Search Results - "ARFSTEN, Ann E" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (15.04.2009)

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 3: Design, synthesis and sar of orally bioavailable benzamidine-P4 inhibitors

by JIA, Zhaozhong J, YANHONG WU, HOLLENNBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, YONGHONG SONG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, HUTCHALEELAHA, Athiwat
Published in Bioorganic & medicinal chemistry letters (08.03.2004)

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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs

by JIA, Zhaozhong J, YANHONG WU, HUTCHALEELAHA, Athiwat, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, CLIZBE, Lane A, GOLDMAN, Erick A, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, ALPHONSO, Merlyn
Published in Bioorganic & medicinal chemistry letters (08.03.2004)

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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors

by JIA, Zhaozhong J, TING SU, WENRONG HUANG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, HUTCHALEELAHA, Athiwat, HOLLENBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, YANHONG WU, GOLDMAN, Erick A, WENHAO LI, PENGLIE ZHANG, CLIZBE, Lane A, YONGHONG SONG, BAUER, Shawn M
Published in Bioorganic & medicinal chemistry letters (03.05.2004)

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Inhibition of Purified Factor Xa Amidolytic Activity May Not Be Predictive of Inhibition of In Vivo Thrombosis: Implications for Identification of Therapeutically Active Inhibitors

Inhibition of Purified Factor Xa Amidolytic Activity May Not Be Predictive of Inhibition of In Vivo Thrombosis: Implications for Identification of Therapeutically Active Inhibitors

by Sinha, Uma, Lin, Pei Hua, Edwards, Susan T, Wong, Paul W, Zhu, Bingyan, Scarborough, Robert M, Su, Ting, Jia, Zhaozhong J, Song, Yonghong, Zhang, Penglie, Clizbe, Lane, Park, Gary, Reed, Andrea, Hollenbach, Stanley J, Malinowski, John, Arfsten, Ann E
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2003)

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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors

by Jia, Zhaozhong J., Wu, Yanhong, Huang, Wenrong, Zhang, Penglie, Song, Yonghong, Woolfrey, John, Sinha, Uma, Arfsten, Ann E., Edwards, Susan T., Hutchaleelaha, Athiwat, Hollennbach, Stanley J., Lambing, Joseph L., Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.03.2004)

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Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn: Potent Antagonists of Platelet Glycoprotein IIb−IIIa

Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn: Potent Antagonists of Platelet Glycoprotein IIb−IIIa

by Fisher, Matthew J, Gunn, Bruce, Harms, Cathy S, Kline, Allen D, Mullaney, Jeffrey T, Nunes, Anne, Scarborough, Robert M, Arfsten, Ann E, Skelton, Marshall A, Um, Suzane L, Utterback, Barbara G, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (20.06.1997)

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Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors

by Su, Ting, Naughton, Mary Ann H, Smyth, Mark S, Rose, Jack W, Arfsten, Ann E, McCowan, Jefferson R, Jakubowski, Joseph A, Wyss, Virginia L, Ruterbories, Kenneth J, Sall, Daniel J, Scarborough, Robert M
Published in Journal of medicinal chemistry (19.12.1997)

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J, Bauer, Shawn M, Goldman, Erick A, Probst, Gary D, Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W, Edwards, Susan T, Arfsten, Ann E, Clizbe, Lane A, Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.04.2009)

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Journal Article

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs

1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs

by Jia, Zhaozhong J., Wu, Yanhong, Huang, Wenrong, Zhang, Penglie, Clizbe, Lane A., Goldman, Erick A., Sinha, Uma, Arfsten, Ann E., Edwards, Susan T., Alphonso, Merlyn, Hutchaleelaha, Athiwat, Scarborough, Robert M., Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (01.03.2004)

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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists

Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists

by Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A
Published in Journal of medicinal chemistry (29.08.1997)

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Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles

Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles

by Sall, Daniel J., Arfsten, Ann E., Berry, Dennis R., Denney, Michael L., Harms, Cathy S., McCowan, Jefferson R., Ray, Judith K., Scarborough, Robert M., Um, Suzane L., Utterback, Barbara G., Jakubowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (09.01.1996)

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In vitro Expression of Escherichia coli Ribosomal Protein Genes: Autogenous Inhibition of Translation

In vitro Expression of Escherichia coli Ribosomal Protein Genes: Autogenous Inhibition of Translation

by Yates, John L., Arfsten, Ann E., Nomura, Masayasu
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.1980)

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Journal Article

Characterization of Human Prorenin Expressed in Mammalian Cells from Cloned cDNA

Characterization of Human Prorenin Expressed in Mammalian Cells from Cloned cDNA

by Fritz, Lawrence C., Arfsten, Ann E., Dzau, Victor J., Atlas, Steven A., Baxter, John D., Fiddes, John C., Shine, John, Cofer, Claire L., Kushner, Peter, Ponte, Phyllis A.
Published in Proceedings of the National Academy of Sciences - PNAS (01.06.1986)

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Isolation and characterization of a promoter mutant in the str ribosomal protein operon in E. coli

Isolation and characterization of a promoter mutant in the str ribosomal protein operon in E. coli

by Post, Leonard E., Arfsten, Ann E., Nomura, Masayasu, Jaskunas, S.Richard
Published in Cell (01.09.1978)

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Journal Article

DNA sequences of promoter regions for the str and spc ribosomal protein operons in E. coli

DNA sequences of promoter regions for the str and spc ribosomal protein operons in E. coli

by Post, Leonard E., Arfsten, Ann E., Reusser, Fritz, Nomura, Masayasu
Published in Cell (01.09.1978)

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Journal Article

MEMBRANE-DERIVED ANTIFLEA VACCINES

MEMBRANE-DERIVED ANTIFLEA VACCINES

by ROBYN E BOREHAM, MILES K YAMANAKE, BEVERLY DALE, LYNNOR B STEVENSON, ANN E ARFSTEN, JOAN P OPDEBEECK, ANDREW W HEATH
Year of Publication 17.03.1992

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Patent

MEMBRANE-DERIVED ANTIFLEA VACCINES

MEMBRANE-DERIVED ANTIFLEA VACCINES

by ARFSTEN, ANN, E, DALE, BEVERLY, HEATH, ANDREW, W, OPDEBEECK, JOAN, P, STEVENSON, LYNNOR, B, BOREHAM, ROBYN, E, YAMANAKE, MILES, K
Year of Publication 05.03.1992

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Patent