Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β
Arndt, Joseph W., Qian, Fang, Smith, Benjamin A., Quan, Chao, Kilambi, Krishna Praneeth, Bush, Martin W., Walz, Thomas, Pepinsky, R. Blake, Bussière, Thierry, Hamann, Stefan, Cameron, Thomas O., Weinreb, Paul H.
Published in Scientific reports (23.04.2018)
Published in Scientific reports (23.04.2018)
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Journal Article
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
Weihofen, Andreas, Liu, YuTing, Arndt, Joseph W., Huy, Christian, Quan, Chao, Smith, Benjamin A., Baeriswyl, Jean-Luc, Cavegn, Nicole, Senn, Luzia, Su, Lihe, Marsh, Galina, Auluck, Pavan K., Montrasio, Fabio, Nitsch, Roger M., Hirst, Warren D., Cedarbaum, Jesse M., Pepinsky, R. Blake, Grimm, Jan, Weinreb, Paul H.
Published in Neurobiology of disease (01.04.2019)
Published in Neurobiology of disease (01.04.2019)
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Journal Article
Heat Shock Protein 90: Inhibitors in Clinical Trials
Biamonte, Marco A, Van de Water, Ryan, Arndt, Joseph W, Scannevin, Robert H, Perret, Daniel, Lee, Wen-Cherng
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Journal Article
Characterization of tau binding by gosuranemab
Sopko, Richelle, Golonzhka, Olga, Arndt, Joseph, Quan, Chao, Czerkowicz, Julie, Cameron, Andrew, Smith, Benjamin, Murugesan, Yogapriya, Gibbons, Garrett, Kim, Soo-Jung, Trojanowski, John Q., Lee, Virginia M.Y., Brunden, Kurt R., Graham, Danielle L., Weinreb, Paul H., Hering, Heike
Published in Neurobiology of disease (01.12.2020)
Published in Neurobiology of disease (01.12.2020)
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Journal Article
Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Tepp, William H, Arndt, Joseph W, Chapman, Edwin R, Chai, Qing, Johnson, Eric A, Stevens, Raymond C, Dong, Min
Published in Nature (21.12.2006)
Published in Nature (21.12.2006)
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Journal Article
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site
Hanf, Karl J M, Arndt, Joseph W, Liu, YuTing, Gong, Bang Jian, Rushe, Mia, Sopko, Richelle, Massol, Ramiro, Smith, Benjamin, Gao, Yan, Dalkilic-Liddle, Isin, Lee, Xinhua, Mojta, Shanell, Shao, Zhaohui, Mi, Sha, Pepinsky, R Blake
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Journal Article
Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin
Marks, James D, Garcia-Rodriguez, Consuelo, Levy, Raphael, Arndt, Joseph W, Forsyth, Charles M, Razai, Ali, Lou, Jianlong, Geren, Isin, Stevens, Raymond C
Published in Nature biotechnology (01.01.2007)
Published in Nature biotechnology (01.01.2007)
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Journal Article
Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy
Pepinsky, R Blake, Arndt, Joseph W, Quan, Chao, Gao, Yan, Quintero-Monzon, Omar, Lee, Xinhua, Mi, Sha
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
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Journal Article
EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity
Yun, Theodore J, Harning, Erin K, Giza, Keith, Rabah, Dania, Li, Ping, Arndt, Joseph W, Luchetti, David, Biamonte, Marco A, Shi, Jiandong, Lundgren, Karen, Manning, Anthony, Kehry, Marilyn R
Published in The Journal of immunology (1950) (01.01.2011)
Published in The Journal of immunology (1950) (01.01.2011)
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Journal Article
A Structural Perspective of the Sequence Variability Within Botulinum Neurotoxin Subtypes A1-A4
Arndt, Joseph W., Jacobson, Mark J., Abola, Enrique E., Forsyth, Charles M., Tepp, William H., Marks, James D., Johnson, Eric A., Stevens, Raymond C.
Published in Journal of molecular biology (29.09.2006)
Published in Journal of molecular biology (29.09.2006)
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Journal Article
STRUCTURAL BASIS OF UNIQUE SELECTIVITY OF ADUCANUMAB FOR OLIGOMERIC FORMS OF AMYLOID-β
Arndt, Joseph W, Quan, Chao, Qian, Fang, Kilambi, Krishna Praneeth, Bussière, Thierry, Weinreb, Paul
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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Journal Article
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
Erlanson, Daniel A., Arndt, Joseph W., Cancilla, Mark T., Cao, Kathy, Elling, Robert A., English, Nicki, Friedman, Jessica, Hansen, Stig K., Hession, Cathy, Joseph, Ingrid, Kumaravel, Gnanasambandam, Lee, Wen-Cherng, Lind, Ken E., McDowell, Robert S., Miatkowski, Konrad, Nguyen, Christine, Nguyen, Thinh B., Park, Sophia, Pathan, Nuzhat, Penny, David M., Romanowski, Michael J., Scott, Daniel, Silvian, Laura, Simmons, Robert L., Tangonan, Bradley T., Yang, Wenjin, Sun, Lihong
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Journal Article
EC144 Is a Potent Inhibitor of the Heat Shock Protein 90
Shi, Jiandong, Van de Water, Ryan, Hong, Kevin, Lamer, Ryan B, Weichert, Kenneth W, Sandoval, Cristina M, Kasibhatla, Srinivas R, Boehm, Marcus F, Chao, Jianhua, Lundgren, Karen, Timple, Noelito, Lough, Rachel, Ibanez, Gerardo, Boykin, Christina, Burrows, Francis J, Kehry, Marilyn R, Yun, Theodore J, Harning, Erin K, Ambrose, Christine, Thompson, Jeffrey, Bixler, Sarah A, Dunah, Anthone, Snodgrass-Belt, Pamela, Arndt, Joseph, Enyedy, Istvan J, Li, Ping, Hong, Victor S, McKenzie, Andres, Biamonte, Marco A
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework
Hanf, Karl J.M., Arndt, Joseph W., Chen, Ling Ling, Jarpe, Matthew, Boriack-Sjodin, P. Ann, Li, You, van Vlijmen, Herman W.T., Pepinsky, R. Blake, Simon, Kenneth J., Lugovskoy, Alexey
Published in Methods (San Diego, Calif.) (01.01.2014)
Published in Methods (San Diego, Calif.) (01.01.2014)
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Journal Article
Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Jordan, Jacob L., Arndt, Joseph W., Hanf, Karl, Li, Guohui, Hall, Janine, Demarest, Stephen, Huang, Flora, Wu, Xiufeng, Miller, Brian, Glaser, Scott, Fernandez, Erik J., Wang, Deping, Lugovskoy, Alexey
Published in Proteins, structure, function, and bioinformatics (01.12.2009)
Published in Proteins, structure, function, and bioinformatics (01.12.2009)
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Journal Article
Engineering potent long-acting variants of the Wnt inhibitor DKK2
Sopko, Richelle, Mugford, Joshua W., Lehmann, Andreas, Shapiro, Renée I., Rushe, Mia, Kulkarni, Abhishek, Worrall, Joseph, Amatucci, Joseph, Wen, Dingyi, Pederson, Nels E., Minesinger, Brenda K., Arndt, Joseph W., Pepinsky, Blake
Published in Protein engineering, design and selection (01.05.2017)
Published in Protein engineering, design and selection (01.05.2017)
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Journal Article
Crystal Structure of Botulinum Neurotoxin Type G Light Chain: Serotype Divergence in Substrate Recognition
Arndt, Joseph W, Yu, Wayne, Bi, Fay, Stevens, Raymond C
Published in Biochemistry (Easton) (19.07.2005)
Published in Biochemistry (Easton) (19.07.2005)
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Journal Article