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Antibody–Drug Conjugates with Pyrrole‐Based KSP Inhibitors as the Payload Class

Antibody–Drug Conjugates with Pyrrole‐Based KSP Inhibitors as the Payload Class

by Lerchen, Hans‐Georg, Wittrock, Sven, Stelte‐Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne‐Sophie, Johannes, Sarah, Cancho‐Grande, Yolanda, Mahlert, Christoph, Greven, Simone, Terjung, Carsten
Published in Angewandte Chemie International Edition (12.11.2018)

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Journal Article

Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation

Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation

by Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone
Published in Chemistry : a European journal (21.06.2019)

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Journal Article

Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

by Rebstock, Anne-Sophie, Wiedmann, Mareike, Stelte-Ludwig, Beatrix, Wong, Harvey, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed, Lerchen, Hans-Georg
Published in Frontiers in pharmacology (01.03.2024)

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Journal Article

Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation

Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation

by Lerchen, Hans‐Georg, Stelte‐Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne‐Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone
Published in Chemistry : a European journal (21.06.2019)

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Journal Article

Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA

Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA

by Gooding, Matt, Tudzarova, Slavica, Worthington, Roberta J., Kingsbury, Sarah R., Rebstock, Anne-Sophie, Dube, Henry, Simone, Michela I., Visintin, Cristina, Lagos, Dimitris, Quesada, Juan-Manuel Funes, Laman, Heike, Boshoff, Chris, Williams, Gareth H., Stoeber, Kai, Selwood, David L.
Published in Chemical biology & drug design (01.01.2012)

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Journal Article

Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads

Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads

by Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah
Published in Bioconjugate chemistry (19.08.2020)

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Journal Article

Endothelial C-type natriuretic peptide maintains vascular homeostasis

Endothelial C-type natriuretic peptide maintains vascular homeostasis

by Moyes, Amie J, Khambata, Rayomand S, Villar, Inmaculada, Bubb, Kristen J, Baliga, Reshma S, Lumsden, Natalie G, Xiao, Fang, Gane, Paul J, Rebstock, Anne-Sophie, Worthington, Roberta J, Simone, Michela I, Mota, Filipa, Rivilla, Fernando, Vallejo, Susana, Peiró, Concepción, Sánchez Ferrer, Carlos F, Djordjevic, Snezana, Caulfield, Mark J, MacAllister, Raymond J, Selwood, David L, Ahluwalia, Amrita, Hobbs, Adrian J
Published in The Journal of clinical investigation (01.09.2014)

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Journal Article

Modular Assembly Using Sequential Palladium Coupling Gives Easy Access to the SMoC Class of Cellular Transporters

Modular Assembly Using Sequential Palladium Coupling Gives Easy Access to the SMoC Class of Cellular Transporters

by Rebstock, Anne-Sophie, Visintin, Cristina, Leo, Elisabetta, Garcia Posada, Cristina, Kingsbury, Sarah R, Williams, Gareth H, Stoeber, Kai, Selwood, David L
Published in Chembiochem : a European journal of chemical biology (21.07.2008)

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Journal Article

Innentitelbild: Antikörper‐Wirkstoff‐Konjugate mit Pyrrol‐basierten KSP‐Inhibitoren als Payload‐Klasse (Angew. Chem. 46/2018)

Innentitelbild: Antikörper‐Wirkstoff‐Konjugate mit Pyrrol‐basierten KSP‐Inhibitoren als Payload‐Klasse (Angew. Chem. 46/2018)

by Lerchen, Hans‐Georg, Wittrock, Sven, Stelte‐Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne‐Sophie, Johannes, Sarah, Cancho‐Grande, Yolanda, Mahlert, Christoph, Greven, Simone, Terjung, Carsten
Published in Angewandte Chemie (12.11.2018)

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Synthesis and metallation of 2-(pyridyl)benzoic acids and ethyl 2-(pyridyl)benzoates: a new route to azafluorenones

Synthesis and metallation of 2-(pyridyl)benzoic acids and ethyl 2-(pyridyl)benzoates: a new route to azafluorenones

by Rebstock, Anne-Sophie, Mongin, Florence, Trécourt, François, Quéguiner, Guy
Published in Tetrahedron (30.06.2003)

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Journal Article

Metallation of pyridines and quinolines in the presence of a remote carboxylate group. New syntheses of heterocyclic quinones

Metallation of pyridines and quinolines in the presence of a remote carboxylate group. New syntheses of heterocyclic quinones

by Rebstock, AS, Mongin, F, Trecourt, F, Queguiner, G
Published in Organic & biomolecular chemistry (07.02.2004)

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Journal Article

Regioselectivities in deprotonation of 2-(4-chloro-2-pyridyl)benzoic acid and corresponding ester and amide

Regioselectivities in deprotonation of 2-(4-chloro-2-pyridyl)benzoic acid and corresponding ester and amide

by Rebstock, Anne-Sophie, Mongin, Florence, Trécourt, François, Quéguiner, Guy
Published in Tetrahedron (01.03.2004)

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Journal Article

SPECIFIC ANTIBODY-DRUG CONJUGATES (ADCS) COMPRISING KSP INHIBITORS AND ANTI-CD123 ANTIBODIES

SPECIFIC ANTIBODY-DRUG CONJUGATES (ADCS) COMPRISING KSP INHIBITORS AND ANTI-CD123 ANTIBODIES

by BEATRIX STELTE-LUDWIG, ANNE-SOPHIE REBSTOCK, SVEN WITTROCK, STEPHAN MAERSCH, YOLANDA CANCHO GRANDE, DENNIS KIRCHHOFF, CHRISTOPH MAHLERT, HANS-GEORG LERCHEN, SIMONE GREVEN
Year of Publication 05.08.2021

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Patent

Synthesis and Deprotonation of 2-(Halophenyl)pyridines and 1-(Halophenyl)isoquinolines

Synthesis and Deprotonation of 2-(Halophenyl)pyridines and 1-(Halophenyl)isoquinolines

by Mongin, Florence, Rebstock, Anne-Sophie, Trécourt, François, Quéguiner, Guy, Marsais, Francis
Published in Journal of organic chemistry (01.10.2004)

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Journal Article

Directed lithiation of unprotected pyridinecarboxylic acids: syntheses of halo derivatives

Directed lithiation of unprotected pyridinecarboxylic acids: syntheses of halo derivatives

by Lazaar, Jalal, Rebstock, Anne-Sophie, Mongin, Florence, Godard, Alain, Trécourt, François, Marsais, Francis, Quéguiner, Guy
Published in Tetrahedron (12.08.2002)

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Journal Article

Directed lithiation of unprotected quinolinecarboxylic acids

Directed lithiation of unprotected quinolinecarboxylic acids

by Rebstock, AS, Mongin, F, Trecourt, F, Queguiner, G
Published in Tetrahedron letters (28.01.2002)

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Journal Article

Synthesis and deprotonation of 2-(pyridyl)phenols and 2-(pyridyl)anilines

Synthesis and deprotonation of 2-(pyridyl)phenols and 2-(pyridyl)anilines

by Rebstock, AS, Mongin, F, Trecourt, F, Queguiner, G
Published in Organic & biomolecular chemistry (07.09.2003)

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Journal Article

Comparison of the CXCR5-Antibody Drug Conjugate (ADC; VIP924) to a CD19-ADC and a CD79b-ADC in a Humanized Rec-1 Mantle Cell Lymphoma (MCL) Mouse Model

Comparison of the CXCR5-Antibody Drug Conjugate (ADC; VIP924) to a CD19-ADC and a CD79b-ADC in a Humanized Rec-1 Mantle Cell Lymphoma (MCL) Mouse Model

by Schomber, Tibor, Stelte-Ludwig, Beatrix, Rebstock, Anne-Sophie, v Ahsen, Oliver, Johnson, Amy J, Izumi, Raquel, Hamdy, Ahmed
Published in Blood (02.11.2023)

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Journal Article

Selectivity and Safety of VIP943: A Novel CD123-Targeting Antibody-Drug Conjugate (ADC) Using a Proprietary Linker and Payload Class

Selectivity and Safety of VIP943: A Novel CD123-Targeting Antibody-Drug Conjugate (ADC) Using a Proprietary Linker and Payload Class

by Stelte-Ludwig, Beatrix, Schomber, Tibor, Izumi, Raquel, Wong, Harvey, Frigault, Melanie M, Rebstock, Anne-Sophie, Ludwig, Sebastian, Mithal, Arushi, Johnson, Amy J, Hamdy, Ahmed
Published in Blood (02.11.2023)

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Journal Article

Abstract 228: KSPi-ADCs: ADCs with novel kinesin spindle protein inhibitor payloads and a tailor-made linker chemistry

Abstract 228: KSPi-ADCs: ADCs with novel kinesin spindle protein inhibitor payloads and a tailor-made linker chemistry

by Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Marx, Leo, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Weinmann, Hilmar
Published in Cancer research (Chicago, Ill.) (01.07.2019)

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Journal Article

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