A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay
SMITH, Emilie D, ARIANE VINSON, N, DESONG ZHONG, BERRANG, Bertold D, CATANZARO, Jennifer L, THOMAS, James B, NAVARRO, Hernan A, GILMOUR, Brian P, DESCHAMPS, Jeffrey, CARROLL, F. Ivy
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist
Thomas, James B, Atkinson, Robert N, Vinson, N. Ariane, Catanzaro, Jennifer L, Perretta, Carin L, Fix, Scott E, Mascarella, S. Wayne, Rothman, Richard B, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity
Thomas, James B, Atkinson, Robert N, Rothman, Richard B, Fix, Scott E, Mascarella, S. Wayne, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Lu, Y. -F, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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A new synthesis of the ORL-1 antagonist 1-[(3 R,4 R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2 H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay
Smith, Emilie D., Ariane Vinson, N., Zhong, Desong, Berrang, Bertold D., Catanzaro, Jennifer L., Thomas, James B., Navarro, Hernán A., Gilmour, Brian P., Deschamps, Jeffrey, Carroll, F. Ivy
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans
Thomas, James B, Atkinson, Robert N, Namdev, Nivedita, Rothman, Richard B, Gigstad, Kenneth M, Fix, Scott E, Mascarella, S. Wayne, Burgess, Jason P, Vinson, N. Ariane, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F. Ivy
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist
Thomas, James B, Atkinson, Robert N, Vinson, N Ariane, Catanzaro, Jennifer L, Perretta, Carin L, Fix, Scott E, Mascarella, S Wayne, Rothman, Richard B, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F Ivy
Published in Journal of medicinal chemistry (03.07.2003)
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Published in Journal of medicinal chemistry (03.07.2003)
Journal Article
Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidiny l]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide as a novel potent and selective opioid K receptor antagonist
THOMAS, James B, ATKINSON, Robert N, CANTRELL, Buddy E, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, VINSON, N. Ariane, CATANZARO, Jennifer L, PERRETTA, Carin L, FIX, Scott E, MASCARELLA, S. Wayne, ROTHMAN, Richard B, HENG XU, DERSCH, Christina M
Published in Journal of medicinal chemistry (2003)
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Published in Journal of medicinal chemistry (2003)
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Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans
Thomas, James B, Atkinson, Robert N, Namdev, Nivedita, Rothman, Richard B, Gigstad, Kenneth M, Fix, Scott E, Mascarella, S Wayne, Burgess, Jason P, Vinson, N Ariane, Xu, Heng, Dersch, Christina M, Cantrell, Buddy E, Zimmerman, Dennis M, Carroll, F Ivy
Published in Journal of medicinal chemistry (01.08.2002)
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Published in Journal of medicinal chemistry (01.08.2002)
Journal Article
Identification of the first trans-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid k receptor antagonist activity
THOMAS, James B, ATKINSON, Robert N, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, ROTHMAN, Richard B, FIX, Scott E, MASCARELLA, S. Wayne, VINSON, N. Ariane, HENG XU, DERSCH, Christina M, LU, Y.-F, CANTRELL, Buddy E
Published in Journal of medicinal chemistry (2001)
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Published in Journal of medicinal chemistry (2001)
Journal Article
Discovery of an opioid κK receptor selective pure antagonist from a library of N-substituted 4β-methyl-5-(3-hydroxyphenyl)morphans
THOMAS, James B, ATKINSON, Robert N, DERSCH, Christina M, CANTRELL, Buddy E, ZIMMERMAN, Dennis M, CARROLL, F. Ivy, NAMDEV, Nivedita, ROTHMAN, Richard B, GIGSTAD, Kenneth M, FIX, Scott E, MASCARELLA, S. Wayne, BURGESS, Jason P, VINSON, N. Ariane, HENG XU
Published in Journal of medicinal chemistry (2002)
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Published in Journal of medicinal chemistry (2002)
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General Preparation of Cyclopentadienyl Molybdenum Dicarbonyl η3-2-Alkylidene Cyclobutanonyl Complexes
Vinson, N. Ariane, Day, Cynthia S, Welker, Mark E, Guzei, Ilia, Rheingold, Arnold L
Published in Organometallics (10.05.1999)
Published in Organometallics (10.05.1999)
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