AB‐Bind: Antibody binding mutational database for computational affinity predictions
Sirin, Sarah, Apgar, James R., Bennett, Eric M., Keating, Amy E.
Published in Protein science (01.02.2016)
Published in Protein science (01.02.2016)
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Journal Article
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
Apgar, James R, Tam, Amy S P, Sorm, Rhady, Moesta, Sybille, King, Amy C, Yang, Han, Kelleher, Kerry, Murphy, Denise, D'Antona, Aaron M, Yan, Guoying, Zhong, Xiaotian, Rodriguez, Linette, Ma, Weijun, Ferguson, Darren E, Carven, Gregory J, Bennett, Eric M, Lin, Laura
Published in PloS one (07.05.2020)
Published in PloS one (07.05.2020)
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Journal Article
Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody
Campbell, Sharon M, DeBartolo, Joseph, Apgar, James R, Mosyak, Lydia, McManus, Virginie, Beyer, Sonia, Bennett, Eric M, Lambert, Matthew, Cunningham, Orla
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody
Apgar, James R, Mader, Michelle, Agostinelli, Rita, Benard, Susan, Bialek, Peter, Johnson, Mark, Gao, Yijie, Krebs, Mark, Owens, Jane, Parris, Kevin, St Andre, Michael, Svenson, Kris, Morris, Carl, Tchistiakova, Lioudmila
Published in mAbs (02.10.2016)
Published in mAbs (02.10.2016)
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Journal Article
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
Townsend, Sue, Fennell, Brian J., Apgar, James R., Lambert, Matthew, McDonnell, Barry, Grant, Joanne, Wade, Jason, Franklin, Edward, Foy, Niall, Shúilleabháin, Deirdre Ní, Fields, Conor, Darmanin-Sheehan, Alfredo, King, Amy, Paulsen, Janet E., Hickling, Timothy P., Tchistiakova, Lioudmila, Cunningham, Orla, Finlay, William J. J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.2015)
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Journal Article
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease
Zhong, Xiaotian, Jagarlapudi, Srinath, Weng, Yan, Ly, Mellisa, Rouse, Jason C., McClure, Kim, Ishino, Tetsuya, Zhang, Yan, Sousa, Eric, Cohen, Justin, Tzvetkova, Boriana, Cote, Kaffa, Scarcelli, John J., Johnson, Keith, Palandra, Joe, Apgar, James R., Yaddanapudi, Suma, Gonzalez-Villalobos, Romer A., Opsahl, Alan C., Lam, Khetemenee, Yao, Qing, Duan, Weili, Sievers, Annette, Zhou, Jing, Ferguson, Darren, D'Antona, Aaron, Zollner, Richard, Zhu, Hongli L., Kriz, Ron, Lin, Laura, Clerin, Valerie
Published in The Journal of biological chemistry (06.03.2020)
Published in The Journal of biological chemistry (06.03.2020)
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Journal Article
Modeling Backbone Flexibility to Achieve Sequence Diversity: The Design of Novel α-Helical Ligands for Bcl-xL
Fu, Xiaoran, Apgar, James R., Keating, Amy E.
Published in Journal of molecular biology (24.08.2007)
Published in Journal of molecular biology (24.08.2007)
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Journal Article
Predicting helix orientation for coiled-coil dimers
Apgar, James R., Gutwin, Karl N., Keating, Amy E.
Published in Proteins, structure, function, and bioinformatics (15.08.2008)
Published in Proteins, structure, function, and bioinformatics (15.08.2008)
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Journal Article
Cluster expansion models for flexible-backbone protein energetics
Apgar, James R, Hahn, Seungsoo, Grigoryan, Gevorg, Keating, Amy E
Published in Journal of computational chemistry (30.11.2009)
Published in Journal of computational chemistry (30.11.2009)
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Journal Article
TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
BENARD SUSAN, HETT SUNITA R, STAHL MARK, APGAR JAMES R, CARVEN GREGORY J, JIN MACY, JASUJA REEMA, JUO ZONG SEAN, HOLSTI MATTHEW, PITTMAN DEBRA
Year of Publication 31.05.2023
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Year of Publication 31.05.2023
Patent
TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
BENARD SUSAN, HETT SUNITA R, STAHL MARK, APGAR JAMES R, CARVEN GREGORY J, JIN MACY, JASUJA REEMA, JUO ZONG SEAN, HOLSTI MATTHEW, PITTMAN DEBRA
Year of Publication 07.10.2022
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Year of Publication 07.10.2022
Patent
항-GDF15 항체, 조성물 및 사용 방법
HE TAO, BEAUMONT KEVIN CHARLES, SHCHORS KSENYA, APGAR JAMES R, CHABOT JEFFREY RAYMOND, LAMBERT MATTHEW ALLISTER, BREEN DANNA M
Year of Publication 06.05.2021
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Year of Publication 06.05.2021
Patent
TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
BENARD SUSAN, HETT SUNITA R, STAHL MARK, APGAR JAMES R, CARVEN GREGORY J, JIN MACY, JASUJA REEMA, JUO ZONG SEAN, HOLSTI MATTHEW, PITTMAN DEBRA
Year of Publication 20.08.2019
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Year of Publication 20.08.2019
Patent
조직 인자 경로 억제제 항체 및 그의 용도
BENARD SUSAN, HETT SUNITA R, STAHL MARK, APGAR JAMES R, CARVEN GREGORY J, JIN MACY, JASUJA REEMA, JUO ZONG SEAN, HOLSTI MATTHEW, PITTMAN DEBRA
Year of Publication 26.03.2018
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Year of Publication 26.03.2018
Patent
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors
Root, Adam R, Guntas, Gurkan, Katragadda, Madan, Apgar, James R, Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C, Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E, Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R, Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R, D'Antona, Aaron M, Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Journal Article
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer
Root, Adam, Cao, Wei, Li, Bilian, LaPan, Peter, Meade, Caryl, Sanford, Jocelyn, Jin, Macy, O’Sullivan, Cliona, Cummins, Emma, Lambert, Matthew, Sheehan, Alfredo, Ma, Weijun, Gatto, Scott, Kerns, Kelvin, Lam, Khetemenee, D’Antona, Aaron, Zhu, Lily, Brady, William, Benard, Susan, King, Amy, He, Tao, Racie, Lisa, Arai, Maya, Barrett, Dianah, Stochaj, Wayne, LaVallie, Edward, Apgar, James, Svenson, Kristine, Mosyak, Lidia, Yang, Yinhua, Chichili, Gurunadh, Liu, Liqin, Li, Hua, Burke, Steve, Johnson, Syd, Alderson, Ralph, Finlay, William, Lin, Laura, Olland, Stéphane, Somers, William, Bonvini, Ezio, Gerber, Hans-Peter, May, Chad, Moore, Paul, Tchistiakova, Lioudmila, Bloom, Laird
Published in Antibodies (Basel) (04.03.2016)
Published in Antibodies (Basel) (04.03.2016)
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Journal Article
TISSUE FACTOR PATHWAY INHIBITOR ANTIBODIES AND USES THEREOF
Jin, Macy, Apgar, James R, Hett, Sunita R, Pittman, Debra, Stahl, Mark, Holsti, Matthew, Jasuja, Reema, Benard, Susan, Carven, Gregory J, Juo, Zong Sean
Year of Publication 28.12.2023
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Year of Publication 28.12.2023
Patent
Anti-GDF15 antibodies, compositions and methods of use
He, Tao, Lambert, Matthew Allister, Breen, Danna M, Apgar, James R, Beaumont, Kevin Charles, Chabot, Jeffrey Raymond, Shchors, Ksenya
Year of Publication 31.01.2023
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Year of Publication 31.01.2023
Patent