Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors
Sommer, Anette, Kopitz, Charlotte, Schatz, Christoph A, Nising, Carl F, Mahlert, Christoph, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Hammer, Stefanie, Greven, Simone, Schuhmacher, Joachim, Braun, Manuela, Zierz, Ruprecht, Wittemer-Rump, Sabine, Harrenga, Axel, Dittmer, Frank, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Huynh, Hung, Ziegelbauer, Karl, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (01.11.2016)
Published in Cancer research (Chicago, Ill.) (01.11.2016)
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Journal Article
Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer
Willuda, Jörg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Stelte-Ludwig, Beatrix, Pena, Carol, Lange, Claudia, Golfier, Sven, Kneip, Christoph, Carrigan, Patricia E, Mclean, Kirk, Schuhmacher, Joachim, von Ahsen, Oliver, Müller, Jörg, Dittmer, Frank, Beier, Rudolf, El Sheikh, Sherif, Tebbe, Jan, Leder, Gabriele, Apeler, Heiner, Jautelat, Rolf, Ziegelbauer, Karl, Kreft, Bertolt
Published in Molecular cancer therapeutics (01.05.2017)
Published in Molecular cancer therapeutics (01.05.2017)
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Journal Article
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system : stimulation by YC-1, nitric oxide, and carbon monoxide
HOENICKA, M, BECKER, E.-M, APELER, H, SIRICHOKE, T, SCHRÖDER, H, GERZER, R, STASCH, J.-P
Published in Journal of molecular medicine (Berlin, Germany) (1999)
Published in Journal of molecular medicine (Berlin, Germany) (1999)
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Conference Proceeding
Journal Article
Abstract 1210: Preclinical pharmacology and repeated dose toxicity of the novel agonistic TWEAK receptor binding antibody BAY-356
Berndt, Sandra, Votsmeier, Christian, Zierz, Ruprecht, Walter, Jakob, Frisk, Anna-Lena, Hammer, Stefanie, Apeler, Heiner, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 3234: Development of potent and selective antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class
Lerchen, Hans-Georg, Wittrock, Sven, Griebenow, Nils, Lobell, Mario, Rebstock, Anne-Sophie, Cancho-Grande, Yolanda, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Sommer, Anette, Berndt, Sandra, Terjung, Carsten, Apeler, Heiner, Kreft, Bertolt, Jautelat, Rolf
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 46: Preclinical activity of novel antibody-drug conjugates with pyrrole-based kinesin spindle protein inhibitors targeting different tumor antigens
Sommer, Anette, Berndt, Sandra, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Wittrock, Sven, Rebstock, Anne-Sophie, Dietz, Lisa, Mahlert, Christoph, Greven, Simone, Griebenow, Nils, Cancho-Grande, Yolanda, Jautelat, Rolf, Apeler, Heiner, Kreft, Bertolt
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 1771: BAY 1834942 is an immunotherapeutic antibody blocking the novel immune checkpoint regulator CEACAM6 (CD66c)
Willuda, Joerg, Trautwein, Mark, Pinkert, Jessica, Doecke, Wolf-Dietrich, Boehm, Hans-Henning, Wessel, Florian, Ge, Yingzi, Gutierrez, Eva Maria, Weiske, Joerg, Freiberg, Christoph, Gritzan, Uwe, Glueck, Julian, Zopf, Dieter, Golfier, Sven, Ahsen, Oliver von, Zierz, Ruprecht, Wittemer-Rump, Sabine, Apeler, Heiner, Karl, Ziegelbauer, Offringa, Rienk, Kreft, Bertolt, Philipp, Beckhove
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4953: Stromal endosialin modulates the proinflammatory tumor microenvironment and is crucial for the growth of orthotopic pancreatic tumors
Christian, Sven, Sivanandam, Vijaysahankar, Strerath, Michael, Apeler, Heiner, Hess-Stumpp, Holger, Augustin, Hellmut G.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
NO-independent regulatory site on soluble guanylate cyclase
Stasch, Johannes-Peter, Becker, Eva Maria, Alonso-Alija, Cristina, Apeler, Heiner, Dembowsky, Klaus, Feurer, Achim, Gerzer, Rupert, Minuth, Torsten, Perzborn, Elisabeth, Pleiß, Ulrich, Schröder, Henning, Schroeder, Werner, Stahl, Elke, Steinke, Wolfram, Straub, Alexander, Schramm, Matthias
Published in Nature (London) (08.03.2001)
Published in Nature (London) (08.03.2001)
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Journal Article
NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
Stasch, Johannes‐Peter, Schmidt, Peter, Alonso‐Alija, Cristina, Apeler, Heiner, Dembowsky, Klaus, Haerter, Michael, Heil, Markus, Minuth, Torsten, Perzborn, Elisabeth, Pleiss, Ulrich, Schramm, Matthias, Schroeder, Werner, Schröder, Henning, Stahl, Elke, Steinke, Wolfram, Wunder, Frank
Published in British journal of pharmacology (01.07.2002)
Published in British journal of pharmacology (01.07.2002)
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Journal Article
Abstract 4491: FGFR2-ADC potently and selectively inhibits growth of gastric and breast cancer xenograft models
Sommer, Anette, Nising, Carl F., Mahlert, Christoph, Kopitz, Charlotte C., Lerchen, Hans-Georg, Greven, Simone, Stelte-Ludwig, Beatrix, Schuhmacher, Joachim, Zierz, Ruprecht, Wittemer-Rump, Sabine, Schatz, Christoph, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Kreft, Bertolt, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 5445: Preclinical anti-tumor efficacy of an anti-C4.4a (LYPD3) antibody drug conjugate for the treatment of lung squamous cell carcinoma
Willuda, Joerg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Golfier, Sven, Bach, Ute, Schumacher, Joachim, Stelte-Ludwig, Beatrix, Ahsen, Oliver Von, Schneider, Claudia, Dittmer, Frank, Beier, Rudolf, El-Sheik, Sherif, Tebbe, Jan, Leder, Gabriele, Apeler, Heiner, Jautelat, Rolf, Kreft, Bertolt, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Pharmacological actions of a novel NO‐independent guanylyl cyclase stimulator, BAY 41‐8543: in vitro studies
Stasch, Johannes‐Peter, Alonso‐Alija, Cristina, Apeler, Heiner, Dembowsky, Klaus, Feurer, Achim, Minuth, Torsten, Perzborn, Elisabeth, Schramm, Matthias, Straub, Alexander
Published in British journal of pharmacology (01.01.2002)
Published in British journal of pharmacology (01.01.2002)
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Journal Article
MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF
WANG JUN, JIANG XIAOQIAO, PATEL CHANDRA, APELER HEINER, BROOKS ALAN, GRITZAN UWE
Year of Publication 11.06.2012
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Year of Publication 11.06.2012
Patent
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
Becker, E M, Alonso-Alija, C, Apeler, H, Gerzer, R, Minuth, T, Pleiss, U, Schmidt, P, Schramm, M, Schröder, H, Schroeder, W, Steinke, W, Straub, A, Stasch, J P
Published in BMC pharmacology (28.12.2001)
Published in BMC pharmacology (28.12.2001)
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