Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.
Published in Nature communications (17.12.2018)
Published in Nature communications (17.12.2018)
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Journal Article
Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)
Hennessy, Edward J, Adam, Ammar, Aquila, Brian M, Castriotta, Lillian M, Cook, Donald, Hattersley, Maureen, Hird, Alexander W, Huntington, Christopher, Kamhi, Victor M, Laing, Naomi M, Li, Danyang, MacIntyre, Terry, Omer, Charles A, Oza, Vibha, Patterson, Troy, Repik, Galina, Rooney, Michael T, Saeh, Jamal C, Sha, Li, Vasbinder, Melissa M, Wang, Haiyun, Whitston, David
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Discovery of aminopiperidine-based Smac mimetics as IAP antagonists
Hennessy, Edward J., Saeh, Jamal C., Sha, Li, MacIntyre, Terry, Wang, Haiyun, Larsen, Nicholas A., Aquila, Brian M., Ferguson, Andrew D., Laing, Naomi M., Omer, Charles A.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
Hird, Alexander W., Aquila, Brian M., Block, Michael H., Hennessy, Edward J., Kamhi, Victor M., Omer, Charles A., Laing, Naomi M., Saeh, Jamal C., Sha, Li, Yang, Bin
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
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Journal Article
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer
Scott, David A., Aquila, Brian M., Bebernitz, Geraldine A., Cook, Donald J., Dakin, Les A., Deegan, Tracy L., Hattersley, Maureen M., Ioannidis, Stephanos, Lyne, Paul D., Omer, Charles A., Ye, Minwei, Zheng, XiaoLan
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
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Journal Article
치환된 거대고리 화합물 및 관련 치료방법
CHOI YOUNGGI, LEHMANN JONATHAN WARD, HU YUAN, HUYNH HOAN, AQUILA BRIAN M, KARRA SRINIVASA, RAYMER BRIAN KENNETH, VALIULIN ROMAN A, PENNINGTON LEWIS D, MATHARU DALJIT, HALE MICHAEL R, MUGGE INGO, BENTZIEN JOERG MARTIN, WOODS JAMES R
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent
치환된 마크로사이클릭 화합물 및 관련 치료 방법
CHOI YOUNGGI, LEHMANN JONATHAN WARD, BENTZIEN JORG MARTIN, HU YUAN, HUYNH HOAN, AQUILA BRIAN M, KARRA SRINIVASA, RAYMER BRIAN KENNETH, VALIULIN ROMAN A, PENNINGTON LEWIS D, MATHARU DALJIT, HALE MICHAEL R, MUGGE INGO, WOODS JAMES R
Year of Publication 29.07.2022
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Year of Publication 29.07.2022
Patent
Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain
Boger, Dale L, Aquila, Brian M, Tse, Winston C, Searcey, Mark
Published in Tetrahedron letters (02.12.2000)
Published in Tetrahedron letters (02.12.2000)
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Journal Article
Substituted macrocyclic compounds and related methods of treatment
Choi, Younggi, Mugge, Ingo Andreas, Aquila, Brian M, Hale, Michael R, Raymer, Brian Kenneth, Karra, Srinivasa, Hu, Yuan, Matharu, Daljit, Huynh, Hoan, Valiulin, Roman A, Woods, James R, Bentzien, Jörg Martin, Pennington, Lewis D, Lehmann, Jonathan Ward
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
Patent
Substituted macrocyclic compounds and related methods of treatment
Choi, Younggi, Mugge, Ingo Andreas, Aquila, Brian M, Hale, Michael R, Raymer, Brian Kenneth, Karra, Srinivasa, Hu, Yuan, Matharu, Daljit, Huynh, Hoan, Valiulin, Roman A, Woods, James R, Bentzien, Jörg Martin, Pennington, Lewis D, Lehmann, Jonathan Ward
Year of Publication 11.06.2024
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Year of Publication 11.06.2024
Patent
SUBSTITUTED FUSED BICYCLIC MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT
Raymer, Brian Kenneth, Choi, Younggi, Hu, Yuan, Huynh, Hoan, Woods, James R, Mugge, Ingo Andreas, Bentzien, Jörg Martin, Pennington, Lewis D, Aquila, Brian M, Lehmann, Jonathan Ward, Hale, Michael R
Year of Publication 06.06.2024
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Year of Publication 06.06.2024
Patent
SUBSTITUTED CARBAMATE MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT
Raymer, Brian Kenneth, Choi, Younggi, Hu, Yuan, Huynh, Hoan, Woods, James R, Mugge, Ingo Andreas, Bentzien, Jörg Martin, Pennington, Lewis D, Aquila, Brian M, Lehmann, Jonathan Ward, Hale, Michael R
Year of Publication 30.05.2024
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Year of Publication 30.05.2024
Patent
SUBSTITUTED AMIDE MACROCYCLIC COMPOUNDS WITH OREXIN-2 RECEPTOR AGONIST ACTIVITY
Raymer, Brian Kenneth, Choi, Younggi, Hu, Yuan, Huynh, Hoan, Valiulin, Roman A, Woods, James R, Mugge, Ingo Andreas, Bentzien, Jörg Martin, Pennington, Lewis D, Aquila, Brian M, Lehmann, Jonathan Ward, Hale, Michael R
Year of Publication 18.04.2024
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Year of Publication 18.04.2024
Patent
SUBSTITUTED FUSED BICYCLIC MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT
RAYMER, Brian, Kenneth, HUYNH, Hoan, HU, Yuan, BENTZIEN, Jörg Martin, WOODS, James, R, MUGGE, Ingo, Andreas, CHOI, Younggi, AQUILA, Brian, M, HALE, Michael, R, LEHMANN, Jonathan Ward, PENNINGTON, Lewis, D
Year of Publication 10.04.2024
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Year of Publication 10.04.2024
Patent
SUBSTITUTED CARBAMATE MACROCYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT
RAYMER, Brian, Kenneth, HUYNH, Hoan, HU, Yuan, BENTZIEN, Jörg, Martin, LEHMANN, Jonathan, Ward, WOODS, James, R, MUGGE, Ingo, Andreas, CHOI, Younggi, AQUILA, Brian, M, HALE, Michael, R, PENNINGTON, Lewis, D
Year of Publication 10.04.2024
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Year of Publication 10.04.2024
Patent
Substituted Piperidino Compounds and Related Methods of Treatment
Choi, Younggi, Mugge, Ingo Andreas, Aquila, Brian M, Raymer, Brian Kenneth, Karra, Srinivasa, Hu, Yuan, Matharu, Daljit, Huynh, Hoan, Valiulin, Roman A, Woods, James R, Bentzien, Jörg Martin, Pennington, Lewis D, Lehmann, Jonathan Ward
Year of Publication 07.03.2024
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Year of Publication 07.03.2024
Patent
SUBSTITUTED AMIDE MACROCYCLIC COMPOUNDS WITH OREXIN-2 RECEPTOR AGONIST ACTIVITY
RAYMER, Brian, Kenneth, HU, Yuan, HUYNH, Hoan, BENTZIEN, Jörg, Martin, LEHMANN, Jonathan, Ward, WOODS, James, R, MUGGE, Ingo, Andreas, CHOI, Younggi, AQUILA, Brian, M, HALE, Michael, R, VALIULIN, Roman, A, PENNINGTON, Lewis, D
Year of Publication 06.03.2024
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Year of Publication 06.03.2024
Patent