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Yeoh, Sharon, O'Donnell, Rebecca A., Koussis, Konstantinos, Dluzewski, Anton R., Ansell, Keith H., Osborne, Simon A., Hackett, Fiona, Withers-Martinez, Chrislaine, Mitchell, Graham H., Bannister, Lawrence H., Bryans, Justin S., Kettleborough, Catherine A., Blackman, Michael J.
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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
Green, Judith L, Moon, Robert W, Whalley, David, Bowyer, Paul W, Wallace, Claire, Rochani, Ankit, Nageshan, Rishi K, Howell, Steven A, Grainger, Munira, Jones, Hayley M, Ansell, Keith H, Chapman, Timothy M, Taylor, Debra L, Osborne, Simon A, Baker, David A, Tatu, Utpal, Holder, Anthony A
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Published in Antimicrobial agents and chemotherapy (01.03.2016)
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Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG)
Tsagris, Denise J., Birchall, Kristian, Bouloc, Nathalie, Large, Jonathan M., Merritt, Andy, Smiljanic-Hurley, Ela, Wheldon, Mary, Ansell, Keith H., Kettleborough, Catherine, Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
Published in Bioorganic & medicinal chemistry letters (15.10.2018)
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Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty
Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
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Discovery of Plasmodium vivax N-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode
Goncalves, Victor, Brannigan, James A, Whalley, David, Ansell, Keith H, Saxty, Barbara, Holder, Anthony A, Wilkinson, Anthony J, Tate, Edward W, Leatherbarrow, Robin J
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)
Chapman, Timothy M, Osborne, Simon A, Wallace, Claire, Birchall, Kristian, Bouloc, Nathalie, Jones, Hayley M, Ansell, Keith H, Taylor, Debra L, Clough, Barbara, Green, Judith L, Holder, Anthony A
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines
Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
Chapman, Timothy M., Osborne, Simon A., Bouloc, Nathalie, Large, Jonathan M., Wallace, Claire, Birchall, Kristian, Ansell, Keith H., Jones, Hayley M., Taylor, Debra, Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
Ansell, Keith H, Jones, Hayley M, Whalley, David, Hearn, Alisdair, Taylor, Debra L, Patin, Emmanuel C, Chapman, Timothy M, Osborne, Simon A, Wallace, Claire, Birchall, Kristian, Large, Jonathan, Bouloc, Nathalie, Smiljanic-Hurley, Ela, Clough, Barbara, Moon, Robert W, Green, Judith L, Holder, Anthony A
Published in Antimicrobial agents and chemotherapy (01.10.2014)
Published in Antimicrobial agents and chemotherapy (01.10.2014)
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Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues
Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
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Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7
Bouloc, Nathalie, Large, Jonathan M., Smiljanic, Ela, Whalley, David, Ansell, Keith H., Edlin, Christopher D., Bryans, Justin S.
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
Baker, David A, Stewart, Lindsay B, Large, Jonathan M, Bowyer, Paul W, Ansell, Keith H, Jiménez-Díaz, María B, El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J, Bouloc, Nathalie S, Coombs, Peter J, Whalley, David, Harding, Denise J, Smiljanic-Hurley, Ela, Wheldon, Mary C, Walker, Eloise M, Dessens, Johannes T, Lafuente, María José, Sanz, Laura M, Gamo, Francisco-Javier, Ferrer, Santiago B, Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T, Croft, Simon L, Gutteridge, Winston E, Kettleborough, Catherine A, Osborne, Simon A
Published in Nature communications (05.09.2017)
Published in Nature communications (05.09.2017)
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Corrigendum to “Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues” [Bioorg. Med. Chem. Lett. 23 (2013) 6019–6024]
Large, Jonathan M., Osborne, Simon A., Smiljanic-Hurley, Ela, Ansell, Keith H., Jones, Hayley M., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
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Isolation of tumor cell-specific single-chain Fv from immunized mice using phage-antibody libraries and the re-construction of whole antibodies from these antibody fragments
Kettleborough, C A, Ansell, K H, Allen, R W, Rosell-Vives, E, Güssow, D H, Bendig, M M
Published in European journal of immunology (01.04.1994)
Published in European journal of immunology (01.04.1994)
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A Protein from the Salivary Glands of the Giant Amazon Leech with High Sequence Homology to a Nicotinic Acetylcholine Receptor Subunit
Salgueiro, Sancha, Potts, Susan, Mcllgorm, E. Ann, Ansell, Keith H., Hemberger, Jürgen, Güssow, Detlef
Published in Zeitschrift für Naturforschung C. A journal of biosciences (01.11.1999)
Published in Zeitschrift für Naturforschung C. A journal of biosciences (01.11.1999)
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ANTI-EGFR SINGLE-CHAIN FVS AND ANTI-EGFR ANTIBODIES
PIULATS, JAIME, ADAN, JAIME, KETTLEBOROUGH, CATHERINE A, MITJANS, FRANCESC, ROSELL, ELISABET, GUSSOW, DETLEF, BENDIG, MARY M, BLASCO, FRANCESC, ANSELL, KEITH H
Year of Publication 08.12.2009
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Year of Publication 08.12.2009
Patent
FV MONOCATENARIOS ANTI-EGFR Y ANTICUERPOS ANTI-EGFR
ADAN, JAIME, KETTLEBOROUGH, A. CATHRINE, MITJANS, FRANCESC, GUSSOW, DETLEF, BENDIG, MARY M, ANSELL, KEITH H
Year of Publication 16.09.2003
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Year of Publication 16.09.2003
Patent