Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
Nagata, Tetsuya, Dwyer, Chrissa A., Yoshida-Tanaka, Kie, Ihara, Kensuke, Ohyagi, Masaki, Kaburagi, Hidetoshi, Miyata, Haruka, Ebihara, Satoe, Yoshioka, Kotaro, Ishii, Takashi, Miyata, Kanjiro, Miyata, Kenichi, Powers, Berit, Igari, Tomoko, Yamamoto, Syunsuke, Arimura, Naoto, Hirabayashi, Hideki, Uchihara, Toshiki, Hara, Rintaro Iwata, Wada, Takeshi, Bennett, C. Frank, Seth, Punit P., Rigo, Frank, Yokota, Takanori
Published in Nature biotechnology (01.12.2021)
Published in Nature biotechnology (01.12.2021)
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Journal Article
Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors
Aida, Jumpei, Fushimi, Makoto, Kusumoto, Tomokazu, Sugiyama, Hideyuki, Arimura, Naoto, Ikeda, Shuhei, Sasaki, Masako, Sogabe, Satoshi, Aoyama, Kazunobu, Koike, Tatsuki
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
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Journal Article
Design, Synthesis, and Evaluation of (4R)‑1-{3-[2‑(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T‑401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase
Hattori, Yasushi, Aoyama, Kazunobu, Maeda, Jun, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Fujinaga, Masayuki, Seki, Chie, Nagai, Yuji, Kawamura, Kazunori, Yamasaki, Tomoteru, Zhang, Ming-Rong, Higuchi, Makoto, Koike, Tatsuki
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
Miyakawa, Shuuichi, Sakuma, Hiroyuki, Warude, Dnyaneshwar, Asanuma, Satomi, Arimura, Naoto, Yoshihara, Tomoki, Tavares, Daniel, Hata, Akito, Ida, Koh, Hori, Yuri, Okuzono, Yuumi, Yamamoto, Syunsuke, Iida, Koichi, Shimizu, Hisao, Kondo, Shinichi, Sato, Shuji
Published in Frontiers in neuroscience (15.12.2020)
Published in Frontiers in neuroscience (15.12.2020)
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Journal Article
Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation
Takahashi, Yu, Shinoda, Akihiro, Furuya, Norihiko, Harada, Eri, Arimura, Naoto, Ichi, Ikuyo, Fujiwara, Yoko, Inoue, Jun, Sato, Ryuichiro
Published in PloS one (29.05.2013)
Published in PloS one (29.05.2013)
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Journal Article
Sterol Regulatory Element-binding Protein-2 Interacts with Hepatocyte Nuclear Factor-4 to Enhance Sterol Isomerase Gene Expression in Hepatocytes
Misawa, Koichi, Horiba, Taro, Arimura, Naoto, Hirano, Yuko, Inoue, Jun, Emoto, Noriaki, Shimano, Hitoshi, Shimizu, Makoto, Sato, Ryuichiro
Published in The Journal of biological chemistry (19.09.2003)
Published in The Journal of biological chemistry (19.09.2003)
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Journal Article
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety
Ikeda, Shuhei, Sugiyama, Hideyuki, Tokuhara, Hidekazu, Murakami, Masataka, Nakamura, Minoru, Oguro, Yuya, Aida, Jumpei, Morishita, Nao, Sogabe, Satoshi, Dougan, Douglas R., Gay, Sean C., Qin, Ling, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Kamada, Yusuke, Aoyama, Kazunobu, Kimoto, Kouya, Kamata, Makoto
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2H‑benzo[b][1,4]oxazin-6-yl Moiety
Ikeda, Shuhei, Sugiyama, Hideyuki, Tokuhara, Hidekazu, Murakami, Masataka, Nakamura, Minoru, Oguro, Yuya, Aida, Jumpei, Morishita, Nao, Sogabe, Satoshi, Dougan, Douglas R., Gay, Sean C., Qin, Ling, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Kamada, Yusuke, Aoyama, Kazunobu, Kimoto, Kouya, Kamata, Makoto
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway
Ikeda, Zenichi, Kamei, Taku, Sasaki, Yusuke, Reynolds, Matthew, Sakai, Nozomu, Yoshikawa, Masato, Tawada, Michiko, Morishita, Nao, Dougan, Douglas R., Chen, Chien-Hung, Levin, Irena, Zou, Hua, Kuno, Masako, Arimura, Naoto, Kikukawa, Yusuke, Kondo, Mitsuyo, Tohyama, Kimio, Sato, Kenjiro
Published in Journal of medicinal chemistry (11.05.2023)
Published in Journal of medicinal chemistry (11.05.2023)
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Journal Article
BBB-PASSING LIPID LIGAND OF HETERO NUCLEIC ACID
ADACHI YUSUKE, YOKOTA TAKANORI, FURUKAWA HIDEKI, HIDAKA KOSUKE, ARIMURA NAOTO, TOKUNO RYOSUKE, MIYATA KENICHI, SASAKI SHIGEKAZU, YOGO YOSHINORI, SEKI MICHIHIRO, NAKAGAWA YASUO, NAGATA TETSUYA
Year of Publication 08.06.2023
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Year of Publication 08.06.2023
Patent
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides
Rikimaru, Kentaro, Wakabayashi, Takeshi, Abe, Hidenori, Imoto, Hiroshi, Maekawa, Tsuyoshi, Ujikawa, Osamu, Murase, Katsuhito, Matsuo, Takanori, Matsumoto, Mitsuharu, Nomura, Chisako, Tsuge, Hiroko, Arimura, Naoto, Kawakami, Kazutoshi, Sakamoto, Junichi, Funami, Miyuki, Mol, Clifford D., Snell, Gyorgy P., Bragstad, Kenneth A., Sang, Bi-Ching, Dougan, Douglas R., Tanaka, Toshimasa, Katayama, Nozomi, Horiguchi, Yoshiaki, Momose, Yu
Published in Bioorganic & medicinal chemistry (15.01.2012)
Published in Bioorganic & medicinal chemistry (15.01.2012)
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Journal Article
BBB-PASSING LIPID LIGAND OF HETERO NUCLEIC ACID
SASAKI Shigekazu, SEKI Tomohiro, MIYATA Kenichi, TOKUNOH Ryosuke, NAGATA Tetsuya, ADACHI Yusuke, YOKOTA Takanori, HIDAKA Kosuke, FURUKAWA Hideki, NAKAGAWA Yasuo, YOGO Takatoshi, ARIMURA Naoto
Year of Publication 26.09.2019
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Year of Publication 26.09.2019
Patent
Structure–activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists
Rikimaru, Kentaro, Wakabayashi, Takeshi, Abe, Hidenori, Tawaraishi, Taisuke, Imoto, Hiroshi, Yonemori, Jinichi, Hirose, Hideki, Murase, Katsuhito, Matsuo, Takanori, Matsumoto, Mitsuharu, Nomura, Chisako, Tsuge, Hiroko, Arimura, Naoto, Kawakami, Kazutoshi, Sakamoto, Junichi, Funami, Miyuki, Mol, Clifford D., Snell, Gyorgy P., Bragstad, Kenneth A., Sang, Bi-Ching, Dougan, Douglas R., Tanaka, Toshimasa, Katayama, Nozomi, Horiguchi, Yoshiaki, Momose, Yu
Published in Bioorganic & medicinal chemistry (15.05.2012)
Published in Bioorganic & medicinal chemistry (15.05.2012)
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A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides: Symposium-in-Print: Chemical Proteomics
RIKIMARU, Kentaro, WAKABAYASHI, Takeshi, TSUGE, Hiroko, ARIMURA, Naoto, KAWAKAMI, Kazutoshi, SAKAMOTO, Junichi, FUNAMI, Miyuki, MOL, Clifford D, SNELL, Gyorgy P, BRAGSTAD, Kenneth A, SANG, Bi-Ching, DOUGAN, Douglas R, ABE, Hidenori, TANAKA, Toshimasa, KATAYAMA, Nozomi, HORIGUCHI, Yoshiaki, MOMOSE, Yu, IMOTO, Hiroshi, MAEKAWA, Tsuyoshi, UJIKAWA, Osamu, MURASE, Katsuhito, MATSUO, Takanori, MATSUMOTO, Mitsuharu, NOMURA, Chisako
Published in Bioorganic & medicinal chemistry (2012)
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Published in Bioorganic & medicinal chemistry (2012)
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BBB-PASSING LIPID LIGAND OF HETERO NUCLEIC ACID
ARIMURA, Naoto, FURUKAWA, Hideki, SASAKI, Shigekazu, YOGO, Takatoshi, NAKAGAWA, Yasuo, TOKUNOH, Ryosuke, ADACHI, Yusuke, NAGATA, Tetsuya, SEKI, Tomohiro, MIYATA, Kenichi, HIDAKA, Kosuke, YOKOTA, Takanori
Year of Publication 09.03.2022
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Year of Publication 09.03.2022
Patent
BBB-PASSING LIPID LIGAND OF HETERO NUCLEIC ACID
ARIMURA, Naoto, FURUKAWA, Hideki, SASAKI, Shigekazu, YOGO, Takatoshi, NAKAGAWA, Yasuo, TOKUNOH, Ryosuke, ADACHI, Yusuke, NAGATA, Tetsuya, SEKI, Tomohiro, MIYATA, Kenichi, HIDAKA, Kosuke, YOKOTA, Takanori
Year of Publication 03.06.2021
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Year of Publication 03.06.2021
Patent
BBB-PASSING LIPID LIGAND OF HETERO NUCLEIC ACID
ARIMURA, Naoto, FURUKAWA, Hideki, SASAKI, Shigekazu, YOGO, Takatoshi, NAKAGAWA, Yasuo, TOKUNOH, Ryosuke, ADACHI, Yusuke, NAGATA, Tetsuya, SEKI, Tomohiro, MIYATA, Kenichi, HIDAKA, Kosuke, YOKOTA, Takanori
Year of Publication 27.01.2021
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Year of Publication 27.01.2021
Patent