Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
Hirai, Hiroshi, Iwasawa, Yoshikazu, Okada, Megumu, Arai, Tsuyoshi, Nishibata, Toshihide, Kobayashi, Makiko, Kimura, Toshifumi, Kaneko, Naoki, Ohtani, Junko, Yamanaka, Kazunori, Itadani, Hiraku, Takahashi-Suzuki, Ikuko, Fukasawa, Kazuhiro, Oki, Hiroko, Nambu, Tadahiro, Jiang, Jian, Sakai, Takumi, Arakawa, Hiroharu, Sakamoto, Toshihiro, Sagara, Takeshi, Yoshizumi, Takashi, Mizuarai, Shinji, Kotani, Hidehito
Published in Molecular cancer therapeutics (01.11.2009)
Published in Molecular cancer therapeutics (01.11.2009)
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Cystatin-like Metastasis-associated Protein mRNA Expression in Human Colorectal Cancer Is Associated with Both Liver Metastasis and Patient Survival
UTSUNOMIYA, Tohru, HARA, Yoshikazu, KATAOKA, Akemi, MORITA, Masashi, ARAKAWA, Hiroharu, MORI, Masaki, NISHIMURA, Susumu
Published in Clinical cancer research (01.08.2002)
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Published in Clinical cancer research (01.08.2002)
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Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha- ras-transformed NIH 3T3 cells
Okura, Akira, Arakawa, Hiroharu, Oka, Hirofumi, Yoshinari, Tomoko, Monden, Yoshiaki
Published in Biochemical and biophysical research communications (30.11.1988)
Published in Biochemical and biophysical research communications (30.11.1988)
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In vivo Anti‐tumor Activity of a Novel Indolocarbazole Compound, J‐107088, on Murine and Human Tumors Transplanted into Mice
Arakawa, Hiroharu, Morita, Masashi, Kodera, Tsutomu, Okura, Akira, Ohkubo, Mitsuru, Morishima, Hajime, Nishimura, Susumu
Published in Cancer science (01.10.1999)
Published in Cancer science (01.10.1999)
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Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells
FUTAMURA, Mayumi, KAMIYA, Seigo, TSUKAMOTO, Masao, HIRANO, Atsushi, MONDEN, Yoshiaki, ARAKAWA, Hiroharu, NISHIMURA, Susumu
Published in Oncogene (11.10.2001)
Published in Oncogene (11.10.2001)
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Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings
Ohkubo, Mitsuru, Nishimura, Teruyuki, Honma, Teruki, Nishimura, Ikuko, Ito, Satoru, Yoshinari, Tomoko, Arakawa, Hiroharu, Suda, Hiroyuki, Morishima, Hajime, Nishimura, Susumu
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
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Antimetastatic Effect of a Novel Indolocarbazole (NB‐506) on IMC‐HM Murine Tumor Cells Metastasized to the Liver
Arakawa, Hiroharu, Matsumoto, Hiroyoshi, Morita, Masashi, Sasaki, Minoru, Taguchi, Kazuhiro, Okura, Akira, Nishimura, Susumu
Published in Cancer science (01.05.1996)
Published in Cancer science (01.05.1996)
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A NEW ANTITUMOR SUBSTANCE, BE-13793C, PRODUCED BY A STREPTOMYCETE: TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITY
KOJIRI, KATSUHISA, KONDO, HISAO, YOSHINARI, TOMOKO, ARAKAWA, HIROHARU, NAKAJIMA, SHIGERU, SATOH, FUMIO, KAWAMURA, KENJI, OKURA, AKIRA, SUDA, HIROYUKI, OKANISHI, MASANORI
Published in Journal of antibiotics (01.07.1991)
Published in Journal of antibiotics (01.07.1991)
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A New Antitumor Antibiotic, BE-19412A, Produced by a Streptomycete
TSUKAMOTO, MASAO, NAKAJIMA, SHIGERU, ARAKAWA, HIROHARU, SUGIURA, YASUYUKI, SUZUKI, HAJIME, HIRAYAMA, MIOKO, KAMIYA, SEIGO, TESHIMA, YOSHIHIRO, KONDO, HISAO, KOJIRI, KATSUHISA, SUDA, HIROYUKI
Published in Journal of antibiotics (01.10.1998)
Published in Journal of antibiotics (01.10.1998)
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A NEW TOPOISOMERASE II INHIBITOR, BE-22179, PRODUCED BY A STREPTOMYCETE: I. PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY
OKADA, HIROMASA, SUZUKI, HAJIME, YOSHINARI, TOMOKO, ARAKAWA, HIROHARU, OKURA, AKIRA, SUDA, HIROYUKI, YAMADA, AKIHIRO, UEMURA, DAISUKE
Published in Journal of antibiotics (1994)
Published in Journal of antibiotics (1994)
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Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase i inhibitors with an indolocarbazole structure
KOMATANI, Hideya, KOTANI, Hidehito, HARA, Yoshikazu, NAKAGAWA, Rinako, MATSUMOTO, Mami, ARAKAWA, Hiroharu, NISHIMURA, Susumu
Published in Cancer research (Chicago, Ill.) (01.04.2001)
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Published in Cancer research (Chicago, Ill.) (01.04.2001)
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NEW ANTITUMOR SUBSTANCES, BE-12406A AND BE-12406B, PRODUCED BY A STREPTOMYCETE: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
KOJIRI, KATSUHISA, ARAKAWA, HIROHARU, SATOH, FUMIO, KAWAMURA, KENJI, OKURA, AKIRA, SUDA, HIROYUKI, OKANISHI, MASANORI
Published in Journal of antibiotics (1991)
Published in Journal of antibiotics (1991)
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CMAP : A novel cystatin-like gene involved in liver metastasis
MORITA, M, YOSHIUCHI, N, ARAKAWA, H, NISHIMURA, S
Published in Cancer research (Chicago, Ill.) (1999)
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Published in Cancer research (Chicago, Ill.) (1999)
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Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I
YOSHINARI, T, OHKUBO, M, FUKASAWA, K, EGASHIRA, S.-I, HARA, Y, MATSUMOTO, M, NAKAI, K, ARAKAWA, H, MORISHIMA, H, NISHIMURA, S
Published in Cancer research (Chicago, Ill.) (01.09.1999)
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Published in Cancer research (Chicago, Ill.) (01.09.1999)
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