High-Throughput Screening: today’s biochemical and cell-based approaches
Blay, Vincent, Tolani, Bhairavi, Ho, Sunita P., Arkin, Michelle R.
Published in Drug discovery today (01.10.2020)
Published in Drug discovery today (01.10.2020)
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Pharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter
Published in eLife (28.05.2013)
Published in eLife (28.05.2013)
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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
Debnath, Anjan, Parsonage, Derek, Andrade, Rosa M, He, Chen, Cobo, Eduardo R, Hirata, Ken, Chen, Steven, García-Rivera, Guillermina, Orozco, Esther, Martínez, Máximo B, Gunatilleke, Shamila S, Barrios, Amy M, Arkin, Michelle R, Poole, Leslie B, McKerrow, James H, Reed, Sharon L
Published in Nature medicine (01.06.2012)
Published in Nature medicine (01.06.2012)
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Journal Article
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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Journal Article
A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit
De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H
Published in PLoS neglected tropical diseases (01.07.2011)
Published in PLoS neglected tropical diseases (01.07.2011)
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Journal Article
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1
Rettenmaier, T. Justin, Sadowsky, Jack D., Thomsen, Nathan D., Chen, Steven C., Doak, Allison K., Arkin, Michelle R., Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
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Journal Article
Altered cofactor regulation with disease-associated p97/VCP mutations
Zhang, Xiaoyi, Gui, Lin, Zhang, Xiaoyan, Bulfer, Stacie L., Sanghez, Valentina, Wong, Daniel E., Lee, YouJin, Lehmann, Lynn, Lee, James Siho, Shih, Pei-Yin, Lin, Henry J., Iacovino, Michelina, Weihl, Conrad C., Arkin, Michelle R., Wang, Yanzhuang, Chou, Tsui-Fen
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
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Journal Article
Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia
Pariury, Holly, Fandel, Joshua, Bachl, Stefanie, Ang, Kenny K, Markossian, Sarine, Wilson, Chris G, Braun, Benjamin S, Popescu, Bogdan, Wohlfeil, Margo, Beckman, Kyle, Xirenayi, Simayijiang, Roy, Ritu P, Olshen, Adam B, Smith, Catherine, Arkin, Michelle R, Loh, Mignon L, Diaz-Flores, Ernesto
Published in Haematologica (Roma) (01.05.2023)
Published in Haematologica (Roma) (01.05.2023)
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A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons
Kim, Gha-Hyun J, Mo, Han, Liu, Harrison, Wu, Zhihao, Chen, Steven, Zheng, Jiashun, Zhao, Xiang, Nucum, Daryl, Shortland, James, Peng, Longping, Elepano, Mannuel, Tang, Benjamin, Olson, Steven, Paras, Nick, Li, Hao, Renslo, Adam R, Arkin, Michelle R, Huang, Bo, Lu, Bingwei, Sirota, Marina, Guo, Su
Published in eLife (22.09.2021)
Published in eLife (22.09.2021)
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A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels
Bagriantsev, Sviatoslav N, Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A, Arkin, Michelle R, Renslo, Adam R, Minor, Daniel L
Published in ACS chemical biology (16.08.2013)
Published in ACS chemical biology (16.08.2013)
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Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease
Engel, Juan C, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, McKerrow, James H, Doyle, Patricia S
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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Journal Article
Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening
Sanchez, Mateo I, de Vries, Laura E, Lehmann, Christine, Lee, Jeong T, Ang, Kenny K, Wilson, Christopher, Chen, Steven, Arkin, Michelle R, Bogyo, Matthew, Deu, Edgar
Published in PloS one (18.12.2019)
Published in PloS one (18.12.2019)
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Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues
Vickery, Holly R., Virta, Johanna M., Konstantinidou, Markella, Arkin, Michelle R.
Published in SLAS discovery (01.07.2024)
Published in SLAS discovery (01.07.2024)
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Journal Article
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II
Hawtin, Rachael E, Stockett, David E, Byl, Jo Ann W, McDowell, Robert S, Nguyen, Tan, Arkin, Michelle R, Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A
Published in PloS one (15.04.2010)
Published in PloS one (15.04.2010)
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Journal Article
Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease
Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek
Published in PLoS pathogens (01.07.2015)
Published in PLoS pathogens (01.07.2015)
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