Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands
Ghosh, Arun K., Sean Fyvie, W., Brindisi, Margherita, Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex
Ghosh, Arun K., Brindisi, Margherita, Nyalapatla, Prasanth R., Takayama, Jun, Ella-Menye, Jean-Rene, Yashchuk, Sofiya, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry (01.10.2017)
Published in Bioorganic & medicinal chemistry (01.10.2017)
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The identification of ᴅ-tryptophan as a bioactive substance for postembryonic ovarian development in the planarian Dugesia ryukyuensis
Kobayashi, Kazuya, Maezawa, Takanobu, Tanaka, Hiroyuki, Onuki, Hiroyuki, Horiguchi, Yurie, Hirota, Hiroshi, Ishida, Tetsuo, Horiike, Kihachiro, Agata, Yasutoshi, Aoki, Manabu, Hoshi, Motonori, Matsumoto, Midori
Published in Scientific reports (24.03.2017)
Published in Scientific reports (24.03.2017)
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Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV‑1 Protease Inhibitors: Design, Synthesis, Protein X‑ray Structural Studies, and Biological Evaluation
Ghosh, Arun K, Osswald, Heather L, Glauninger, Kristof, Agniswamy, Johnson, Wang, Yuan-Fang, Hayashi, Hironori, Aoki, Manabu, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Journal Article
Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands
Ghosh, Arun K., Takayama, Jun, Kassekert, Luke A., Ella-Menye, Jean-Rene, Yashchuk, Sofiya, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir
Aoki, Manabu, Hayashi, Hironori, Yedidi, Ravikiran S, Martyr, Cuthbert D, Takamatsu, Yuki, Aoki-Ogata, Hiromi, Nakamura, Teruya, Nakata, Hirotomo, Das, Debananda, Yamagata, Yuriko, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Journal of virology (01.03.2016)
Published in Journal of virology (01.03.2016)
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Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS)
Saito, Shiro, Ito, Kazuto, Yorozu, Atsunori, Aoki, Manabu, Koga, Hirofumi, Satoh, Takefumi, Ohashi, Toshio, Shigematsu, Naoyuki, Maruo, Shinichiro, Kikuchi, Takashi, Kojima, Shinsuke, Dokiya, Takushi, Fukushima, Masanori, Yamanaka, Hidetoshi
Published in International journal of clinical oncology (01.04.2015)
Published in International journal of clinical oncology (01.04.2015)
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Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1
AOKI, Manabu, DANISH, Matthew L, AOKI-OGATA, Hiromi, AMANO, Masayuki, IDE, Kazuhiko, DAS, Debananda, KOH, Yasuhiro, MITSUYA, Hiroaki
Published in Journal of Virology (01.12.2012)
Published in Journal of Virology (01.12.2012)
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Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1
KOH, Yasuhiro, AOKI, Manabu, DANISH, Matthew L, AOKI-OGATA, Hiromi, AMANO, Masayuki, DAS, Debananda, SHAFER, Robert W, GHOSH, Arun K, MITSUYA, Hiroaki
Published in Journal of Virology (01.10.2011)
Published in Journal of Virology (01.10.2011)
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A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance
Aoki, Manabu, Chang, Simon B., Das, Debananda, Martyr, Cuthbert, Delino, Nicole S., Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Published in Global Health & Medicine (31.10.2019)
Published in Global Health & Medicine (31.10.2019)
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GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro
AMANO, Masayuki, TOJO, Yasushi, SALCEDO-GOMEZ, Pedro Miguel, CAMPBELL, Joseph Richard, DAS, Debananda, AOKI, Manabu, XU, Chun-Xiao, RAO, Kalapala Venkateswara, GHOSH, Arun K, MITSUYA, Hiroaki
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
Published in Antimicrobial Agents and Chemotherapy (01.05.2013)
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P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety
YEDIDI, Ravikiran S, MAEDA, Kenji, DAS, Debananda, WINGFIELD, Paul T, GHOSH, Arun K, MITSUYA, Hiroaki, SEAN FYVIE, W, STEFFEY, Melinda, DAVIS, David A, PALMER, Ira, AOKI, Manabu, KAUFMAN, Joshua D, STAHL, Stephen J, GARIMELLA, Harisha
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
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Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice
Higashi-Kuwata, Nobuyo, Ogata-Aoki, Hiromi, Hattori, Shin-ichiro, Hayashi, Hironori, Danish, Matthew, Aoki, Manabu, Shiotsu, Chiemi, Kawamura, Tatsuyoshi, Ihn, Hironobu, Kobayashi, Hisataka, Okada, Seiji, Mitsuya, Hiroaki
Published in Antiviral research (01.08.2017)
Published in Antiviral research (01.08.2017)
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Design of gem-Difluoro-bis-Tetrahydrofuran as P2 Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation
Ghosh, Arun K., Yashchuk, Sofiya, Mizuno, Akira, Chakraborty, Nilanjana, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Gomez, Pedro Miguel Salcedo, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (01.01.2015)
Published in ChemMedChem (01.01.2015)
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Mid-term outcome of permanent prostate iodine-125 brachytherapy in Japanese patients
Kimura, Takahiro, Kido, Masahito, Miki, Kenta, Yamamoto, Toshihiro, Sasaki, Hiroshi, Kuruma, Hidetoshi, Hayashi, Norihiro, Takahashi, Hiroyuki, Aoki, Manabu, Egawa, Shin
Published in International journal of urology (01.05.2014)
Published in International journal of urology (01.05.2014)
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Results of central pathology review of prostatic biopsies in a contemporary series from a phase III, multicenter, randomized controlled trial (SHIP0804)
Sasaki, Hiroshi, Kido, Masahito, Miki, Kenta, Aoki, Manabu, Takahashi, Hiroyuki, Dokiya, Takushi, Yamanaka, Hidetoshi, Fukushima, Masanori, Egawa, Shin
Published in Pathology international (01.04.2015)
Published in Pathology international (01.04.2015)
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Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants
IDE, Kazuhiko, AOKI, Manabu, AMANO, Masayuki, KOH, Yasuhiro, YEDIDI, Ravikiran S, DAS, Debananda, LESCHENKO, Sofiya, CHAPSAL, Bruno, GHOSH, Arun K, MITSUYA, Hiroaki
Published in Antimicrobial Agents and Chemotherapy (01.04.2011)
Published in Antimicrobial Agents and Chemotherapy (01.04.2011)
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Multi-institutional retrospective analysis of learning curves on dosimetry and operation time before and after introduction of intraoperatively built custom-linked seeds in prostate brachytherapy
Ishiyama, Hiromichi, Satoh, Takefumi, Yorozu, Atsunori, Saito, Shiro, Kataoka, Masaaki, Hashine, Katsuyoshi, Nakamura, Ryuji, Tanji, Susumu, Masui, Koji, Okihara, Koji, Ohashi, Toshio, Momma, Tetsuo, Aoki, Manabu, Miki, Kenta, Kato, Masako, Morita, Masashi, Katayama, Norihisa, Nasu, Yasutomo, Kawanaka, Takashi, Fukumori, Tomoharu, Ito, Fumitaka, Shiroki, Ryoichi, Baba, Yuji, Inadome, Akito, Yoshioka, Yasuo, Takayama, Hitoshi, Hayakawa, Kazushige
Published in Journal of radiation research (01.01.2016)
Published in Journal of radiation research (01.01.2016)
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