Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Tron, Adriana E, Belmonte, Matthew A, Adam, Ammar, Aquila, Brian M, Boise, Lawrence H, Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J, Gangl, Eric, Gibbons, Francis D, Gregory, Gareth P, Hargreaves, David, Hendricks, J Adam, Johannes, Jeffrey W, Johnstone, Ricky W, Kazmirski, Steven L, Kettle, Jason G, Lamb, Michelle L, Matulis, Shannon M, Nooka, Ajay K, Packer, Martin J, Peng, Bo, Rawlins, Philip B, Robbins, Daniel W, Schuller, Alwin G, Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J Paul, Clark, Edwin A, Wilson, David M, Fawell, Stephen E, Hird, Alexander W
Published in Nature communications (17.12.2018)
Published in Nature communications (17.12.2018)
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Journal Article
Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain
Akçay, Gizem, Belmonte, Matthew A, Aquila, Brian, Chuaqui, Claudio, Hird, Alexander W, Lamb, Michelle L, Rawlins, Philip B, Su, Nancy, Tentarelli, Sharon, Grimster, Neil P, Su, Qibin
Published in Nature chemical biology (01.11.2016)
Published in Nature chemical biology (01.11.2016)
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Journal Article
Effects of Molecular Oxygen, Solvent, and Light on Iridium-Photoredox/Nickel Dual-Catalyzed Cross-Coupling Reactions
Oderinde, Martins S, Varela-Alvarez, Adrian, Aquila, Brian, Robbins, Daniel W, Johannes, Jeffrey W
Published in Journal of organic chemistry (07.08.2015)
Published in Journal of organic chemistry (07.08.2015)
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Journal Article
Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)
Hennessy, Edward J, Adam, Ammar, Aquila, Brian M, Castriotta, Lillian M, Cook, Donald, Hattersley, Maureen, Hird, Alexander W, Huntington, Christopher, Kamhi, Victor M, Laing, Naomi M, Li, Danyang, MacIntyre, Terry, Omer, Charles A, Oza, Vibha, Patterson, Troy, Repik, Galina, Rooney, Michael T, Saeh, Jamal C, Sha, Li, Vasbinder, Melissa M, Wang, Haiyun, Whitston, David
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Discovery of aminopiperidine-based Smac mimetics as IAP antagonists
Hennessy, Edward J., Saeh, Jamal C., Sha, Li, MacIntyre, Terry, Wang, Haiyun, Larsen, Nicholas A., Aquila, Brian M., Ferguson, Andrew D., Laing, Naomi M., Omer, Charles A.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Discovery of (+)-N-(3-Aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a Kinesin Spindle Protein Inhibitor and Potential Anticancer Agent
Theoclitou, Maria-Elena, Aquila, Brian, Block, Michael H, Brassil, Patrick J, Castriotta, Lillian, Code, Erin, Collins, Michael P, Davies, Audrey M, Deegan, Tracy, Ezhuthachan, Jayachandran, Filla, Sandra, Freed, Ellen, Hu, Haiqing, Huszar, Dennis, Jayaraman, Muthusamy, Lawson, Deborah, Lewis, Paula M, Nadella, Murali V. P, Oza, Vibha, Padmanilayam, Maniyan, Pontz, Timothy, Ronco, Lucienne, Russell, Daniel, Whitston, David, Zheng, Xiaolan
Published in Journal of medicinal chemistry (13.10.2011)
Published in Journal of medicinal chemistry (13.10.2011)
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Journal Article
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
Hird, Alexander W., Aquila, Brian M., Block, Michael H., Hennessy, Edward J., Kamhi, Victor M., Omer, Charles A., Laing, Naomi M., Saeh, Jamal C., Sha, Li, Yang, Bin
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
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Journal Article
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer
Scott, David A., Aquila, Brian M., Bebernitz, Geraldine A., Cook, Donald J., Dakin, Les A., Deegan, Tracy L., Hattersley, Maureen M., Ioannidis, Stephanos, Lyne, Paul D., Omer, Charles A., Ye, Minwei, Zheng, XiaoLan
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
Published in Bioorganic & medicinal chemistry letters (01.09.2008)
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Journal Article
Photoredox Mediated Nickel Catalyzed Cross-Coupling of Thiols With Aryl and Heteroaryl Iodides via Thiyl Radicals
Oderinde, Martins S, Frenette, Mathieu, Robbins, Daniel W, Aquila, Brian, Johannes, Jeffrey W
Published in Journal of the American Chemical Society (17.02.2016)
Published in Journal of the American Chemical Society (17.02.2016)
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Journal Article
β‑Functionalization of Saturated Aza-Heterocycles Enabled by Organic Photoredox Catalysis
Holmberg-Douglas, Natalie, Choi, Younggi, Aquila, Brian, Huynh, Hoan, Nicewicz, David A
Published in ACS catalysis (05.03.2021)
Published in ACS catalysis (05.03.2021)
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Journal Article
Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross-Coupling of Primary Aryl Amines with Aryl Halides
Oderinde, Martins S., Jones, Natalie H., Juneau, Antoine, Frenette, Mathieu, Aquila, Brian, Tentarelli, Sharon, Robbins, Daniel W., Johannes, Jeffrey W.
Published in Angewandte Chemie (International ed.) (10.10.2016)
Published in Angewandte Chemie (International ed.) (10.10.2016)
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Journal Article
Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain
Boger, Dale L, Aquila, Brian M, Tse, Winston C, Searcey, Mark
Published in Tetrahedron letters (02.12.2000)
Published in Tetrahedron letters (02.12.2000)
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Journal Article
Discovery and optimization of covalent Bcl-xL antagonists
Mukherjee, Herschel, Su, Nancy, Belmonte, Matthew A., Hargreaves, David, Patel, Joe, Tentarelli, Sharon, Aquila, Brian, Grimster, Neil P.
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
Published in Bioorganic & medicinal chemistry letters (01.12.2019)
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Journal Article
Abstract 3769: Continuous, low intensity systemic dosing maximizes the therapeutic margin of Eg5/KSP inhibition in an orthotopic model of urothelial cell carcinoma
Williams, Leigh, Ellston, Rebecca, Trueman, Dawn, Musgrove, Helen, Ruston, Linette, Aquila, Brian, Pease, Elizabeth, Klein, Stephanie, Davies, Barry R.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract C40: Inhibition of Mcl-1 through covalent modification of a non-catalytic lysine side chain
Su, Qibin, Akçay, Gizem, Grimster, Neil, Belmonte, Matthew, Rawlins, Philip, Lamb, Michelle, Hird, Alexander, Aquila, Brian
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Back Cover: Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross-Coupling of Primary Aryl Amines with Aryl Halides (Angew. Chem. Int. Ed. 42/2016)
Oderinde, Martins S., Jones, Natalie H., Juneau, Antoine, Frenette, Mathieu, Aquila, Brian, Tentarelli, Sharon, Robbins, Daniel W., Johannes, Jeffrey W.
Published in Angewandte Chemie (International ed.) (10.10.2016)
Published in Angewandte Chemie (International ed.) (10.10.2016)
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Journal Article
Discovery and Optimization of a Novel Series of Potent Mutant B-Raf(V600E) Selective Kinase Inhibitors
Vasbinder, Melissa M., Aquila, Brian, Augustin, Martin, Chen, Huawei, Cheung, Tony, Cook, Donald, Drew, Lisa, Fauber, Benjamin P., Glossop, Steve, Grondine, Michael, Hennessy, Edward, Johannes, Jeffrey, Lee, Stephen, Lyne, Paul, Moertl, Mario, Omer, Charles, Palakurthi, Sangeetha, Pontz, Timothy, Read, Jon, Sha, Li, Shen, Minhui, Steinbacher, Stefan, Wang, Haixia, Wu, Allan, Ye, Minwei
Published in Journal of medicinal chemistry (14.03.2013)
Published in Journal of medicinal chemistry (14.03.2013)
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Journal Article
치환된 거대고리 화합물 및 관련 치료방법
CHOI YOUNGGI, LEHMANN JONATHAN WARD, HU YUAN, HUYNH HOAN, AQUILA BRIAN M, KARRA SRINIVASA, RAYMER BRIAN KENNETH, VALIULIN ROMAN A, PENNINGTON LEWIS D, MATHARU DALJIT, HALE MICHAEL R, MUGGE INGO, BENTZIEN JOERG MARTIN, WOODS JAMES R
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
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