Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders
Mikami, Satoshi, Kawasaki, Masanori, Ikeda, Shuhei, Negoro, Nobuyuki, Nakamura, Shinji, Nomura, Izumi, Ashizawa, Tomoko, Kokubo, Hironori, Hoffman, Isaac Dylan, Zou, Hua, Oki, Hideyuki, Uchiyama, Noriko, Hiura, Yuuto, Miyamoto, Maki, Itou, Yuuki, Nakashima, Masato, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Chemical & pharmaceutical bulletin (2017)
Published in Chemical & pharmaceutical bulletin (2017)
Get full text
Journal Article
Extraordinary Effect of Microwave Irradiation on Asymmetric Catalysis
Kikuchi, Satoshi, Tsubo, Tatsuyuki, Ashizawa, Tomoko, Yamada, Tohru
Published in Chemistry letters (05.06.2010)
Published in Chemistry letters (05.06.2010)
Get more information
Journal Article
Enantioselective Henry reaction catalyzed by optically active ketoiminatocobalt complexes
Kogami, Y, Nakajima, T, Ashizawa, T, Kezuka, S, Ikeno, T, Yamada, T
Published in Chemistry letters (05.05.2004)
Published in Chemistry letters (05.05.2004)
Get more information
Journal Article
Discovery of Clinical Candidate N‑((1S)‑1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3‑b]pyrazine-4(1H)‑carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
Mikami, Satoshi, Nakamura, Shinji, Ashizawa, Tomoko, Nomura, Izumi, Kawasaki, Masanori, Sasaki, Shigekazu, Oki, Hideyuki, Kokubo, Hironori, Hoffman, Isaac D, Zou, Hua, Uchiyama, Noriko, Nakashima, Kosuke, Kamiguchi, Naomi, Imada, Haruka, Suzuki, Noriko, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
Get full text
Journal Article
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
SUZUKI, SHINKICHI, IMAEDA, TOSHIHIRO, ASHIZAWA, TOMOKO, OGINO, MASAKI, ARAI, RYOSUKE, KIMURA, EIJI, FUJIMORI, IKUO
Year of Publication 17.12.2015
Get full text
Year of Publication 17.12.2015
Patent
NITROGENATED HETEROCYCLIC COMPOUND
ASHIZAWA TOMOKO, NOMURA IZUMI, NAKAMURA SHINJI, SASAKI SHIGEKAZU, TANIGUCHI TAKAHIKO, KAWASAKI MASANORI, MIKAMI SATOSHI
Year of Publication 15.01.2015
Get full text
Year of Publication 15.01.2015
Patent
Enantioselective 1,3-Dipolar Cycloaddition Reaction of Nitrones with α,β-Unsaturated Aldehydes Catalyzed by Cationic 3-Oxobutylideneaminatocobalt(III) Complexes
Kezuka, Satoko, Ohtsuki, Natsuki, Mita, Tsuyoshi, Kogami, Youichi, Ashizawa, Tomoko, Ikeno, Taketo, Yamada, Tohru
Published in Bulletin of the Chemical Society of Japan (01.11.2003)
Published in Bulletin of the Chemical Society of Japan (01.11.2003)
Get full text
Journal Article
HETEROCYCLIC COMPOUND
NOMURA, IZUMI, KAWASAKI, MASANORI, ASHIZAWA, TOMOKO, NAKAMURA, SHINJI, MIKAMI, SATOSHI, TANIGUCHI, TAKAHIKO
Year of Publication 16.01.2014
Get full text
Year of Publication 16.01.2014
Patent
NITROGENATED HETEROCYCLIC COMPOUND
NOMURA, IZUMI, KAWASAKI, MASANORI, ASHIZAWA, TOMOKO, MIKAMI, SATOSHI, NAKAMURA, SHINJI, TANIGUCHI, TAKAHIKO, SASAKI, SHIGEKAZU
Year of Publication 31.10.2013
Get full text
Year of Publication 31.10.2013
Patent
Enantioselective 1,3-dipolar cycloaddition reactions between nitrones and alpha-substituted alpha,beta-unsaturated aldehydes catalyzed by chiral cationic cobalt(III) complexes
Ohtsuki, N, Kezuka, S, Kogami, Y, Mita, T, Ashizawa, T, Ikeno, T, Yamada, T
Published in Synthesis (Stuttgart) (03.07.2003)
Published in Synthesis (Stuttgart) (03.07.2003)
Get more information
Journal Article
HETEROCYCLIC COMPOUND
MARUI, SHOGO, IMAEDA, TOSHIHIRO, NOMURA, IZUMI, KAWASAKI, MASANORI, SETO, MASAKI, ASHIZAWA, TOMOKO, BANNO, YOSHIHIRO, KAJITA, YUICHI, NAKAMURA, SHINJI, MIKAMI, SATOSHI, TANIGUCHI, TAKAHIKO
Year of Publication 30.04.2015
Get full text
Year of Publication 30.04.2015
Patent
HETEROCYCLIC COMPOUND
IKEDA, SHUHEI, MARUI, SHOGO, NOMURA, IZUMI, IMAEDA, TOSHIHIRO, KAWASAKI, MASANORI, NEGORO, NOBUYUKI, ASHIZAWA, TOMOKO, SETO, MASAKI, MIKAMI, SATOSHI, NAKAMURA, SHINJI, TANIGUCHI, TAKAHIKO, SASAKI, SHIGEKAZU
Year of Publication 29.01.2015
Get full text
Year of Publication 29.01.2015
Patent
NOVEL AMINO ACID DERIVATIVES
Matsuda, Ayumu, Ashizawa, Tomoko, Kobayashi, Yutaka, Kurasaki, Haruaki, Kinebuchi, Masahiko, Murai, Motoki, Matsumoto, Masatoshi, Matsui, Katsuma, Yamada, Masami
Year of Publication 05.10.2023
Get full text
Year of Publication 05.10.2023
Patent
Enantioselective 1,3-Dipolar Cycloaddition Reaction of Nitrones with [alpha],[beta]-Unsaturated Aldehydes Catalyzed by Cationic 3-Oxobutylideneaminatocobalt(III) Complexes
Kezuka, Satoko, Ohtsuki, Natsuki, Mita, Tsuyoshi, Kogami, Youichi, Ashizawa, Tomoko, Ikeno, Taketo, Yamada, Tohru
Published in Bulletin of the Chemical Society of Japan (01.11.2003)
Get full text
Published in Bulletin of the Chemical Society of Japan (01.11.2003)
Journal Article
NITROGENATED HETEROCYCLIC COMPOUND
NOMURA, IZUMI, KAWASAKI, MASANORI, ASHIZAWA, TOMOKO, MIKAMI, SATOSHI, NAKAMURA, SHINJI, TANIGUCHI, TAKAHIKO, SASAKI, SHIGEKAZU
Year of Publication 28.02.2020
Get full text
Year of Publication 28.02.2020
Patent