Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)
Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank
Published in Journal of medicinal chemistry (23.07.2009)
Published in Journal of medicinal chemistry (23.07.2009)
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Journal Article
The Small Molecule Hesperadin Reveals a Role for Aurora B in Correcting Kinetochore-Microtubule Attachment and in Maintaining the Spindle Assembly Checkpoint
Hauf, Silke, Cole, Richard W., LaTerra, Sabrina, Zimmer, Christine, Schnapp, Gisela, Walter, Rainer, Heckel, Armin, van Meel, Jacques, Rieder, Conly L., Peters, Jan-Michael
Published in The Journal of cell biology (28.04.2003)
Published in The Journal of cell biology (28.04.2003)
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Journal Article
Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization
Baum, Patrick, Schmid, Ramona, Ittrich, Carina, Rust, Werner, Fundel-Clemens, Katrin, Siewert, Susanne, Baur, Martin, Mara, Lisa, Gruenbaum, Lore, Heckel, Armin, Eils, Roland, Kontermann, Roland E, Roth, Gerald J, Gantner, Florian, Schnapp, Andreas, Park, John E, Weith, Andreas, Quast, Karsten, Mennerich, Detlev
Published in PloS one (10.12.2010)
Published in PloS one (10.12.2010)
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Journal Article
Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis
Betzemeier, Bodo, Braun, Clemens, Sieger, Peter, Heckel, Armin, Linz, Günter, Linehan, Brian, Veser, Thomas, Wiedenmayer, Dieter, Kley, Jörg T.
Published in European journal of medicinal chemistry (05.02.2024)
Published in European journal of medicinal chemistry (05.02.2024)
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Journal Article
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
Hilberg, Frank, Roth, Gerald J, Krssak, Martin, Kautschitsch, Susanna, Sommergruber, Wolfgang, Tontsch-Grunt, Ulrike, Garin-Chesa, Pilar, Bader, Gerd, Zoephel, Andreas, Quant, Jens, Heckel, Armin, Rettig, Wolfgang J
Published in Cancer research (Chicago, Ill.) (15.06.2008)
Published in Cancer research (Chicago, Ill.) (15.06.2008)
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Journal Article
Crystal Structure of Glucokinase Regulatory Protein
Pautsch, Alexander, Stadler, Nadja, Löhle, Adelheid, Rist, Wolfgang, Berg, Adina, Glocker, Lucia, Nar, Herbert, Reinert, Dirk, Lenter, Martin, Heckel, Armin, Schnapp, Gisela, Kauschke, Stefan G
Published in Biochemistry (Easton) (21.05.2013)
Published in Biochemistry (Easton) (21.05.2013)
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Journal Article
6,6-Disubstituted hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors
Soyka, Rainer, Heckel, Armin, Nickl, Josef, Eisert, Wolfgang, Mueller, Thomas H, Weisenberger, Hans
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Journal Article
Design, Synthesis, and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor β Receptor I (TGFβRI)
Roth, Gerald J, Heckel, Armin, Brandl, Trixi, Grauert, Matthias, Hoerer, Stefan, Kley, Joerg T, Schnapp, Gisela, Baum, Patrick, Mennerich, Detlev, Schnapp, Andreas, Park, John E
Published in Journal of medicinal chemistry (28.10.2010)
Published in Journal of medicinal chemistry (28.10.2010)
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Journal Article
Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908
Oost, Thorsten, Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Journal Article
Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition
Roth, Gerald J., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan G., Oost, Thorsten, Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Schindler, Marcus, Thomas, Leo, Stenkamp, Dirk
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
Published in Bioorganic & medicinal chemistry letters (15.08.2015)
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Journal Article
Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction
Weishaupt, Jochen H, Kussmaul, Lothar, Grötsch, Philipp, Heckel, Armin, Rohde, G, Romig, H, Bähr, Mathias, Gillardon, Frank
Published in Molecular and cellular neuroscience (01.10.2003)
Published in Molecular and cellular neuroscience (01.10.2003)
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Journal Article
ARYL-AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANS AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE
FRANK HIMMELSBACH, ARMIN HECKEL, ANNETTE SCHULER-METZ, STEFAN PETERS, THORSTEN LEHMANN-LINTZ, HERBERT NAR, BRADFORD S HAMILTON, JOERG KLEY, MATTHIAS ZENTGRAF, MATTHIAS ECKHARDT
Year of Publication 12.11.2015
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Year of Publication 12.11.2015
Patent
TRIAZOLE BENZAMIDE DERIVATIVES AS GPR142 AGONISTS
HECKEL, Armin, AUGUSTIN, Robert, FRATTINI, Sara, WELLENZOHN, Bernd, BANDHOLTZ, Sebastian
Year of Publication 03.04.2024
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Year of Publication 03.04.2024
Patent
MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
HECKEL, Armin, CHAUDHARY, Nveed, DAHMANN, Georg, ROTH, Gerald Juergen, BRANDL, Trixi, GRAUERT, Matthias, PARK, John Edward
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent