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Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice: Correlations With Plaques, Tangles, and Oligomeric Species

by López-González, Irene, Schlüter, Agatha, Aso, Ester, Garcia-Esparcia, Paula, Ansoleaga, Belen, LLorens, Franc, Carmona, Margarita, Moreno, Jesús, Fuso, Andrea, Portero-Otin, Manuel, Pamplona, Reinald, Pujol, Aurora, Ferrer, Isidre
Published in Journal of neuropathology and experimental neurology (01.04.2015)

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Chronic sleep deprivation exacerbates cognitive and synaptic plasticity impairments in APP/PS1 transgenic mice

by Wang, Chun, Gao, Wen-Rui, Yin, Jing, Wang, Zhao-Jun, Qi, Jin-Shun, Cai, Hong-Yan, Wu, Mei-Na
Published in Behavioural brain research (27.08.2021)

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Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice

by Lin, Tzu-Wei, Shih, Yao-Hsiang, Chen, Shean-Jen, Lien, Chi-Hsiang, Chang, Chia-Yuan, Huang, Tung-Yi, Chen, Shun-Hua, Jen, Chauying J., Kuo, Yu-Min
Published in Neurobiology of learning and memory (01.02.2015)

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Aβ ‐induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases

by Zhang, Weidong, Ding, Fan, Rong, Xing, Ren, Qinghua, Hasegawa, Tomoka, Liu, Hongrui, Li, Minqi
Published in Aging cell (01.02.2025)

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PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice

by Wei, Min, Li, Wenjing, Bao, Guangming, Yang, Zhaofei, Li, Song, Le, Weidong
Published in Ecotoxicology and environmental safety (15.09.2025)

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Impact of vitamin A on the risk of mild cognitive impairment and Alzheimer's disease pathology in high‐fat‐diet–treated APP/PS1 mice

by Wang, Xixiang, Guo, Yujie, Li, Pengfei, Ma, Xiaojun, Xu, Jingjing, Liu, Lu, Liu, Yu, Ren, Xiuwen, Wang, Ying, Meng, Liping, Zhou, Shaobo, Yuan, Linhong
Published in Food frontiers (01.03.2025)

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Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status

by Lv, Menglian, Yang, Shengyi, Cai, Lingkai, Qin, Li‐qiang, Li, Bing‐yan, Wan, Zhongxiao
Published in Molecular nutrition & food research (01.12.2018)

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Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice

by Liu, Xia, Wang, Wei, Chen, Hua-li, Zhang, Hai-yan, Zhang, Nai-xia
Published in Acta pharmacologica Sinica (01.10.2019)

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Vitis vinifera L. Flavones Regulate Hippocampal Neurons via Autophagy in APP/PS1 Alzheimer Model Mice

by Zhang, Peng, Maimaiti, Znafuguli, Aili, Gulixiati, Yuan, Fang, Xiao, Hui
Published in Evidence-based complementary and alternative medicine (01.09.2022)

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Alcohol consumption during early adulthood increases the vulnerability of locus coeruleus neurons and amyloid beta pathology in female APP/PS1 mice

by Engel, Shaydel, Dillerud, Madison, Scalf, Matthew, Dobbelmann, Ruth, Du, Yijuan, Lee, Anna M., Graves, Steven M.
Published in Alcohol (Fayetteville, N.Y.) (01.09.2025)

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Herbal Formula Fo Shou San Attenuates Alzheimer’s Disease-Related Pathologies via the Gut-Liver-Brain Axis in APP/PS1 Mouse Model of Alzheimer’s Disease

by Chen, Yuan, Guo, XueJun, Zhang, Yongbin, Liu, Xiaoqiu, Guo, Pengfei, Lu, Jia, Gao, Xin
Published in Evidence-based complementary and alternative medicine (2019)

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Calcium signaling in individual APP/PS1 mouse dentate gyrus astrocytes increases ex vivo with Aβ pathology and age without affecting astrocyte network activity

by Huffels, Christiaan F. M., Osborn, Lana M., Cappaert, Natalie L. M., Hol, Elly M.
Published in Journal of neuroscience research (01.06.2022)

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Neuroprotective Effect of HIIT against GFAP Hypertrophy through Mitochondrial Dynamics in APP/PS1 Mice

by Liu, Qianqian, Fu, Xiaonan, Han, Rui, Liu, Xuefeng, Zhao, Xiantao, Wei, Jianshe
Published in Oxidative medicine and cellular longevity (2022)

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An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease

by Lachén-Montes, Mercedes, González-Morales, Andrea, de Morentin, Xabier Martínez, Pérez-Valderrama, Estela, Ausín, Karina, Zelaya, María Victoria, Serna, Antonio, Aso, Ester, Ferrer, Isidro, Fernández-Irigoyen, Joaquín, Santamaría, Enrique
Published in Journal of proteomics (04.10.2016)

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PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ1−42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice

by Xia, De-Yu, Huang, Xin, Bi, Chong-Feng, Mao, Lin-Ling, Peng, Li-Jun, Qian, Hai-Rong
Published in Frontiers in aging neuroscience (21.03.2017)

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Cell Therapy: A Safe and Efficacious Therapeutic Treatment for Alzheimer’s Disease in APP+PS1 Mice

by Nabar, Neel R., Yuan, Fang, Lin, Xiaoyang, Wang, Li, Bai, Ge, Mayl, Jonathan, Li, Yaqiong, Zhou, Shu-Feng, Wang, Jinhuan, Cai, Jianfeng, Cao, Chuanhai
Published in PloS one (03.12.2012)

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Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

by López-González, Irene, Schlüter, Agatha, Aso, Ester, Garcia-Esparcia, Paula, Ansoleaga, Belen, LLorens, Franc, Carmona, Margarita, Moreno, Jesús, Fuso, Andrea, Portero-Otin, Manuel, Pamplona, Reinald, Pujol, Aurora, Ferrer, Isidre
Published in Journal of neuropathology and experimental neurology (01.04.2015)

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Estrogen Modulates ubc9 Expression and Synaptic Redistribution in the Brain of APP/PS1 Mice and Cortical Neurons

by Lai, Yu-Jie, Liu, Lu, Hu, Xiao-Tong, He, Ling, Chen, Guo-Jun
Published in Journal of molecular neuroscience (01.03.2017)

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PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ 1-42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice

by Xia, De-Yu, Huang, Xin, Bi, Chong-Feng, Mao, Lin-Ling, Peng, Li-Jun, Qian, Hai-Rong
Published in Frontiers in aging neuroscience (2017)

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Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 model of Alzheimer's disease is accompanied by correction in metabolism of sphingolipids, polyamines, and phospholipid saturation composition

by Kalecký, Karel, Buitrago, Luna, Alarcon, Juan Marcos, Singh, Abanish, Bottiglieri, Teodoro, Kaddurah-Daouk, Rima, Hernández, Alejandro Iván
Published in bioRxiv (18.01.2025)

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