Antitumor Activity of the Selective Pan-RAF Inhibitor TAK-632 in BRAF Inhibitor-Resistant Melanoma
NAKAMURA, Akito, ARITA, Takeo, TSUCHIYA, Shuntarou, DONELAN, Jill, CHOUITAR, Jouhara, CARIDEO, Elizabeth, GALVIN, Katherine, OKANIWA, Masanori, ISHIKAWA, Tomoyasu, YOSHIDA, Sei
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Shitara, Kohei, Bang, Yung-Jue, Iwasa, Satoru, Sugimoto, Naotoshi, Ryu, Min-Hee, Sakai, Daisuke, Chung, Hyun Cheol, Kawakami, Hisato, Yabusaki, Hiroshi, Sakamoto, Yasuhiro, Nishina, Tomohiro, Inaki, Koichiro, Kuwahara, Yusuke, Wada, Naoya, Suto, Fumitaka, Arita, Takeo, Sugihara, Masahiro, Tsuchihashi, Zenta, Saito, Kaku, Kojima, Akihito, Yamaguchi, Kensei
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Published in Nature medicine (01.07.2024)
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Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C‑7-Substituted 1,3-Benzothiazole Derivatives
Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation
Arita, Takeo, Morimoto, Megumi, Yamamoto, Yukiko, Miyashita, Hitoshi, Kitazawa, Satoshi, Hirayama, Takaharu, Sakamoto, Sou, Miyamoto, Kazumasa, Adachi, Ryutaro, Iwatani, Misa, Hara, Takahito
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Published in Biochemical and biophysical research communications (08.07.2017)
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Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors
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Published in Bioorganic & medicinal chemistry (01.06.2016)
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Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds
Okaniwa, Masanori, Hirose, Masaaki, Imada, Takashi, Ohashi, Tomohiro, Hayashi, Youko, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Kakoi, Kazuyo, Kato, Juran, Takagi, Terufumi, Kawamoto, Tomohiro, Yao, Shuhei, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Oki, Hideyuki, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Abstract 4247: Characterization of the selective pan-RAF inhibitor TAK-632 with antitumor activity in BRAF inhibitor-resistant melanoma
Nakamura, Akito, Arita, Takeo, Tsuchiya, Shuntarou, Donelan, Jill, Chouitar, Jouhara, Carideo, Elizabeth, Galvin, Katherine, Okaniwa, Masanori, Ishikawa, Tomoyasu, Yoshida, Sei
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives
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Published in Bioorganic & medicinal chemistry (15.09.2012)
Published in Bioorganic & medicinal chemistry (15.09.2012)
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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption
Okaniwa, Masanori, Imada, Takashi, Ohashi, Tomohiro, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Sumita, Akihiko, Tsutsumi, Shunichirou, Higashikawa, Keiko, Takagi, Terufumi, Kawamoto, Tomohiro, Inui, Yoshitaka, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (01.08.2012)
Published in Bioorganic & medicinal chemistry (01.08.2012)
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Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas
Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC
Cunniff, Elizabeth Grace Carideo, Zhang, Julie, Chouitar, Jouhara, Mettetal, Jerome, Nakamura, Kazuhide, Arita, Takeo, Nakamura, Akito, Okaniwa, Masanori, Ishikawa, Tomoyasu, Yoshida, Sei, Fabrey, Robyn, Vincent, Patrick, Eng, Kurt, Garcia, Khristofer, Borrelli, Deanna, Vagrhese, Teena, Stroud, Steve, Menon, Saurabh, Kuranda, Mike, Galvin, Katherine
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of melanoma and CRC
Cunniff, Elizabeth Grace Carideo, Zhang, Julie, Chouitar, Jouhara, Mettetal, Jerome, Nakamura, Kazuhide, Arita, Takeo, Nakamura, Akito, Okaniwa, Masanori, Ishikawa, Tomoyasu, Yoshida, Sei, Fabrey, Robyn, Vincent, Patrick, Eng, Kurt, Garcia, Khristofer, Borelli, Deanna, Vagrhese, Teena, Stroud, Steve, Menon, Saurabh, Kuranda, Mike, Galvin, Katherine
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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