharrock, Abigail V., Ashoorzadeh, Amir, Patterson, Adam V., Smaill, Jeff B., Ackerley, David F.
Published in Biotechnology letters (2021)
Published in Biotechnology letters (2021)
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Journal Article
Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling
Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R, Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O, Smaill, Jeff B, Patterson, Adam V
Published in Frontiers in pharmacology (08.02.2022)
Published in Frontiers in pharmacology (08.02.2022)
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Journal Article
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3
Abbattista, Maria R, Ashoorzadeh, Amir, Guise, Christopher P, Mowday, Alexandra M, Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O, Bull, Matthew R, Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A, Lambie, Neil K, Dachs, Gabi U, Ackerley, David F, Smaill, Jeff B, Patterson, Adam V
Published in Pharmaceuticals (Basel, Switzerland) (26.11.2021)
Published in Pharmaceuticals (Basel, Switzerland) (26.11.2021)
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Journal Article
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications
Ashoorzadeh, Amir, Mowday, Alexandra M, Guise, Christopher P, Silva, Shevan, Bull, Matthew R, Abbattista, Maria R, Copp, Janine N, Williams, Elsie M, Ackerley, David F, Patterson, Adam V, Smaill, Jeff B
Published in Pharmaceuticals (Basel, Switzerland) (01.02.2022)
Published in Pharmaceuticals (Basel, Switzerland) (01.02.2022)
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Journal Article
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia
Guise, Christopher P, Mowday, Alexandra M, Ashoorzadeh, Amir, Yuan, Ran, Lin, Wan-Hua, Wu, Dong-Hai, Smaill, Jeff B, Patterson, Adam V, Ding, Ke
Published in Ai zheng (01.02.2014)
Published in Ai zheng (01.02.2014)
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Journal Article
The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach
Ball, Patrick, Thompson, Emma, Anderson, Simon, Gwenin, Vanessa, Ashoorzadeh, Amir, Smaill, Jeff, Gwenin, Chris
Published in Bioscience reports (01.04.2023)
Published in Bioscience reports (01.04.2023)
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Journal Article
The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia
Lock, Richard B., Toscan, Cara E, McCalmont, Hannah, Evans, Kathryn, Doculara, Louise, Kosasih, Hansen J, Gifford, Andrew J, Ashoorzadeh, Amir, Lin, Xiaojing, Trahair, Toby N, De Bock, Charles E, Patterson, Adam V, Smaill, Jeff B
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy
Copp, Janine N., Mowday, Alexandra M., Williams, Elsie M., Guise, Christopher P., Ashoorzadeh, Amir, Sharrock, Abigail V., Flanagan, Jack U., Smaill, Jeff B., Patterson, Adam V., Ackerley, David F.
Published in Cell chemical biology (16.03.2017)
Published in Cell chemical biology (16.03.2017)
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Journal Article
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506
Ashoorzadeh, Amir, Mowday, Alexandra M., Abbattista, Maria R., Guise, Christopher P., Bull, Matthew R., Silva, Shevan, Patterson, Adam V., Smaill, Jeff B.
Published in ACS medicinal chemistry letters (09.11.2023)
Published in ACS medicinal chemistry letters (09.11.2023)
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Journal Article
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506
van der Wiel, Alexander M A, Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M, Lieuwes, Natasja G, Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F, Hicks, Kevin O, Bull, Matthew R, Abbattista, Maria R, Guise, Christopher P, Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J, Balbo, Silvia, Smaill, Jeff B, Theys, Jan, Dubois, Ludwig J, Patterson, Adam V, Lambin, Philippe
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy
Williams, Elsie M, Rich, Michelle H, Mowday, Alexandra M, Ashoorzadeh, Amir, Copp, Janine N, Guise, Christopher P, Anderson, Robert F, Flanagan, Jack U, Smaill, Jeff B, Patterson, Adam V, Ackerley, David F
Published in Biochemistry (Easton) (03.09.2019)
Published in Biochemistry (Easton) (03.09.2019)
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Journal Article
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit
Singleton, Dean C., Mowday, Alexandra M., Guise, Chris P., Syddall, Sophie P., Bai, Sally Y., Li, Dan, Ashoorzadeh, Amir, Smaill, Jeff B., Wilson, William R., Patterson, Adam V.
Published in Cancer gene therapy (01.07.2022)
Published in Cancer gene therapy (01.07.2022)
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Journal Article
Abstract 4959: CP-506, a next generation hypoxia-activated prodrug, as promising novel anti-cancer therapeutic
thiolloy, sophie, Deschoemaeker, Sofie, Ongenae, Nicolas, Gilissen, Julie, Dubois, Ludwig, Yaromina, Ala, Ashoorzadeh, Amir, Smaill, Jeff, Patterson, Adam, Lambin, Philippe, Heyerick, Arne
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Synthesis of new 4-aminobenzoic acid (PABA) hydrazide-hydrazone/sulfonate hybrids and antimicrobial evaluation with ascorbic acid/salicylic acid/N-acetyl cysteine combinations
Han, M. İhsan, İnce, Ufuk, Coşkun, G. Pelin, Birgül, Kaan, Doğan, Şengül Dilem, Ashoorzadeh, Amir, Küçükgüzel, Ş. Güniz
Published in Phosphorus, sulfur, and silicon and the related elements (02.04.2024)
Published in Phosphorus, sulfur, and silicon and the related elements (02.04.2024)
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Journal Article
2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors
Li, Xueqiang, Guise, Christopher P., Taghipouran, Rana, Yosaatmadja, Yuliana, Ashoorzadeh, Amir, Paik, Woo-Kyong, Squire, Christopher J., Jiang, Shuang, Luo, Jinfeng, Xu, Yong, Tu, Zheng-Chao, Lu, Xiaoyun, Ren, Xiaomei, Patterson, Adam V., Smaill, Jeff B., Ding, Ke
Published in European journal of medicinal chemistry (28.07.2017)
Published in European journal of medicinal chemistry (28.07.2017)
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Journal Article
E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications
Mowday, Alexandra Marie, Copp, Janine Naomi, Syddall, Sophie Philippa, Dubois, Ludwig Jerome, Wang, Jingli, Lieuwes, Natasja Gabi, Biemans, Rianne, Ashoorzadeh, Amir, Abbattista, Maria Rosaria, Williams, Elsie May, Guise, Christopher Paul, Lambin, Philippe, Ackerley, David Francis, Smaill, Jeff Bruce, Theys, Jan, Patterson, Adam Vorn
Published in Theranostics (01.01.2020)
Published in Theranostics (01.01.2020)
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Journal Article
Pre-Clinical Activity of Novel Hypoxia-Activated FLT3 Inhibitors in FLT3-Mutated AML
Cavazos, Antonio, Ma, Helen, Benito, Juliana Maria, Levis, Mark J., Daver, Naval, Ashoorzadeh, Amir, Anderson, Robert, Patterson, Adam, Smaill, Jeff, Konopleva, Marina
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411 NTR leading to therapeutic benefit
Singleton, Dean C, Mowday, Alexandra M, Guise, Chris P, Syddall, Sophie P, Bai, Sally Y, Li, Dan, Ashoorzadeh, Amir, Smaill, Jeff B, Wilson, William R, Patterson, Adam V
Published in Cancer gene therapy (01.07.2022)
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Published in Cancer gene therapy (01.07.2022)
Journal Article