A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy
Kataoka, Shinsuke, Baba, Atsuyo, Suda, Yoshimitsu, Takii, Ryosuke, Hashimoto, Munetaka, Kawakubo, Tomoyo, Asao, Tetsuji, Kadowaki, Tomoko, Yamamoto, Kenji
Published in The FASEB journal (01.08.2014)
Published in The FASEB journal (01.08.2014)
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Suppression of Pathogenicity of Porphyromonas gingivalis by Newly Developed Gingipain Inhibitors
Kadowaki, Tomoko, Baba, Atsuyo, Abe, Naoko, Takii, Ryosuke, Hashimoto, Munetaka, Tsukuba, Takayuki, Okazaki, Shinji, Suda, Yoshimitsu, Asao, Tetsuji, Yamamoto, Kenji
Published in Molecular pharmacology (01.12.2004)
Published in Molecular pharmacology (01.12.2004)
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Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides
Fukushima, Masakazu, Suzuki, Norihiko, Emura, Tomohiro, Yano, Shingo, Kazuno, Hideki, Tada, Yukio, Yamada, Yuji, Asao, Tetsuji
Published in Biochemical pharmacology (15.05.2000)
Published in Biochemical pharmacology (15.05.2000)
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DNA sequence–selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145
Kiakos, Konstantinos, Sato, Atsushi, Asao, Tetsuji, McHugh, Peter J, Lee, Moses, Hartley, John A
Published in Molecular cancer therapeutics (01.10.2007)
Published in Molecular cancer therapeutics (01.10.2007)
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TAS-108, a Novel Oral Steroidal Antiestrogenic Agent, Is a Pure Antagonist on Estrogen Receptor α and a Partial Agonist on Estrogen Receptor β with Low Uterotrophic Effect
YAMAMOTO, Yasuji, SHIBATA, Jiro, TERADA, Tadafumi, YONEKURA, Kazuhiko, SATO, Kouji, HASHIMOTO, Akihiro, AOYAGI, Yoshimi, WIERZBA, Konstanty, YANO, Shingo, ASAO, Tetsuji, BUZDAR, Aman U
Published in Clinical cancer research (01.01.2005)
Published in Clinical cancer research (01.01.2005)
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Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: Discovery of novel orally active inhibitors of human thymidine phosphorylase
Yano, Shingo, Kazuno, Hideki, Suzuki, Norihiko, Emura, Tomohiro, Wierzba, Konstanty, Yamashita, Jun-ichi, Tada, Yukio, Yamada, Yuji, Fukushima, Masakazu, Asao, Tetsuji
Published in Bioorganic & medicinal chemistry (01.07.2004)
Published in Bioorganic & medicinal chemistry (01.07.2004)
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Inhibition Mechanism of Cathepsin L-Specific Inhibitors Based on the Crystal Structure of Papain–CLIK148 Complex
Tsuge, Hideaki, Nishimura, Tomohiro, Tada, Yukio, Asao, Tetsuji, Turk, Dusan, Turk, Vito, Katunuma, Nobuhiko
Published in Biochemical and biophysical research communications (20.12.1999)
Published in Biochemical and biophysical research communications (20.12.1999)
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Antitumor Activity of a Novel Quinoline Derivative, TAS‐103, with Inhibitory Effects on Topoisomerases I and II
Utsugi, Teruhiro, Aoyagi, Kumio, Asao, Tetsuji, Okazaki, Shinji, Aoyagi, Yoshimi, Sano, Masaki, Wierzba, Konstanty, Yamada, Yuji
Published in Cancer science (01.10.1997)
Published in Cancer science (01.10.1997)
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Nucleosides and nucleotides. Part 212: Practical large-scale synthesis of 1-(3- C-ethynyl-β- d- ribo-pentofuranosyl)cytosine (ECyd), a potent antitumor nucleoside. Isobutyryloxy group as an efficient anomeric leaving group in the Vorbrüggen glycosylation reaction
Nomura, Makoto, Sato, Tsutomu, Washinosu, Masato, Tanaka, Motoaki, Asao, Tetsuji, Shuto, Satoshi, Matsuda, Akira
Published in Tetrahedron (11.02.2002)
Published in Tetrahedron (11.02.2002)
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New Cdc25B Tyrosine Phosphatase Inhibitors, Nocardiones A and B, Produced by Nocardia sp. TP-A0248: Taxonomy, Fermentation, Isolation, Structural Elucidation and Biological Properties
OTANI, TOSHIO, SUGIMOTO, YOSHIKAZU, AOYAGI, YOSHIMI, IGARASHI, YASUHIRO, FURUMAI, TAMOTSU, SAITO, NORIKO, YAMADA, YUJI, ASAO, TETSUJI, OKI, TOSHIKAZU
Published in Journal of antibiotics (01.04.2000)
Published in Journal of antibiotics (01.04.2000)
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Design and Synthesis of Sensitive Fluorogenic Substrates Specific for Lys-Gingipain
Abe, Naoko, Baba, Atsuyo, Kadowaki, Tomoko, Okamoto, Kuniaki, Okazaki, Shinji, Asao, Tetsuji, Yamamoto, Kenji
Published in Journal of biochemistry (Tokyo) (01.11.2000)
Published in Journal of biochemistry (Tokyo) (01.11.2000)
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TAS-301, an Inhibitor of Smooth Muscle Cell Migration and Proliferation, Inhibits Intimal Thickening after Balloon Injury to Rat Carotid Arteries
Muranaka, Y, Yamasaki, Y, Nozawa, Y, Terakawa, H, Tanahashi, Y, Oda, N, Satoh, A, Asao, T, Miyake, H, Matsuura, N
Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)
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New Cdc25B Tyrrosine Phosphatase Inhibitors, Nocardiones A and B, Produced by Nocardia sp. TP-A0248. Taxonomy, Fermentation, Isolation, Structural Elucidation and Biological Prbperties
OTANI, TOSHIO, SUGIMOTO, YOSHIKAZU, AOYAGI, YOSHIMI, IGARASHI, YASUHIRO, FURUMAI, TAMOTSU, SAITO, NORIKO, YAMADA, YUJI, ASAO, TETSUJI, OKI, TOSHIKAZU
Published in Journal of antibiotics (2000)
Published in Journal of antibiotics (2000)
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Efficient Synthesis of Achiral seco-Cyclopropylbenz[2,3-e]indoline Analogues: [4-Amino-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl Chloride and [4-Hydroxy-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl Chloride
SATO, Atsushi, SCOTT, Adrienne, ASAO, Tetsuji, LEE, Moses
Published in Journal of organic chemistry (09.06.2006)
Published in Journal of organic chemistry (09.06.2006)
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A Novel Class of in Vivo Active Anticancer Agents: Achiral seco-Amino- and seco-Hydroxycyclopropylbenz[e]indolone (seco-CBI) Analogues of the Duocarmycins and CC-1065
Sato, Atsushi, McNulty, LuAnne, Cox, Kari, Kim, Susan, Scott, Adrienne, Daniell, Kristen, Summerville, Kaitlin, Price, Carly, Hudson, Stephen, Kiakos, Konstantinos, Hartley, John A, Asao, Tetsuji, Lee, Moses
Published in Journal of medicinal chemistry (02.06.2005)
Published in Journal of medicinal chemistry (02.06.2005)
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Efficient Synthesis of Achiral s eco-Cyclopropylbenz[2,3-e]indoline Analogues: [4-Amino-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl Chloride and [4-Hydroxy-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl Chloride
Sato, Atsushi, Scott, Adrienne, Asao, Tetsuji, Lee, Moses
Published in Journal of organic chemistry (09.06.2006)
Published in Journal of organic chemistry (09.06.2006)
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Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: Optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase
Yano, Shingo, Kazuno, Hideki, Sato, Tsutomu, Suzuki, Norihiko, Emura, Tomohiro, Wierzba, Konstanty, Yamashita, Jun-ichi, Tada, Yukio, Yamada, Yuji, Fukushima, Masakazu, Asao, Tetsuji
Published in Bioorganic & medicinal chemistry (01.07.2004)
Published in Bioorganic & medicinal chemistry (01.07.2004)
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DNA interstrand crosslinking agents: Synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD)
Purnell, Bethany, Sato, Atsushi, O’Kelley, Amanda, Price, Carly, Summerville, Kaitlin, Hudson, Stephen, O’Hare, Caroline, Kiakos, Konstantinos, Asao, Tetsuji, Lee, Moses, Hartley, John A.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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