How long is long enough to secure disease control after low-dose-rate brachytherapy in combination with other modalities in intermediate-risk, localized prostate cancer?
Urabe, Fumihiko, Kimura, Takahiro, Sasaki, Hiroshi, Tashiro, Kojiro, Iwatani, Kosuke, Yasue, Keiji, Aoki, Manabu, Sato, Shun, Takahashi, Hiroyuki, Miki, Kenta, Egawa, Shin
Published in International journal of clinical oncology (2022)
Published in International journal of clinical oncology (2022)
Get full text
Journal Article
Structure-Based Design of Highly Potent HIV‑1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X‑ray Structural Studies
Ghosh, Arun K, Kovela, Satish, Osswald, Heather L, Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
Get full text
Journal Article
Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
Bulut, Haydar, Hattori, Shin-Ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Scientific reports (30.06.2020)
Published in Scientific reports (30.06.2020)
Get full text
Journal Article
Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance
Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K, Mitsuya, Hiroaki
Published in mBio (06.03.2018)
Published in mBio (06.03.2018)
Get full text
Journal Article
Prognostic value of PSA bounce after definitive radiotherapy revisited
Urabe, Fumihiko, Kimura, Takahiro, Sasaki, Hiroshi, Tashiro, Kojiro, Iwatani, Kosuke, Aoki, Manabu, Sato, Shun, Takahashi, Hiroyuki, Miki, Kenta, Egawa, Shin
Published in International journal of clinical oncology (01.02.2022)
Published in International journal of clinical oncology (01.02.2022)
Get full text
Journal Article
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Published in eLife (17.10.2017)
Published in eLife (17.10.2017)
Get full text
Journal Article
Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir
Hayashi, Hironori, Takamune, Nobutoki, Nirasawa, Takashi, Aoki, Manabu, Morishita, Yoshihiko, Das, Debananda, Koh, Yasuhiro, Ghosh, Arun K., Misumi, Shogo, Mitsuya, Hiroaki
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2014)
Get full text
Journal Article
Prognostic value of PSA bounce in prostate cancer following definitive radiation therapy: a systematic review and meta-analysis
Urabe, Fumihiko, Kimura, Shoji, Tashiro, Kojiro, Kido, Masahito, Sasaki, Hiroshi, Aoki, Manabu, Kimura, Takahiro, Miki, Kenta, Egawa, Shin
Published in Prostate cancer and prostatic diseases (01.12.2021)
Published in Prostate cancer and prostatic diseases (01.12.2021)
Get full text
Journal Article
Comparison of outcomes in high-risk prostate cancer patients treated with low-/high-dose-rate brachytherapy plus external beam radiotherapy
Imai, Yu, Urabe, Fumihiko, Iwatani, Kosuke, Nakazono, Minoru, Tashiro, Kojiro, Honda, Mariko, Aoki, Manabu, Sato, Shun, Takahashi, Hiroyuki, Miki, Kenta, Kimura, Takahiro
Published in International journal of clinical oncology (01.05.2023)
Published in International journal of clinical oncology (01.05.2023)
Get full text
Journal Article
Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation
Ghosh, Arun K., Williams, Jacqueline N., Kovela, Satish, Takayama, Jun, Simpson, Hannah M., Walters, D. Eric, Hattori, Shin-ichiro, Aoki, Manabu, Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Get full text
Journal Article
Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2
Higashi-Kuwata, Nobuyo, Tsuji, Kohei, Hayashi, Hironori, Bulut, Haydar, Kiso, Maki, Imai, Masaki, Ogata-Aoki, Hiromi, Ishii, Takahiro, Kobayakawa, Takuya, Nakano, Kenta, Takamune, Nobutoki, Kishimoto, Naoki, Hattori, Shin-ichiro, Das, Debananda, Uemura, Yukari, Shimizu, Yosuke, Aoki, Manabu, Hasegawa, Kazuya, Suzuki, Satoshi, Nishiyama, Akie, Saruwatari, Junji, Shimizu, Yukiko, Sukenaga, Yoshikazu, Takamatsu, Yuki, Tsuchiya, Kiyoto, Maeda, Kenji, Yoshimura, Kazuhisa, Iida, Shun, Ozono, Seiya, Suzuki, Tadaki, Okamura, Tadashi, Misumi, Shogo, Kawaoka, Yoshihiro, Tamamura, Hirokazu, Mitsuya, Hiroaki
Published in Nature communications (25.02.2023)
Published in Nature communications (25.02.2023)
Get full text
Journal Article
Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies
Ghosh, Arun K., Xia, Zilei, Kovela, Satish, Robinson, William L., Johnson, Megan E., Kneller, Daniel W., Wang, Yuan‐Fang, Aoki, Manabu, Takamatsu, Yuki, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (06.11.2019)
Published in ChemMedChem (06.11.2019)
Get full text
Journal Article
4′‐modified nucleoside analogs: Potent inhibitors active against entecavir‐resistant hepatitis B virus
Takamatsu, Yuki, Tanaka, Yasuhito, Kohgo, Satoru, Murakami, Shuko, Singh, Kamalendra, Das, Debananda, Venzon, David J., Amano, Masayuki, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Delino, Nicole S., Hayashi, Sanae, Takahashi, Satoru, Sukenaga, Yoshikazu, Haraguchi, Kazuhiro, Sarafianos, Stefan G., Maeda, Kenji, Mitsuya, Hiroaki
Published in Hepatology (Baltimore, Md.) (01.10.2015)
Published in Hepatology (Baltimore, Md.) (01.10.2015)
Get full text
Journal Article
GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants
Delino, Nicole S, Aoki, Manabu, Hayashi, Hironori, Hattori, Shin-Ichiro, Chang, Simon B, Takamatsu, Yuki, Martyr, Cuthbert D, Das, Debananda, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Get full text
Journal Article
Trimodal therapy with high-dose-rate brachytherapy and hypofractionated external beam radiation combined with long-term androgen deprivation for unfavorable-risk prostate cancer
Mori, Keiichiro, Sasaki, Hiroshi, Tsutsumi, Yuki, Sato, Shun, Takiguchi, Yuki, Saito, Shun, Nishi, Eriko, Ishii, Gen, Yamamoto, Toshihiro, Koike, Yusuke, Miki, Jun, Shimomura, Tatsuya, Kimura, Takahiro, Miki, Kenta, Shariat, Shahrokh F., Takahashi, Hiroyuki, Aoki, Manabu, Egawa, Shin
Published in Strahlentherapie und Onkologie (01.11.2021)
Published in Strahlentherapie und Onkologie (01.11.2021)
Get full text
Journal Article
Predictive factors for disease progression after salvage radiation therapy in biochemical recurrent patients treated by radical prostatectomy
Aikawa, Koichi, Kimura, Shoji, Urabe, Fumihiko, Iwatani, Kosuke, Tashiro, Kojiro, Ochi, Atsuhiko, Abe, Hirokazu, Aoki, Manabu, Kimura, Takahiro
Published in Prostate international (01.09.2023)
Published in Prostate international (01.09.2023)
Get full text
Journal Article
The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy
Tsutsumi, Yuki, Omura, Kazuhiro, Kijima, Yoshikazu, Kobayashi, Masao, Fukasawa, Nei, Takeda, Teppei, Ebihara, Teru, Aoki, Satoshi, Otori, Nobuyoshi, Kojima, Hiromi, Aoki, Manabu
Published in Cancer medicine (Malden, MA) (01.03.2024)
Published in Cancer medicine (Malden, MA) (01.03.2024)
Get full text
Journal Article
Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands
Ghosh, Arun K., Kovela, Satish, Sharma, Ashish, Shahabi, Dana, Ghosh, Ajay K., Hopkins, Denver R., Yadav, Monika, Johnson, Megan E., Agniswamy, Johnson, Wang, Yuan‐Fang, Hattori, Shin‐Ichiro, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (04.05.2022)
Published in ChemMedChem (04.05.2022)
Get full text
Journal Article
National survey of radiation oncologists’ practice patterns regarding hormone-naïve prostate cancer with bone metastases
Nakamura, Katsumasa, Ishikawa, Hitoshi, Akimoto, Tetsuo, Aoki, Manabu, Kariya, Shinji, Kawamura, Hidemasa, Kumano, Tomoyasu, Kozuka, Takuyo, Konishi, Kenta, Sakaguchi, Masakuni, Takayama, Kenji
Published in Japanese journal of clinical oncology (01.10.2020)
Published in Japanese journal of clinical oncology (01.10.2020)
Get full text
Journal Article