Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions
Grant, Joshuaine, Hua, Fei, Apgar, Joshua F., Burke, John M., Marcantonio, Diana H.
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
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Journal Article
Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease
Madrasi, Kumpal, Das, Raibatak, Mohmmadabdul, Hafiz, Lin, Lin, Hyman, Bradley T., Lauffenburger, Douglas A., Albers, Mark W., Rissman, Robert A., Burke, John M., Apgar, Joshua F., Wille, Lucia, Gruenbaum, Lore, Hua, Fei
Published in Alzheimer's & dementia (01.09.2021)
Published in Alzheimer's & dementia (01.09.2021)
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Journal Article
A next generation mathematical model for the in vitro to clinical translation of T-cell engagers
Flowers, David, Bassen, David, Kapitanov, Georgi I., Marcantonio, Diana, Burke, John M., Apgar, Joshua F., Betts, Alison, Hua, Fei
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2023)
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2023)
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Journal Article
Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions
Marcantonio, Diana H, Matteson, Andrew, Presler, Marc, Burke, John M, Hagen, David R, Hua, Fei, Apgar, Joshua F
Published in Frontiers in pharmacology (08.06.2022)
Published in Frontiers in pharmacology (08.06.2022)
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Journal Article
Comparison of dose selection based on target engagement versus inhibition of receptor–ligand interaction for checkpoint inhibitors
Head, Sarah A., Johnson, Carter, Sarkar, Saheli, Matteson, Andrew, Marcantonio, Diana H., Hua, Fei, Burke, John M., Apgar, Joshua F., Flowers, David
Published in CPT: pharmacometrics and systems pharmacology (01.06.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2024)
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Journal Article
Quantitative systems pharmacology model for Alzheimer’s disease to predict the effect of aducanumab on brain amyloid
Lin, Lin, Hua, Fei, Salinas, Cristian, Young, Carissa, Bussiere, Thierry, Apgar, Joshua F., Burke, John M., Kandadi Muralidharan, Kumar, Rajagovindan, Rajasimhan, Nestorov, Ivan
Published in CPT: pharmacometrics and systems pharmacology (01.03.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2022)
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Journal Article
Quantitative systems pharmacology model of GITR‐mediated T cell dynamics in tumor microenvironment
Ji, Yan, Madrasi, Kumpal, Knee, Deborah A., Gruenbaum, Lore, Apgar, Joshua F., Burke, John M., Gomes, Bruce
Published in CPT: pharmacometrics and systems pharmacology (01.03.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2023)
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Journal Article
A systems pharmacology model for gene therapy in sickle cell disease
Zheng, Bo, Wille, Lucia, Peppel, Karsten, Hagen, David, Matteson, Andrew, Ahlers, Jeffrey, Schaff, James, Hua, Fei, Yuraszeck, Theresa, Cobbina, Enoch, Apgar, Joshua F., Burke, John M., Roberts, John, Das, Raibatak
Published in CPT: pharmacometrics and systems pharmacology (01.07.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.07.2021)
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Journal Article
Stimulus design for model selection and validation in cell signaling
Apgar, Joshua F, Toettcher, Jared E, Endy, Drew, White, Forest M, Tidor, Bruce
Published in PLoS computational biology (01.02.2008)
Published in PLoS computational biology (01.02.2008)
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Journal Article
Model-Informed Drug Development of the Masked Anti-PD-L1 Antibody CX-072
Stroh, Mark, Green, Michelle, Millard, Bjorn L, Apgar, Joshua F, Burke, John M, Garner, Will, Lu, Hong, Lyman, Susan K, Desnoyers, Luc R, Richardson, Jennifer, Hannah, Alison, Kavanaugh, W Michael
Published in Clinical pharmacology and therapeutics (01.02.2021)
Published in Clinical pharmacology and therapeutics (01.02.2021)
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Journal Article
Sloppy models, parameter uncertainty, and the role of experimental design
Apgar, Joshua F, Witmer, David K, White, Forest M, Tidor, Bruce
Published in Molecular bioSystems (01.10.2010)
Published in Molecular bioSystems (01.10.2010)
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Journal Article
Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1
Apgar, Joshua F., Tang, Jian‐Ping, Singh, Pratap, Balasubramanian, Nanda, Burke, John, Hodges, Michael R., Lasaro, Melissa A., Lin, Lin, Miliard, Bjorn L., Moore, Kristi, Jun, Lucy S., Sobolov, Susan, Wilkins, Anna Katharina, Gao, Xiang
Published in CPT: pharmacometrics and systems pharmacology (01.06.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2018)
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Journal Article
A quantitative systems pharmacology model of colonic motility with applications in drug development
Das, Raibatak, Wille, Lucia, Zhang, Liming, Chen, Chunlin, Winchester, Wendy, Selimkhanov, Jangir, Wykosky, Jill, Apgar, Joshua F., Burke, John M., Rogge, Mark, Hua, Fei, Vakilynejad, Majid
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2019)
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2019)
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Journal Article
Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer
Sayama, Hiroyuki, Marcantonio, Diana, Nagashima, Takeyuki, Shimazaki, Masashi, Minematsu, Tsuyoshi, Apgar, Joshua F, Burke, John M., Wille, Lucia, Nagasaka, Yasuhisa, Kirouac, Daniel C.
Published in CPT: pharmacometrics and systems pharmacology (01.08.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.08.2021)
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Journal Article
Quantitative systems toxicology
Bloomingdale, Peter, Housand, Conrad, Apgar, Joshua F., Millard, Bjorn L., Mager, Donald E., Burke, John M., Shah, Dhaval K.
Published in Current opinion in toxicology (01.06.2017)
Published in Current opinion in toxicology (01.06.2017)
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Journal Article
Reply to Comment on "Sloppy models, parameter uncertainty, and the role of experimental design"
Hagen, David R, Apgar, Joshua F, Witmer, David K, White, Forest M, Tidor, Bruce
Published in Molecular bioSystems (01.08.2011)
Published in Molecular bioSystems (01.08.2011)
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