Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
Welsh, Kate, Milutinovic, Snezana, Ardecky, Robert J, Gonzalez-Lopez, Marcos, Ganji, Santhi Reddy, Teriete, Peter, Finlay, Darren, Riedl, Stefan, Matsuzawa, Shu-Ichi, Pinilla, Clemencia, Houghten, Richard, Vuori, Kristiina, Reed, John C, Cosford, Nicholas D P
Published in PloS one (12.09.2016)
Published in PloS one (12.09.2016)
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase
Stanford, Stephanie M, Aleshin, Alexander E, Zhang, Vida, Ardecky, Robert J, Hedrick, Michael P, Zou, Jiwen, Ganji, Santhi R, Bliss, Matthew R, Yamamoto, Fusayo, Bobkov, Andrey A, Kiselar, Janna, Liu, Yingge, Cadwell, Gregory W, Khare, Shilpi, Yu, Jinghua, Barquilla, Antonio, Chung, Thomas D Y, Mustelin, Tomas, Schenk, Simon, Bankston, Laurie A, Liddington, Robert C, Pinkerton, Anthony B, Bottini, Nunzio
Published in Nature chemical biology (27.03.2017)
Published in Nature chemical biology (27.03.2017)
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Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells
YUHONG CHEN, DOKMANOVIC, Milos, STEIN, Wilfred D, ARDECKY, Robert J, RONINSON, Igor B
Published in Cancer research (Chicago, Ill.) (01.09.2006)
Published in Cancer research (Chicago, Ill.) (01.09.2006)
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Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes
Leibowitz, Mark D, Ardecky, Robert J, Boehm, Marcus F, Broderick, Carol L, Carfagna, Mark A, Crombie, Diane L, D’Arrigo, Jennifer, Etgen, Garrett J, Faul, Margaret M, Grese, Timothy A, Havel, Henry, Hein, Nancy I, Heyman, Richard A, Jolley, Diane, Klausing, Kay, Liu, Sha, Mais, Dale E, Mapes, Christopher M, Marschke, Keith B, Michellys, Pierre-Yves, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Pascual, Bernadette, Rungta, Deepa, Tyhonas, John S, Urcan, Mary S, Wardlow, Marilyn, Yumibe, Nathan, Reifel-Miller, Anne
Published in Endocrinology (Philadelphia) (01.02.2006)
Published in Endocrinology (Philadelphia) (01.02.2006)
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1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy
STANFORD, STEPHANIE M., DIAZ, MICHAEL A., ZOU, JIWEN J., ARDECKY, ROBERT J., PINKERTON, ANTHONY, BOTTINI, NUNZIO
Published in Diabetes (New York, N.Y.) (01.06.2020)
Published in Diabetes (New York, N.Y.) (01.06.2020)
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TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling
Masyuk, Tatyana V., Masyuk, Anatoliy I., Lorenzo Pisarello, Maria, Howard, Brynn N., Huang, Bing Q., Lee, Pui‐Yuen, Fung, Xavier, Sergienko, Eduard, Ardecky, Robert J., Chung, Thomas D.Y., Pinkerton, Anthony B., LaRusso, Nicholas F.
Published in Hepatology (Baltimore, Md.) (01.10.2017)
Published in Hepatology (Baltimore, Md.) (01.10.2017)
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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase
Stanford, Stephanie M, Diaz, Michael A, Ardecky, Robert J, Zou, Jiwen, Roosild, Tarmo, Holmes, Zachary J, Nguyen, Tiffany P, Hedrick, Michael P, Rodiles, Socorro, Guan, April, Grotegut, Stefan, Santelli, Eugenio, Chung, Thomas D. Y, Jackson, Michael R, Bottini, Nunzio, Pinkerton, Anthony B
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth
Iizuka, Shinji, Quintavalle, Manuela, Navarro, Jose C, Gribbin, Kyle P, Ardecky, Robert J, Abelman, Matthew M, Ma, Chen-Ting, Sergienko, Eduard, Zeng, Fu-Yue, Pass, Ian, Thomas, George V, McWeeney, Shannon K, Hassig, Christian A, Pinkerton, Anthony B, Courtneidge, Sara A
Published in Cancer research (Chicago, Ill.) (15.03.2021)
Published in Cancer research (Chicago, Ill.) (15.03.2021)
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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase
Stanford, Stephanie M, Aleshin, Alexander E, Zhang, Vida, Ardecky, Robert J, Hedrick, Michael P, Zou, Jiwen, Ganji, Santhi R, Bliss, Matthew R, Yamamoto, Fusayo, Bobkov, Andrey A, Kiselar, Janna, Liu, Yingge, Cadwell, Gregory W, Khare, Shilpi, Yu, Jinghua, Barquilla, Antonio, Chung, Thomas D Y, Mustelin, Tomas, Schenk, Simon, Bankston, Laurie A, Liddington, Robert C, Pinkerton, Anthony B, Bottini, Nunzio
Published in Nature chemical biology (01.06.2017)
Published in Nature chemical biology (01.06.2017)
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Discovery of β‑Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators
Pinkerton, Anthony B, Peddibhotla, Satyamaheshwar, Yamamoto, Fusayo, Slosky, Lauren M, Bai, Yushi, Maloney, Patrick, Hershberger, Paul, Hedrick, Michael P, Falter, Bekhi, Ardecky, Robert J, Smith, Layton H, Chung, Thomas D. Y, Jackson, Michael R, Caron, Marc G, Barak, Lawrence S
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs
Finlay, Darren, Vamos, Mitchell, González-López, Marcos, Ardecky, Robert J, Ganji, Santhi Reddy, Yuan, Hongbin, Su, Ying, Cooley, Trina R, Hauser, Curt T, Welsh, Kate, Reed, John C, Cosford, Nicholas D P, Vuori, Kristiina
Published in Molecular cancer therapeutics (01.01.2014)
Published in Molecular cancer therapeutics (01.01.2014)
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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids
Michellys, Pierre-Yves, Ardecky, Robert J, Chen, Jyun-Hung, D'Arrigo, Jennifer, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Montrose-Rafizadeh, Chahrzad, Ogilvie, Katheen M, Reifel-Miller, Anne, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Boehm, Marcus F
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP
Vamos, Mitchell, Welsh, Kate, Finlay, Darren, Lee, Pooi San, Mace, Peter D, Snipas, Scott J, Gonzalez, Monica L, Ganji, Santhi Reddy, Ardecky, Robert J, Riedl, Stefan J, Salvesen, Guy S, Vuori, Kristiina, Reed, John C, Cosford, Nicholas D. P
Published in ACS chemical biology (19.04.2013)
Published in ACS chemical biology (19.04.2013)
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Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP
Ardecky, Robert J., Welsh, Kate, Finlay, Darren, Lee, Pooi San, González-López, Marcos, Ganji, Santhi Reddy, Ravanan, Palaniyandi, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
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LGD-5552, an Antiinflammatory Glucocorticoid Receptor Ligand with Reduced Side Effects, in Vivo
López, Francisco J, Ardecky, Robert J, Bebo, Bruce, Benbatoul, Khalid, De Grandpre, Louise, Liu, Sha, Leibowitz, Mark D, Marschke, Keith, Rosen, Jon, Rungta, Deepa, Viveros, Humberto O, Yen, Wan-Ching, Zhi, Lin, Negro-Vilar, Andrés, Miner, Jeffrey N
Published in Endocrinology (Philadelphia) (01.05.2008)
Published in Endocrinology (Philadelphia) (01.05.2008)
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Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
González-Lόpez, Marcos, Welsh, Kate, Finlay, Darren, Ardecky, Robert J., Ganji, Santhi Reddy, Su, Ying, yuan, Hongbin, Teriete, Peter, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D.P.
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
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Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes
Ardecky, Robert J., Bobkova, Ekaterina V., Kiffer-Moreira, Tina, Brown, Brock, Ganji, Santhi, Zou, Jiwen, Pass, Ian, Narisawa, Sonoko, Iano, Flávia Godoy, Rosenstein, Craig, Cheltsov, Anton, Rascon, Justin, Hedrick, Michael, Gasior, Carlton, Forster, Anita, Shi, Shenghua, Dahl, Russell, Vasile, Stefan, Su, Ying, Sergienko, Eduard, Chung, Thomas D.Y., Kaunitz, Jonathan, Hoylaerts, Marc F., Pinkerton, Anthony B., Millán, José Luis
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical models
ETGEN, Garret J, OLDHAM, Brian A, SHUKER, Anthony J, RITO, Christopher J, MCCARTHY, James R, ARDECKY, Robert J, TYHONAS, John S, DANA, Sharon L, BILAKOVICS, James M, PATERNITI, James R, OGILVIE, Kathleen M, SHA LIU, JOHNSON, William T, KAUFFMAN, Raymond F, BRODERICK, Carol L, MONTROSE, Chahrzad R, BROZINICK, Joseph T, MISENER, Elizabeth A, BEAN, James S, BENSCH, William R, BROOKS, Dawn A
Published in Diabetes (New York, N.Y.) (01.04.2002)
Published in Diabetes (New York, N.Y.) (01.04.2002)
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Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists
Xu, Yanping, Rito, Christopher J, Etgen, Garret J, Ardecky, Robert J, Bean, James S, Bensch, William R, Bosley, Jacob R, Broderick, Carol L, Brooks, Dawn A, Dominianni, Samuel J, Hahn, Patric J, Liu, Sha, Mais, Dale E, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathy M, Oldham, Brian A, Peters, Mary, Rungta, Deepa K, Shuker, Anthony J, Stephenson, Gregory A, Tripp, Allie E, Wilson, Sarah B, Winneroski, Leonard L, Zink, Richard, Kauffman, Raymond F, McCarthy, James R
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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5 (Z) -Benzylidene -1,2 -dihydro -9 -hydroxy -10 -methoxy -2,2, 4 -trimethyl -5H-1 -aza -6 -oxa -chrysenes as non-steroidal glucocorticoid receptor modulators
ARDECKY, Robert J, HUDSON, Andrew R, LOPEZ, Francisco J, MARSCHKE, Keith B, MINER, Jeffrey N, KARANEWSKY, Donald S, NEGRO-VILAR, Andrés, LIN ZHI, PHILLIPS, Dean P, TYHONAS, John S, DECKHUT, Charlotte, LAU, Thomas L, YONGKAI LI, MARTINBOROUGH, Esther A, ROACH, Steven L, HIGUCHI, Robert I
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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